The Promoting Effect of Eucommiol from Eucommiae Cortex on Collagen Synthesis.

Li, Yanmei; Kamo, Sakurako; Metori, Koichi; Koike, Katsuya; Che, Qing–Ming; Takahashi, S.

doi:10.1248/bpb.23.54

Cited by 40 publications

(25 citation statements)

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“…Studies have shown the plant extracts of Eucommia ulmoides and Acalypha indica to promote collagen synthesis in vitro (Ganeshkumar et al 2012, Li et al 2000. This phenomenon could explain the healing claimed by the TMPs, since some of the medicinal plants documented in this study could be acting via the same mechanism.…”

Section: Possible Mechanism Of Action Of Some Of the Plants Used To Tsupporting

confidence: 55%

Medicinal Plant Species Used in the Management of Hernia by Traditional Medicine Practitioners in Central Uganda

Kibuuka

Anywar

2015

Ethnobot. Res. App.

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Section: Possible Mechanism Of Action Of Some Of the Plants Used To Tsupporting

confidence: 55%

Medicinal Plant Species Used in the Management of Hernia by Traditional Medicine Practitioners in Central Uganda

Kibuuka

Anywar

2015

Ethnobot. Res. App.

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“…The pharmacological effects of EuO leaves on bone and muscle are closely related to collagen metabolism (Li et al, 1998). Granuloma formation and collagen synthesis were significantly increased by the administration of methanol extracts of EuO cortex (Li et al, 2000a). A number of active EuO components, such as chlorogenic acid, geniposide, geniposidic acid, and aucubin, can influence osteoblast differentiation and slow bone loss.…”

Section: Discussionmentioning

confidence: 99%

“…Water extracts of EuO leaves have been reported to have potent antimutagenic effects (Nakamura et al, 1997;Lee et al, 2005;Luo et al, 2009). EuO extracts have also been reported to enhance collagen synthesis (Metori et al, 1997;Li et al, 2000a;2000b;Deyama et al, 2001). It is generally assumed that natural substances in EuO give rise to these beneficial effects.…”

Section: Introductionmentioning

confidence: 99%

Eucommia ulmoides Oliv. antagonizes H2O2-induced rat osteoblastic MC3T3-E1 apoptosis by inhibiting expressions of caspases 3, 6, 7, and 9

Lin

Fan

Mehl

et al. 2011

J. Zhejiang Univ. Sci. B

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Eucommia ulmoides Oliv. (EuO), also known as Duzhong, native to China, has been reported to have antioxidative function, but its cellular mechanism is not fully examined yet. We investigated inhibitory effects of EuO leaf ethanol extracts on H 2 O 2 -induced apoptosis in rat osteoblastic MC3T3-E1 cells and underlying mechanisms. Locally-grown Duzhong leaves were extracted with ethanol. MC3T3-E1 cells were treated with EuO (6.25, 12.5, 25, 50, and 100 µg/ml) for 24 h, and then H 2 O 2 (800 µmol/L) for an additional 24 h. Cell survival rate, percentage of apoptosis, and expressions of caspases 3, 6, 7, and 9 were examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, microscopic analysis, Western blotting, and reverse transcription polymerase chain reaction (RT-PCR). The final EuO leaf ethanol extract powder was detected to contain caffeotannic acid at 58 mg/g and geniposide at 3.45 mg/g by high performance liquid chromatography (HPLC). EuO remarkably restrained cell oxidative damage and increased cell survival rate in a dose-dependent manner: 0 µg/ml, 0.21; 6.25 µg/ml, 0. 28; 12.5 µg/ml, 0.31; 25 µg/ml, 0.48; 50 µg/ml, 0.54; and 100 µg/ml, 0.66 (P<0.05), with the half-effective concentration being around 25 µg/ml. MTT results were confirmed by microscopic analysis. Western blotting and RT-PCR analyses showed that the expressions of caspases 3, 6, 7, and 9 were significantly decreased in the EuO-treated cells compared with the control (EuO-and H 2 O 2 -free) (P<0.05), with the half-effective concentration of EuO ranging from 12.5 to 25 µg/ml. We conclude that the ethanol-extracted EuO leaf extracts promoted the growth of MC3T3-E1 cells, and suppressed the H 2 O 2 -induced apoptosis in a rat MC3T3-E1 osteogenic cell model, likely due to the inhibition of caspases' activities. The results indicate that EuO is a potent antioxidant, which may contribute to its many cellular protective functions, including the promotion of bone growth.

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“…3,12,13) In this study, there may be a possibility that the administration of E. ulmoides leaf extracts and GA affected the TEWL of UV-damaged hairless mouse skin (Figs. 3 and 5).…”

Section: Discussionmentioning

confidence: 96%

Herb extracts and collagen hydrolysate improve skin damage resulting from ultraviolet-induced aging in hairless mice

Jimbo

Kawada

Nomura

2015

Bioscience, Biotechnology, and Biochemistry

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We examined the effect of the daily ingestion of herb extract from Eucommia ulmoides leaves and Korean ginseng on skin damage induced by repeated UV irradiation of hairless mice. The herb extract was orally administered to mice at a dose of 1000 mg/kg/day. The hydration of mice dorsal skin decreased significantly with repeated UV irradiation, but did not decrease when the herb extract was administered for seven weeks. Transepidermal water loss (TEWL) increased with UV irradiation, but decreased with the administration of dietary herb extract. These effects were more pronounced when combined with the administration of collagen hydrolysate. Geniposidic acid from E. ulmoides leaves and ginsenoside Rg1 from Korean ginseng reduced TEWL and increased the skin moisture content of UV-damaged skin on hairless mice, respectively. We concluded that this dietary herb extract reduced the skin damage caused by UV-induced aging, with geniposidic acid and ginsenoside Rg1 detected in the blood.

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The Promoting Effect of Eucommiol from Eucommiae Cortex on Collagen Synthesis.

Cited by 40 publications

References 1 publication

Medicinal Plant Species Used in the Management of Hernia by Traditional Medicine Practitioners in Central Uganda

Medicinal Plant Species Used in the Management of Hernia by Traditional Medicine Practitioners in Central Uganda

Eucommia ulmoides Oliv. antagonizes H2O2-induced rat osteoblastic MC3T3-E1 apoptosis by inhibiting expressions of caspases 3, 6, 7, and 9

Herb extracts and collagen hydrolysate improve skin damage resulting from ultraviolet-induced aging in hairless mice

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