The Production and Metabolism of 3,5,3′-Triiodothyronine and 3,3′,5′-Triiodothyronine in Normal and Fasting Subjects*

Suda, Abhay K.; Pittman, Constance S.; Shimizu, Taeko; Chambers, Joseph B.

doi:10.1210/jcem-47-6-1311

Cited by 159 publications

(64 citation statements)

References 32 publications

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“…The particular sensitivity of T3 suggests that food restriction does not only affect thyroid secretion. A reduction of peripheral conversion of T4 to T3 has been reported in rats (Balsam and Ingbar, 1979 ;Chopra, 1980 ;Gavin et al, 1980 ;Balsam et al, 1981a, b ;Gavin and Moeller, 1983 ;Shank et al, 1984 (Suda et al, 1978 ;Hughes et al, 1984) and obese (Burman et al, 1979(Burman et al, , 1980Jaedig and Faber, 1982 ;Marugo et al, 1984) men and in sheep (Blum et al, 1980). However, during fasting reverse T3 levels dot not change (Blum and Kunz, 1981) or decrease (Tveit and Almlid, 1980) in calves.…”

Section: Introductionmentioning

confidence: 92%

“…However, during fasting reverse T3 levels dot not change (Blum and Kunz, 1981) or decrease (Tveit and Almlid, 1980) in calves. A decreased metabolic clearance rate of reverse T3 (Suda et al, 1978 ;Blum and Kunz, 1981) and an enhanced peripheral conversion of T4 to reverse T3 (Suda et al, 1978) have been reported in men and rats. This agrees with the increase in the value of the reverse T3/free T4 ratio observed during food restriction in the present work.…”

Section: Introductionmentioning

confidence: 95%

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Effects of food restriction on cortisol, TSH and iodothyronine concentrations in the plasma of the newborn lamb

Wrutniak¹,

Cabello²

1987

Reprod. Nutr. Dévelop.

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Summary. The influence of food restriction, applied from birth to 36 h post partum, on neonatal thyroid function was studied in newborn Limousin x Romanov lambs. The control animals (n = 18) had free access to the mother and suckled ad libitum. Restricted lambs (n = 16) were removed from the mother and received limited amounts of colostrum in proportion to birth weight ; 8 lambs were supplemented with lactose (30 g/I of colostrum).Plasma glucose and free fatty acid levels were significantly lower in restricted lambs, whereas urea levels were elevated. Plasma cortisol concentrations in control animals decreased during the period studied, but rose during the first 8 h of life in restricted lambs. Lactose supplementation only partially restored glucose and urea levels. Food restriction induced considerable modifications in neonatal thyroid function. The postpartum rise in plasma thyroid-stimulating hormone (TSH), thyroxine (T4) and free T4 levels occurring in control lambs was inhibited in restricted animals. However, the surge in plasma triiodothyronine (T3) levels was not affected, suggesting that this change was not related to physiological neonatal TSH hypersecretion. Thereafter, thyroid hormone concentrations decreased sharply during food restriction, whereas reverse T3 levels remained higher than in the controls. In response to these T4 and T3 deficiencies, plasma TSH levels rose only in lactose-supplemented animals.In agreement with the significant modifications in the values of the T3/free T4 and reverse T3/free T4 ratios, the abrupt changes in T3 and reverse T3 levels suggest that food restriction affected the peripheral conversion of T4 into T3 and reverse T3.Twelve hours after the onset of refeeding, plasma T4 and reverse T3 levels were restored, but not the T3 levels ; this agrees with results obtained in other animals.In conclusion, food restriction strongly affected neonatal thyroid function in lambs in terms of secretion and peripheral T4 conversion.Introduction.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 95%

Effects of food restriction on cortisol, TSH and iodothyronine concentrations in the plasma of the newborn lamb

Wrutniak¹,

Cabello²

1987

Reprod. Nutr. Dévelop.

