The Profile of Anti-inflammatory Activity of Syzigium Aromaticum Volatile Oil in Lotion with Variation Composition of Oleic Acid and Propylene Glycol as Enhancer

Iriani, Fitriah Ardiawijianti; Sugihartini, Nining; Yuwono, Tedjo

doi:10.22146/tradmedj.27922

Cited by 6 publications

(7 citation statements)

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“…The addition of more propylene glycol generated better penetration-enhancing activity. This finding is in line with Rahmawati et al (2017) and Iriani et al (2017) that have proven how increasing the proportion of propylene glycol in the enhancer mixture can improve the anti-inflammatory effects of CBEO in water-soluble base and lotion.…”

Section: Resultssupporting

confidence: 91%

“…The enhancer in the O/W cream consists of 30% oleic acid and 70% propylene glycol. A higher proportion of propylene glycol can deliver a more effective CBEO penetration, which is in line with the results of Iriani et al (2017) and Rahmawati et al (2017).…”

Section: Resultssupporting

confidence: 89%

“…The addition of enhancers, i.e., a mixture of oleic acid and propylene glycol, can raise the permeability and flux of eugenol contained in CBEO emulsion gels (Kurniawan et al, 2018). Previous research has confirmed that it can increase the anti-inflammatory effects of CBEO formulated in a water-soluble base (Rahmawati et al, 2017) and a lotion base (Iriani et al, 2017). The mixture of oleic acid and propylene glycol provides a synergistic effect in facilitating the penetration of eugenol into the skin layer and increasing its anti-inflammatory capacity.…”

Section: Resultsmentioning

confidence: 87%

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Anti-inflammatory activity of essential oil of clove (Syzygium aromaticum) in O/W and W/O Creams

Sugihartini

Lestari²,

Yuliani

2019

Pharmaciana

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Previous studies have shown that the formulations of clove essential oil with a concentration of 5% in W/O cream and 2.5% in O/W cream have anti-inflammatory properties. The formulations are developed by adding enhancers, namely oleic acid and propylene glycol. The optimum compositions of oleic acid and propylene glycol are 50%:50% in W/O cream and 30%:70% in O/W cream. This study aimed to determine the effects of different compositions of creams on their anti-inflammatory activities. The creams were evaluated for their anti-inflammatory properties by using mice with croton oil-induced inflammatory. The mice were sacrificed, and the back skin was removed to make histopathologic preparations at the end of the three-day inflammatory induction to obtain data of epidermal thickness and the number of cells with COX-2 expression. The results showed that the addition of oleic acid and propylene glycol as enhancers increased the anti-inflammatory activity of both O/W and W/O creams. Since the O/W cream decreased the thickness of the epidermis and the number of cells with COX-2 expression more than the W/O cream, the formulation of essential oil of clove in O/W cream is concluded as a better anti-inflammatory than that of W/O cream.

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 87%

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Anti-inflammatory activity of essential oil of clove (Syzygium aromaticum) in O/W and W/O Creams

Sugihartini

Lestari²,

Yuliani

2019

Pharmaciana

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“…The amount of cell with COX-2 expression, inflammatory cell and epidermal thickness was decline after the application of formulation of essential oil of clove in water soluble base ointment and lotion that contain mixture of oleic acid and propylene glycol as enhancer. This happen when the amount of propylene glycol increased [22,23]. The mechanism of propylene glycol as an enhancer was by dissolving the keratin layer of the stratum corneum, interacting, and disrupting the arrangement of intracellular lipids in the stratum corneum.…”

Section: Resultsmentioning

confidence: 99%

THE ANTI-INFLAMMATORY ACTIVITY OF ESSENTIAL OIL OF CLOVE (Syzygium aromaticum) IN ABSORPTION BASE OINTMENT WITH ADDITION OF OLEIC ACID AND PROPYLENE GLYCOL AS ENHANCER

et al. 2019

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Background : The optimal concentration of essential oil of clove in absorption base ointment as anti-inflammatory has been studied. The developmentof formulations can be done by adding oleic acid and propylene glycol as enhancers. The purpose of this study was to determine the anti-inflammatoryactivity of the essential oil of clove in absorption base ointment formula by adding a mixture of oleic acid and propylene glycol as enhancers.Methods: In this study, the composition of oleic acid and propylene glycol was 100% oleic acid (FI), 50% oleic acid and propylene glycol (FII), and100% propylene glycol (FIII). The profile of the anti-inflammatory activity essential oil of clove was carried out using male of mice Balb/C strain whichwas induced inflammatory with croton oil on back of skin. After treatment, it was sacrificed and then was taken the back of skin to get histopathologicalpreparation. After that, the epidermal thickness, number of inflammatory cells, and cyclooxygenase (COX)-2 expression can be measured.Results : Based on the results of the test, it shows that FIII has the smallest of the amount of COX-2 expression, the number of inflammatory cells, andthe epidermal thickness so the addition of the composition enhancer provides good anti-inflammatory activity.Conclusion: The increasing concentration of propylene glycol caused the raising activity of essential oil of clove as anti-inflammatory.

