The preventive effect of sustained physical activity on incident nonalcoholic fatty liver disease

Kwak, Min‐Sun; Kim, Dong‐Hee; Chung, Gyung Ho; Kim, Won; Kim, Sang Woo

doi:10.1111/liv.13332

Cited by 33 publications

(37 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, smoking and alcohol consumption along with high BMI were associated with NAFLD, which is consistent with the results of previous studies on the relationship between smoking, [30,31] alcohol [4], [22] and BMI [1], [6], [22], [32] and NAFLD. The onset and progression of NAFLD, apart from the quantity and quality of food and exercise, are also associated with other aspects of lifestyle, including alcohol consumption less than 20 g/day [22].…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

The Lifestyle Characteristics in Non-Alcoholic Fatty Liver Disease in the PERSIAN Guilan Cohort Study

Mansour-Ghanaei¹,

Mansour-Ghanaei²,

Naghipour³

et al. 2019

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease worldwide. Since the effect and safety of pharmacotherapy for NAFLD are unknown, the proper management of lifestyle is crucial. AIM: The present study was conducted to determine the status of food, Physical Activity (PA), and sleep in patients with and without NAFLD. METHODS: In this analytical- cross-sectional study, 630 clients with 36-60 years old who referred to the PERSIAN Guilan cohort study were included through simple non-random sampling. The developed questionnaire and lifestyle characteristics, including the status of nutrition, physical activity, and sleep, were completed for all samples. BMI was also calculated by determining weight and height, and fatty liver was confirmed based on abdominal ultrasound. RESULTS: The prevalence of NAFLD in this study was by 43.7% (275 / 630). Smoking, alcohol consumption, BMI, and weight loss over the past six months, regular exercise and exercise intensity, sedentary living, speed of eating, consuming fatty food, red meat, sweets beverages, and use of saturated fatty acid (SFA), and consuming fruits and vegetables were associated with presence of NAFLD (all p < 0.05). However, no significant relationship was observed between the parameters of sleep duration, the interval between dinner and night sleep, consuming breakfast and snack during the day and NAFLD (All p > 0.05). CONCLUSION: The onset and progression of NAFLD are associated with lifestyle. Therefore, dietary therapy solutions, physical activity, and sleep and rest situations should be paid attention for people with or at risk of NAFLD.

show abstract

Section: Discussionsupporting

confidence: 92%

“…On the other hand, the study by Imaizumi [28] did not report the relationship between skipping breakfast and NAFLD, which is in line with our study. Various studies have been reported a positive relationship between consuming carbohydrate as well as sweets and NAFLD [1], [30], [35].…”

Section: Discussionmentioning

confidence: 99%

The Lifestyle Characteristics in Non-Alcoholic Fatty Liver Disease in the PERSIAN Guilan Cohort Study

Mansour-Ghanaei¹,

Mansour-Ghanaei²,

Naghipour³

et al. 2019

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…The American College of Sports Medicine recommends at least 200 minutes per week of moderate‐intensity exercise (~1200 MET‐minutes/week, comparable to our DE group and significantly more than our LI group) to prevent weight regain . Physical activity level protects against development of NAFLD independent of insulin resistance and visceral adiposity, underscoring the importance of continued regular exercise to prevent accumulation of hepatic fat. Successful weight‐loss interventions in NAFLD studies involved individual counselling, goal setting and assessment every 3‐12 months, and staff contacts up to 20 times annually…”

Section: Discussionmentioning

confidence: 68%

“…40 The American College of Sports Medicine recommends at least 200 minutes per week of moderate-intensity exercise (~1200 MET-minutes/week, comparable to our DE group and significantly more than our LI group) to prevent weight regain. 18 Physical activity level protects against development of NAFLD independent of insulin resistance and visceral adiposity, 41 were found to be more responsive biomarkers compared to histology 42 and cCK-18 changes have been correlated with histological progression. 25 MRI elastography has been validated as a non-invasive measure of fibrosis 20 .…”

Section: Assessment For Eligibilitymentioning

confidence: 99%

Randomized trial comparing effects of weight loss by liraglutide with lifestyle modification in non‐alcoholic fatty liver disease

