The Prevalence of Dyslipidemia in Patients with Spinal Cord Lesion in Thailand

Vichiansiri, Ratana; Saengsuwan, Jiamjit; Manimmanakorn, Nuttaset; Sirasaporn, Patpiya; Arayawichanon, Preeda; Kharmwan, Samerduen; Poosiripinyo, E.

doi:10.1155/2012/847462

Cited by 15 publications

(23 citation statements)

References 31 publications

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“…High TG levels, described as >150 mg/dL, were present in 34.6 percent of the patients with SCI. Consistent with our findings, Vichiansiri et al reported high TG levels in 28.9 percent of patients with chronic SCI [37]. Groah et al, in a cross-sectional study of 121 subjects with chronic SCI, showed that 305 had high levels of TG [4].…”

Section: Sabour Et Al Cardiometabolic Risk Factors In People With Scisupporting

confidence: 92%

“…The remarkable percentage of patients with low HDL-C in these patients may be explained by the lower physical activity levels in this group. Other causes of lower HDL-C, such as a high-fat diet [35][36][37], shown in our previous related study [13], may also contribute to low HDL-C in these patients.…”

Section: Sabour Et Al Cardiometabolic Risk Factors In People With Scimentioning

confidence: 66%

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Cardiometabolic risk factors in Iranians with spinal cord injury: Analysis by injury-related variables

Sabour

Javidan²,

Ranjbarnovin³

et al. 2013

JRRD

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Abstract-Persons with spinal cord injury (SCI) have a high prevalence of abnormalities in carbohydrate and lipid metabolism. These abnormalities cause adverse coronary heart disease (CHD) in patients with SCI. In this study, we performed a detailed analysis of the level-specific cardiometabolic risk factors in individuals with SCI and analyzed the association of injury level on these risk factors. This was a cross-sectional study of 162 patients with SCI, assessing the prevalence of diabetes mellitus, dyslipidemia, hypertension, obesity, and smoking. Fasting blood sugar (>100) was diagnosed in 27 patients (16.7%). Of the total patients, 36 (22.2%) had a total cholesterol (TC) level of >200. A triglyceride level of >150 was present in 56 patients (34.6%). Hypertension was present in 2.5% of the entire patient group. Body mass index (BMI), TC, and low-density lipoprotein cholesterol (LDL-C) were significantly higher in the paraplegia group than the tetraplegia group (24.44 +/-4.23 vs 22.65 +/-4.27, p = 0. 01; 185.71 +/-40.69 vs 163.28 +/-37.92, p < 0.001; and 102.51 +/-28.20 vs 89.15 +/-22.35, p = 0.01, respectively). Patients with paraplegia may have increased hypertension, higher BMI, and increasing levels of serum LDL-C and TC than those with tetraplegia. Conventional risk factors for CHD should be identified and treated in individuals with SCI.

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Section: Sabour Et Al Cardiometabolic Risk Factors In People With Scisupporting

confidence: 92%

Section: Sabour Et Al Cardiometabolic Risk Factors In People With Scimentioning

confidence: 66%

Cardiometabolic risk factors in Iranians with spinal cord injury: Analysis by injury-related variables

Sabour

Javidan²,

Ranjbarnovin³

et al. 2013

JRRD

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“…Attenuated NVC, even after midodrine, could be due to a variety of factors outside of low BP, including reduced nitric oxide availability, 38 glucose intolerance, 39 and dyslipidemia. 40 This study clearly showed that NVC of the MCA is preserved to AB levels in those with SCI. These findings appear to be in opposition to that reported by Jegede et al (2010) 9 ; however, differences may be explained by a combination of (a) a dissimilar cognitive task (i.e., verbal fluency versus Stroop test), (b) a more stringent procedure (i.e., seven versus three cycles averaged), or (c) shorter activation period averaged (30 versus 45 seconds that we used in our study).…”

Section: Discussionmentioning

confidence: 53%

Regional Neurovascular Coupling and Cognitive Performance in Those with Low Blood Pressure Secondary to High-Level Spinal Cord Injury: Improved by Alpha-1 Agonist Midodrine Hydrochloride

