The properties of a new type 3 attenuated poliovirus

Vonka, V.; Janda, Z.; Simon, J.; Adam, Ervín; Závadová, H; Adamova, V.D.

doi:10.1007/bf01245241

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…As has been stated previously (11), the possibility is being considered that the differences in alimentary tract resistance observed could be associated with the significant differences in the intratypie antigenic character of the two strains tested (8) and with the strain specificity of neutralization antibodies elicited (14), which could act as the factor determining the extent and duration of intestinal infection. Regardless of other possible causes of the phenomenon observed, the present finding may deserve careful attention.…”

Section: Discussionmentioning

confidence: 97%

“…Details were given in previous papers (10,11). The vaccines used for feeding children were prepared from the viruses Leon 12alb and USOL-D bac.…”

Section: Methodsmentioning

confidence: 99%

“…Details concerning selection of children have been presented previously (11). Details concerning selection of children have been presented previously (11).…”

Section: Methodsmentioning

confidence: 99%

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Properties of a new type 3 attenuated poliovirus

Janda¹,

Adam²,

Vonka³

1967

Archiv f Virusforschung

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Section: Discussionmentioning

confidence: 97%

“…Details were given in previous papers (10,11). The vaccines used for feeding children were prepared from the viruses Leon 12alb and USOL-D bac.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Properties of a new type 3 attenuated poliovirus

Janda¹,

Adam²,

Vonka³

1967

Archiv f Virusforschung

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“…The intraeerebral tests in monkey and the evaluation of the findings were carried out as described previously (10). Two rhesus monkeys were used for testing eaeh virus.…”

Section: Isolation and Identi]ication Of The Viruses Ten Percent Stomentioning

confidence: 99%

Properties of a new type 3 attenuated poliovirus

Vonka

Janda

Simon

et al. 1965

Archiv f Virusforschung

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In a previous paper of ours (i) selection of new attenuated variants of type 3 poliovirus was described and their basic characteristics were compared with the respective properties of Loon 12alb (Sabin) and VV~I-3 (Koprowski) viruses. The results obtained indicated that one of the newly developed attenuated viruses, denoted as USOL-D bac virus, possessed a lower degree of residual neurotropism after intraspinal inoculation than the type 3 viruses of Dr. Sabin and Dr. Koprowski. Intraspinal administration of 10 s'~ TCDs0 of the virus (1) or even ten times higher doses (2) elicited no clinical disease and only minimal lesions in the lumbar cord without detectable spread to the other parts of CNS. On the basis of these results the USOL-D bae virus was chosen for preparing a vaccine for tests in human beings.With the experimental batch of vaccine, which was kindly prepared by Prof. M. P. Chumakov (Moscow) a series of studies were started designed particularly to investigate the genetic stability of the virus during passage in human beings, and its immunogenic activity in nonimmune children as well as in those which had been previously immunized with Sabin's vaccine. The present paper reports the results of the first smalLscate trial carried out with the USOL-D bae virus in a closed community of eMIdren fed in the past ~dth Sabin's tsq)e 3 virus. Materials and MethodsViruses. The viruses were the same as used in earlier experiments (1).Vaccine. The vaccine used in the present study was prepared from the USOL-D bac virus developed in this laboratory. The virus was submitted toProf. M. P. Chumakov (Institute of Poliomyelitis and Tick-Born Encephalitis

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Enterovirus Infections of the Central Nervous System: The Present and Future of Poliomyelitis

Horstmann

1967

Medical Clinics of North America

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The properties of a new type 3 attenuated poliovirus

Cited by 3 publications

References 5 publications

Properties of a new type 3 attenuated poliovirus

Properties of a new type 3 attenuated poliovirus

Properties of a new type 3 attenuated poliovirus

Enterovirus Infections of the Central Nervous System: The Present and Future of Poliomyelitis

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