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“…An increase was noted in humans (Azizi, 1978 ;Burman et al, 1979 ;Suda et al, 1978), birds (May, 1978 ;Almeida and Thomas, 1981) and rabbits (Takagi et al 1978), but rats (Chopra, 1980 ;Hastings and Zeman, 1979 ;Heinen et al, 1981), piglets (Slebodzinski et al, 1982) and ruminants (Bahnak et al, 1981 ;Blum et a/., 1980 ;Tveit and Almlid, 1980) show a decrease.…”

Section: Introductionmentioning

confidence: 98%

“…This may be because not enough samples were studied or that they were not collected at the exact postpartum time when the transient rise occurred. On the contrary, the frequent and precise sampling practiced by Davicco et al (1982) (Balsam and Ingbar, 1979 ;Kaplan and Utiger, 1978 ;Naito et al, 1981) and piglets (Slebodzinski et al, 1982), has been shown to result in a decrease of circulating T3 in these species (Chopra, 1980 ;Hastings and Zeman, 1979 ;Heinen et al, 1981 andSlebodzinski et al, 1982, respectively) ; this phenomenon has also been shown in humans (Azizi, 1978 ;Burman et al, 1979 ;Suda et al, 1978), adult sheep (Blum et al, 1980), growing bulls Tveit and Almlid, 1980), deer (Bahnak et al, 1981), chickens (May, 1978) …”

Section: Introductionmentioning

confidence: 99%

Neonatal levels of plasma thyroxine in male and female calves fed a colostrum or immunoglobulin diet or fasted for the first 28 hours of life

Grongnet¹,

Grongnet-Pinchon²,

Witowski³

1985

Reprod. Nutr. Dévelop.

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“…Lipid mobilization is accelerated during the earlier consisting of a reduction in plasma thyroid horpart of a period of energy restriction or fasting in mones (Suda et al, 1978;Stockholm et al, 1987) and man and animals. It is likely that the decrease in a probable decrease in sympathetic activity plasma insulin levels is the major factor involved in (Landsberg & Young, 1978), could also be partly the induction of lipid mobilization since insulin is a responsible for the weight-loss resistance usually potent antilipolytic hormone (Cahill et al, 1966;Lil-observed during obesity therapy.…”

Section: Introductionmentioning

confidence: 99%

Lipomobilizing effects of procaterol and yohimbine in the conscious dog: comparison of endocrinological, metabolic and cardiovascular effects

Valet¹,

Taouis²,

Tran³

et al. 1989

British J Pharmacology

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provoked an equivalent increase in plasma non-esterified fatty acids (+ 100%). Procaterol, but not yohimbine, induced hyperglycaemia (+ 120%). Plasma insulin was weakly enhanced by yohimbine (+ 120%) as compared to the increase given by procaterol (+ 500%). 4 Both drugs stimulated sympathetic nervous system activity, as indicated by the increased plasma noradrenaline concentration, but only yohimbine increased the plasma adrenaline level. 5 Cardiovascular measurements indicated that procaterol strongly enhances heart rate and transiently decreases mean blood pressure. Yohimbine exhibits a weaker effect on heart rate and slightly increases mean blood pressure. 6 The present work clearly indicates that lipid mobilization is enhanced during fasting in the dog by selective fl2-adrenoceptor stimulation or by Cc2-adrenoceptor blockade. This enhanced lipolytic effect may result either from a direct action of the drugs on the adrenoceptors of fat cells or from an activation of the sympathetic nervous system. Procaterol suffers major limitations since it strongly increases heart rate, immunoreactive insulin and glycaemia. On the other hand, yohimbine induces only minor modifications both in cardiovascular and endocrinological parameters.

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The Production and Metabolism of 3,5,3′-Triiodothyronine and 3,3′,5′-Triiodothyronine in Normal and Fasting Subjects*

Cited by 159 publications

References 32 publications

Effects of food restriction on cortisol, TSH and iodothyronine concentrations in the plasma of the newborn lamb

Effects of food restriction on cortisol, TSH and iodothyronine concentrations in the plasma of the newborn lamb

Neonatal levels of plasma thyroxine in male and female calves fed a colostrum or immunoglobulin diet or fasted for the first 28 hours of life

Lipomobilizing effects of procaterol and yohimbine in the conscious dog: comparison of endocrinological, metabolic and cardiovascular effects

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