Phillips

Warburton

Ainslie

et al. 2014

J Cereb Blood Flow Metab

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Individuals with high-level spinal cord injury (SCI) experience low blood pressure (BP) and cognitive impairments. Such dysfunction may be mediated in part by impaired neurovascular coupling (NVC) (i.e., cerebral blood flow responses to neurologic demand). Ten individuals with SCI 4T6 spinal segment, and 10 age-and sex-matched controls were assessed for beat-by-beat BP, as well as middle and posterior cerebral artery blood flow velocity (MCAv, PCAv) in response to a NVC test. Tests were repeated in SCI after 10 mg midodrine (alpha 1 -agonist). Verbal fluency was measured before and after midodrine in SCI, and in the control group as an index of cognitive function. At rest, mean BP was lower in SCI (70 ± 10 versus 92 ± 14 mm Hg; Po0.05); however, PCAv conductance was higher (0.56 ± 0.13 versus 0.39 ± 0.15 cm/second/mm Hg; Po0.05). Controls exhibited a 20% increase in PCAv during cognition; however, the response in SCI was completely absent (Po0.01). When BP was increased with midodrine, NVC was improved 70% in SCI, which was reflected by a 13% improved cognitive function (Po0.05). Improvements in BP were related to improved cognitive function in those with SCI (r 2 ¼ 0.52; Po0.05). Impaired NVC, secondary to low BP, may partially mediate reduced cognitive function in individuals with high-level SCI. INTRODUCTIONSpinal cord injury (SCI) is a devastating condition often resulting in disturbed motor, sensory, and autonomic function. As a result of disrupted descending autonomic spinal pathways after SCI, sympathetic vasomotor tone is impaired, often resulting in arterial hypotension. 1 Those with injury at or above T 6 spinal segment, because of a myriad of potential mechanisms (including decentralization of sympathetically mediated vasomotor tone in the splanchnic region and legs) have more profound autonomic disturbances including resting hypotension and orthostatic hypotension as compared with those with lower level SCI. 2 An abundance of evidence, from both animal and human studies, demonstrated that there is an association between low blood pressure (BP) and a variety of cognitive impairments. 3,4 There is well-established evidence that individuals with SCI have a high rate of traumatic brain injury that can result in a significant number of cognitive dysfunctions. 5 However, the high prevalence of cognitive dysfunction (i.e., between 10% and 60%) in SCI 6,7 is likely to be at least partially due to widespread hypotension. 8 This notion is further highlighted by a significant positive relationship between systolic BP (SBP) and cognitive function in the SCI population. 9

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“…Bel-Serrat et al 4 investigated healthy adolescent whereas we studied people with SCI who are known to be susceptible to metabolic syndrome 20,21 and dyslipidemia. [22][23][24] To our knowledge, this is the first study illustrating the association between dietary # TG and cholesterol were significantly higher among men whereas women had higher levels of HDL-C. TG was higher among people with incomplete spinal cord injury.ˆS ystolic and diastolic blood pressures were higher among people with complete spinal cord injury. ¥ TG and blood pressure were significantly higher among people with quadriplegia whereas higher levels of HDL were detected among paraplegics.…”

Section: Discussionmentioning

confidence: 70%

“…3 Up to now, there is no study illustrating association between amino acids dietary intake and lipid profile among individuals with spinal cord injury (SCI). Furthermore, adverse effects of SCI on serum lipoprotein profiles have been demonstrated, [5][6][7] which shows that people with SCI have potential susceptibility toward hyperlipidemia and dyslipidemia. Thus, it is clinically essential to identify the dietary components which may contribute to dyslipidemia among individuals with SCI.…”

Section: Introductionmentioning

confidence: 99%

Is the pattern of dietary amino acids intake associated with serum lipid profile and blood pressure among individuals with spinal cord injury?

Javidan

Sabour

Nazari

et al. 2015

The Journal of Spinal Cord Medicine

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Objective: The probable effect of dietary amino acids intake pattern on serum lipid profile and blood pressure (BP) have not yet been described among individuals with spinal cord injury (SCI). Design: Cross-sectional. Setting: Tertiary rehabilitation center. Participants: People with SCI referred to Brain and Spinal Cord Injury Research Center between 2011 and 2014. Outcome measures: Dietary intakes were assessed by recording consumed foods by 24-hour dietary recall interviews using Nutritionist IV 3.5.3 modified for Iranian foods. Partial correlation test with adjustment for age, weight, body mass index, total energy intake, total fat, cholesterol and carbohydrate intake, and injury-related variables was used. Results: Dietary intake of lysine was positively related to levels of fasting plasma glucose (FPG), triglyceride (TG), systolic blood pressure (SBP) and diastolic blood pressure (DBP) (P < 0.0001, 0.046, 0.002 and 0.009, respectively). There was a positive significant relationship between the intake of cysteine and levels of TG and SBP as well (P : 0.027 and 0.048, respectively). Higher intakes of threonine and leucine had a negative relationship with TG level (P : 0.001 and 0.026, respectively). Furthermore, tyrosine, threonine and leucine were inversely correlated to blood pressure. Total cholesterol level was only related to intake of threonine and leucine (P : 0.004 and 0.012, respectively). FPG was positively associated with intake of all amino acids except for cysteine, glutamic acid, threonine, leucine and histidine. Conclusion: In the present study, the pattern of relationships between dietary intake of amino acids and serum lipid profile and BP has been described among people with SCI.

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The Prevalence of Dyslipidemia in Patients with Spinal Cord Lesion in Thailand

Cited by 15 publications

References 31 publications

Cardiometabolic risk factors in Iranians with spinal cord injury: Analysis by injury-related variables

Cardiometabolic risk factors in Iranians with spinal cord injury: Analysis by injury-related variables

Regional Neurovascular Coupling and Cognitive Performance in Those with Low Blood Pressure Secondary to High-Level Spinal Cord Injury: Improved by Alpha-1 Agonist Midodrine Hydrochloride

Is the pattern of dietary amino acids intake associated with serum lipid profile and blood pressure among individuals with spinal cord injury?

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