The prognostic significance of long noncoding RNAs in non-small cell lung cancer: a meta-analysis

Abstract

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The overall 5-year survival rate of patients is extremely low and to find a new marker is urgently needed. Numerous studies indicate that long noncoding RNAs (lncRNAs) abnormally express in cancers. However, the results have been disputed, especially in the aspects of tumor prognosis. Therefore, we performed this meta-analysis to systematically summarize the relationship between lncRNAs expression and NSCLC. A total of 34 eligible studies including 30 on overall survival, 10 on progression-free survival and 23 on clinicopathological features were identified from the databases. Our results indicated that the levels of lncRNAs were associated with the overall survival (OS; hazard ratios [HR], 1.43; 95% confidence interval [95% CI], 1.17-1.76; P < 0.001). However, there was no relationship between lncRNAs and progression-free survival (PFS; hazard ratios [HR], 1.55; 95% confidence interval [95% CI], 0.91-2.63; P = 0.11). Moreover, lncRNAs were related to lymph node metastasis (odds ratios [OR], 1.70; 95% confidence interval [95% CI], 1.03-2.80; P = 0.04), while no association was observed with other characteristics. In conclusion, our present meta-analysis indicated that lncRNAs transcription levels may serve as a promising marker for prognosis of patients with NSCLC.

Clinical roles of the aberrantly expressed lncRNAs in lung squamous cell carcinoma: a study based on RNA-sequencing and microarray data mining

“…LncRNAs have also been demonstrated to gain various functions in tumorigenesis of lung cancer. However, most of the studies concerned the general NSCLC, but few focused on LUSC [ 19 ]. Thus, identification of LUSC-related lncRNAs, and investigation of their clinical roles and molecular mechanisms are essential for understanding the development and progression of LUSC.…”

The prognostic significance of long noncoding RNAs in bladder cancer: A meta-analysis

“…More importantly, aberrant expression of multiple lncRNAs were found to be involved in the tumorigenesis and many of them were correlated with cancer prognosis [ 9 – 11 ]. Multiple lncRNAs have been reported to be promising prognostic indicators for cancers, such as hepatocellular carcinoma [ 12 ], non small cell lung cancer [ 13 , 14 ], osteosarcoma [ 15 ], ovarian carcinoma [ 16 ], and renal cell carcinoma [ 17 ]. So far, many studies have shown that lncRNAs also played critical roles in BC [ 18 ], these findings support that lncRNAs can be developed as novel potential prognostic biomarkers in patients with BC.…”

Clinicopathological and Prognostic Role of Long Noncoding RNA Linc00152 in Various Human Neoplasms: Evidence from Meta-Analysis

“…In spite the “junk” of genome lncRNAs being considered as insignificant, they are now confirmed to exert pivotal roles in tumor biological processes, including carcinogenic or antitumor effects via transcriptional and posttranscriptional regulations [ 6 , 7 ]. Furthermore, emerging evidence has indicated that the abnormal expression of lncRNAs was correlated with progression of neoplasms, including clinical-pathological features and prognostic outcomes [ 7 – 12 ]. Therefore, lncRNA can serve as a potential biomarker for predicting progression and survival in patients with carcinomas.…”