Khoo

Hsiang

Taneja

et al. 2019

Liver International

View full text Add to dashboard Cite

Background & Aims We compared the effects of weight loss induced with the glucagon‐like peptide‐1 agonist liraglutide, with that of lifestyle modification, followed by weight maintenance after discontinuing intervention, in obese adults with non‐alcoholic fatty liver disease (NAFLD). Methods Thirty obese (mean age 40.7 ± 9.1 years, BMI 33.2 ± 3.6 kg/m2, 90% male) adults with NAFLD defined as liver fat fraction (LFF) > 5% on magnetic resonance imaging without other causes of hepatic steatosis were randomized to a supervised programme of energy restriction plus moderate‐intensity exercise to induce ≥ 5% weight loss (DE group, n = 15), or liraglutide 3 mg daily (LI group, n = 15) for 26 weeks, followed by 26 weeks with only advice to prevent weight regain. Results Diet and exercise and LI groups had significant (P < 0.01) and similar reductions in weight (−3.5 ± 3.3 vs −3.0 ± 2.2 kg), LFF (−8.1 ± 13.2 vs −7.0 ± 7.1%), serum alanine aminotransferase (−39 ± 35 vs −26 ± 33 U/L) and caspase‐cleaved cytokeratin‐18 (cCK‐18) (−206 ± 252 vs −130 ± 158 U/L) at 26 weeks. At 52 weeks, the LI group significantly (P < 0.05) regained weight (1.8 ± 2.1 kg), LFF (4.0 ± 5.3%) and cCK‐18 (72 ± 126 U/L), whereas these were unchanged in the DE group. Conclusions Liraglutide was effective for decreasing weight, hepatic steatosis and hepatocellular apoptosis in obese adults with NAFLD, but benefits were not sustained after discontinuation, in contrast with lifestyle modification. Continuing the exercise learned in the structured programme contributed to the maintenance of liver fat reduction.

show abstract

“…129 A recent prospective cohort study from our group demonstrated a lower risk of incident NAFLD in 4 years of follow-up based on physical activity level at baseline. 130 Furthermore, sustained or increased physical activity had a preventive effect on incident NAFLD, independent of visceral adiposity and insulin resistance. 130 In summary, increased physical activity is an important component of lifestyle modification in patients with NAFLD and comorbid extrahepatic manifestations, irrespective of visceral obesity or insulin resistance.…”

Section: Physical Activitymentioning

confidence: 97%

Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease

Kim

2020

Gut and Liver

Self Cite

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and encompasses a spectrum of pathology from simple steatosis to inflammation and significant fibrosis that leads to cirrhosis. NAFLD and its comorbid conditions extend well beyond the liver. It is a multisystemic clinical disease entity with extrahepatic manifestations such as cardiovascular disease, type 2 diabetes, chronic kidney disease, hypothyroidism, polycystic ovarian syndrome, and psoriasis. Indeed, the most common causes of mortality in subjects with NAFLD are cardiovascular disease, followed by malignancies and then liver-related complications as a distant third. This review focuses on several of the key extrahepatic manifestations of NAFLD and areas for future investigation. Clinicians should learn to screen and initiate treatment for these extrahepatic manifestations in a prompt and timely fashion before they progress to end-organ damage.

show abstract

The preventive effect of sustained physical activity on incident nonalcoholic fatty liver disease

Abstract: This study shows an independent protective effect of PA at baseline on incident NAFLD after 4-year follow-up. Furthermore, sustained or increased PA had a preventive effect on incident NAFLD independent of VAT and IR.

Cited by 33 publications

References 49 publications

The Lifestyle Characteristics in Non-Alcoholic Fatty Liver Disease in the PERSIAN Guilan Cohort Study

The Lifestyle Characteristics in Non-Alcoholic Fatty Liver Disease in the PERSIAN Guilan Cohort Study

Randomized trial comparing effects of weight loss by liraglutide with lifestyle modification in non‐alcoholic fatty liver disease

Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease

Contact Info

Product

Resources

About