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“…Pada penelitian sebelumnya, telah dilakukan penelitian yang menghasilkan data bahwa emulgel minyak atsiri bunga cengkeh tanpa penambahan enhancer pro pilen glikol dan asam oleat mempunyai karak teristik sifat fisik yang baik dan tidak menimbul kan iritasi pada kulit hewan uji (13), hasil yang sama juga terdapat dalam sediaan krim tipe M/A (14). Hasil penelitian antiinflamasi minyak atsiri bunga cengkeh pada sediaan lotion (15) dan sa lep larut air (16) menunjukkan hasil bahwa pem berian propilen glikol sebagai enhancer mampu menurunkan ekspresi sel COX-2 dan sel inflamasi serta ketebalan epidermis. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberi an enhancer asam oleat dan propilen glikol dalam emulgel untuk menaikkan kemampuan penetrasi emulgel minyak atsiri bunga cengkeh menembus lapisan kulit hewan uji menggunakan metode Simplex Lactice Design, sehingga didapatkan for mula emulgel dengan nilai flux, lag time, permea bilitas, dan koefisien difusi yang terbaik.…”

Section: Pendahuluanunclassified

Uji Transport Emulgel Minyak Atsiri Bunga Cengkeh dengan Penambahan Enhancer Propilen Glikol dan Asam Oleat

Kurniawan

Sugihartini

Yuwono

2019

MPI

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Kuncup bunga cengkeh mengandung senyawa eugenol yang merupakan minyak atsiri yang terbuktisebagai antiinflamasi. Untuk mendapatkan efek antiinflamasi yang optimal diperlukan suatu rancanganformulasi sediaan topikal berupa emulgel minyak atsiri bunga cengkeh (MABC) dengan penambahanenhancer kombinasi propilen glikol (PG) dan asam oleat (AO) yang dapat meningkatkan kemampuan eugenoldalam menembus lapisan kulit sehingga didapatkan daya antiinflamasi yang optimal dengan metodeSimplex Lattice Design (SLD). Diformulasikan 3 formula emulgel dengan perbandingan PG dan AO dalamemulgel: 100%:0% (FI); 50%:50% (FII); dan 0%:100% (FIII). Masing-masing formula dilakukan uji transportdengan alat uji difusi tegak Franz menggunakan media kulit punggung mencit dan ditetapkan kadarnyamenggunakan Kromatografi Cair Kinerja Tinggi (KCKT) serta diukur parameter uji transport yang meliputidaya permeabilitas, flux, koefisien difusi dan lag time. Data yang diperoleh dianalisis menggunakan metodeSLD. Analisis data yang diperoleh menunjukkan adanya peningkatan pada parameter flux, permeabilitas,dan koefisien difusi serta penurunan pada lag time secara signifikan pada emugel dengan enhancer dibandingkan emulgel tanpa penambahan enhancer propilen glikol dan asam oleat. Diperoleh formulasi optimum emulgel MABC dengan penambahan 100% enhancer propilen glikol sebagai formula yang mempunyai parameter flux, permeabilitas, koefisien difusi, dan lag time paling baik dan nilai enhancement ratio 1,05 – 1,94.

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The Profile of Anti-inflammatory Activity of Syzigium Aromaticum Volatile Oil in Lotion with Variation Composition of Oleic Acid and Propylene Glycol as Enhancer

Abstract: cengkeh, lotion, asam oleat, propilen glikol, antiinflamasi

Cited by 6 publications

References 1 publication

Anti-inflammatory activity of essential oil of clove (Syzygium aromaticum) in O/W and W/O Creams

Anti-inflammatory activity of essential oil of clove (Syzygium aromaticum) in O/W and W/O Creams

THE ANTI-INFLAMMATORY ACTIVITY OF ESSENTIAL OIL OF CLOVE (Syzygium aromaticum) IN ABSORPTION BASE OINTMENT WITH ADDITION OF OLEIC ACID AND PROPYLENE GLYCOL AS ENHANCER

Uji Transport Emulgel Minyak Atsiri Bunga Cengkeh dengan Penambahan Enhancer Propilen Glikol dan Asam Oleat

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