The Prognostic Role of Phase Angle in Advanced Cancer Patients: A Systematic Review

Pereira, Mayane Marinho Esteves; Queiroz, Mariana dos Santos Campello; Albuquerque, Nathália Masiero; Rodrigues, Juliana; Wiegert, Emanuelly Varea Maria; Calixto-Lima, Larissa; Oliveira, Lívia Costa de

doi:10.1002/ncp.10100

Cited by 52 publications

(37 citation statements)

References 34 publications

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“…In addition to a prognostic factor, this scale better demonstrates the patient's functionality, in addition to behavioral and social aspects, 20 and also makes up one of the PaP Score criteria, a tool used to estimate survival time in palliative care, used by doctors. 21,22 In addition to the factors pointed out in the present study, there are others that are described in the scientific literature as predictors of survival in patients with advanced cancer, among which we can mention the phase angle 23 (PA), the neutrophillymphocyte ratio (RNL) 24 and Score Glasgow modified prognosis (EPGm) 25 and some others.…”

Section: Discussionmentioning

confidence: 70%

Predictive Factors of Death on Hospitalization in Patients With Advanced Cancer in Palliative Care

Rosa

Cypriano

Albuquerque

et al. 2020

Am J Hosp Palliat Care

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Background: Prognostic assessment is essential to plan the care of patients with advanced cancer in palliative care. Objective: Thus, this study aims to assess the predictors of death in inpatients with advanced cancer in palliative care. Methods: This is a clinical, observational cohort study with patients aged >20 years, of both genders, evaluated within 48 hours of the first hospitalization. The independent variables were tumor location, nutritional risk [through the Patient-Generated Subjective Global Assessment (PG-SGA) short form], laboratory tests [C-reactive protein and albumin] and Karnofsky Performance Status (KPS). Logistic regression analyses were performed. Results: Eighty-two patients were evaluated, whose mean age was 61.8 (± 13.2) years. Forty-nine (59.8%) patients died during hospitalization, among which the majority had KPS of 30-40% (p-value = 0.043), higher means of the total score of the PG-SGA (p-value = 0.050) and lower serum albumin concentrations (p-value = 0.011). According to the multivariate model, tumor location in the gastrointestinal (GI) tract (OR: 1.73; 95% CI: 1.57 -1.94), 30-40% KPS (OR: 1.29; 95% CI: 1.07 -1.63) and albumin concentrations <3.5 g/dL (OR: 4.65; 95% CI: 1.22-17.7) were independent factors associated with an increased chance of death from hospitalization. Conclusion: Presenting an advanced tumor with localization in the GI tract, KPS ≤40% and serum albumin concentration <3.5 g/dL at admission were predictors of death in inpatients under palliative care.

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Section: Discussionmentioning

confidence: 70%

Predictive Factors of Death on Hospitalization in Patients With Advanced Cancer in Palliative Care

Rosa

Cypriano

Albuquerque

et al. 2020

Am J Hosp Palliat Care

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“…As an adjunctive finding, among the confounding variables possibly affecting the association between PhA and CRP, we also included adherence to the MD, a healthy, anti-inflammatory dietary pattern known to actively modulate cell membrane properties [ 17 , 63 ]. The ESPEN strongly recommended PhA as a prognostic nutritional measure [ 64 , 65 ], and reliable marker for the identification of inflammation in subjects at risk of impaired nutritional status [ 11 , 66 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

Phase Angle as an Easy Diagnostic Tool of Meta-Inflammation for the Nutritionist

et al. 2021

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Phase angle (PhA), a noninvasive bioimpedance marker, is a useful tool for nutritional screening in several diseases. C-reactive protein (CRP), a strong risk factor for metabolic and cardiovascular diseases, is a commonly used biomarker of meta-inflammation. As both PhA and CRP are influenced by age, BMI, and nutritional status, and exhibit a clear sex dimorphism, we examined the association between PhA and CRP levels in 1855 subjects (680 males and 1175 females), aged 18–59 years, with BMIs ranging from 19.5 to 69.4 kg/m2, stratified according to sex. PhA values and CRP levels were significantly lower in females than males (p < 0.001), while the adherence to the Mediterranean diet (MD) was lower in males compared to females (p < 0.001). After adjusting for age, physical activity, BMI, waist circumference, and adherence to the MD, PhA remained negatively associated with CRP levels in both genders (p < 0.001). In the ROC analysis, PhA ≤ 5.5° in males and ≤5.4° in females were the threshold values predicting increased hs-CRP levels. These results suggested that PhA might represent a valid predictor of CRP levels in both sexes regardless of body weight and adherence to the MD, which avoids the collection of blood sampling and expensive biochemical assays.

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“…Therefore, other objective parameters are needed to predict clinical outcomes. Bioelectrical impedance analysis (BIA) has recently attracted attention as a simple and noninvasive tool for objectively predicting clinical outcomes in cancer patients, by evaluating malnutrition and cancer cachexia (5,6). The BIA evaluation is performed by sending a weak electrical current through the body and measuring related parameters (7,8).…”

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confidence: 99%

The Association Between Extracellular Water-to-Total Body Water Ratio and Therapeutic Durability for Advanced Lung Cancer

Noda¹,

Suzuki²,

Kanai³

et al. 2020

Anticancer Res

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Background/Aim: Extracellular water-to-total body water ratio (ECW/TBW) measured by bioelectrical impedance analysis (BIA) reportedly predicts clinical outcomes of various diseases. The aim of this retrospective study was to examine the association between ECW/TBW and therapeutic durability of chemotherapy and/or immune checkpoint inhibitors in advanced lung cancer. Patients and Methods: Patients with advanced lung cancer underwent BIA before chemotherapy and/or treatment with immune checkpoint inhibitors at our hospital between June 2018 and November 2019. Results: Of 75 patients, 18 with ECW/TBW ≥0.4 were assigned to the overhydrated group (OH-G) and 57 patients ECW/TBW <0.4 were assigned to the non-overhydrated group (NOH-G). The median time-to-treatment failure was significantly shorter in the OH-G than in the NOH-G (p=0.003). Multivariate analysis revealed that ECW/TBW ≥0.4 predicted treatment failure [hazard ratio (HR)=2.508, 95% confidence interval (CI)=1.19-5.27; p=0.01]. Conclusion: The ECW/TBW may be an objective parameter for predicting therapeutic durability in advanced lung cancer.

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The Prognostic Role of Phase Angle in Advanced Cancer Patients: A Systematic Review

Cited by 52 publications

References 34 publications

Predictive Factors of Death on Hospitalization in Patients With Advanced Cancer in Palliative Care

Predictive Factors of Death on Hospitalization in Patients With Advanced Cancer in Palliative Care

Phase Angle as an Easy Diagnostic Tool of Meta-Inflammation for the Nutritionist

The Association Between Extracellular Water-to-Total Body Water Ratio and Therapeutic Durability for Advanced Lung Cancer

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