The prevalence of fimA genotypes of Porphyromonas gingivalis in patients with chronic periodontitis: A meta-analysis

Abstract

FimA is an important virulence factor of Porphyromonas gingivalis ( P . gingivalis) . According to its DNA sequence, the fimA genotype of P . gingivalis can be divided into six categories (I, Ib, Ⅱ, III, IV, V). The fimA gene may be a key factor in the diversity of virulence found in P . gingivalis . Moreover, the role fimA plays in the pathogenesis of P . gingivalis is closely associated with periodontitis, making it an important factor of study for disease prevention and treatment. In this study, the prevalence of fimA genotypes of P . gingivalis in patients with periodontal diseases was evaluated by meta-analysis. The Embase and PubMed databases were searched for articles from 1999 to 2019 using the following search terms: Porphyromonas gingivalis or P . gingivalis; periodontitis or chronic periodontal disease; fimA or fimA genotype. The reference lists of relevant published articles were searched manually. A total of 17 studies were included in this report. A statistical software package (Stata, version 11.0/mp, StataCorp) was utilized to calculate and analyze the P . gingivalis fimA genotypes for each combined incidence estimate. The pooled rates of fimA Ⅰ, fimA Ib, fimA Ⅱ, fimA Ⅲ, fimA Ⅳ and fimA Ⅴ genotypes of P . gingivalis were 8.4% (95% CI: 5.7–11.1), 11.7% (95% CI: 7.4–16), 42.9% (95% CI: 34.2–51.7), 6.5% (95% CI: 5.1–7.9), 17.8% (95% CI: 9.0–26.5), and 3.2% (95% CI: 1.6–4.9), respectively. This study showed that the fimA Ⅱ and fimA Ⅳ genotypes of P . gingivalis are highly present in patients with periodontal disease. Therefore, these two genotypes may be related to the pathogenesis and progress of periodontal disease, one of the main risk factors of periodontitis.

Porphyromonas gingivalis FimA and Mfa1 fimbriae: Current insights on localization, function, biogenesis, and genotype

“…Heterogeneous virulence of P. gingivalis has been attributed to a high degree of genetic clonal diversity. Several international studies reported that fimA genotypes II and IV were detected predominantly in patients with severe periodontitis whereas fimA genotype I was prevalent mainly in healthy patients and mild periodontitis cases [ [126] , [127] , [128] , [129] ]. However, fimA genotype I has also been observed at high frequency in patients with severe periodontitis [ 130 ].…”

The RagA and RagB proteins of Porphyromonas gingivalis

“…The same is true for ragB . Four rag variant types have been described or detected in oral samples (Dashper et al., 2017; Hall et al., 2005; Liu et al., 2013; Su et al., 2010; Wang et al., 2009). In a comparison of the genomes of 23 P. gingivalis strains Dashper et al.…”

DNA-aptamer-nanographene oxide as a targeted bio-theragnostic system in antimicrobial photodynamic therapy against Porphyromonas gingivalis

“…P. gingivalis produces fimbrillin ( fimA ) and arginine protease ( rgpA ) genes that are involved in several functions including adherence to host cells, formation of microbial biofilm, inhibition of host defenses, and damage to host cells 8 , 9 . Additionally, P. gingivalis has a sophisticated regulation system which is known as the oxidative stress response gene ( oxyR ) that protects the bacteria against harsh environments 10 .…”