The Properties of Iodine in Solutions of Surface-Active Agents ,

Allawala, Naseem A.; Riegelman, Sidney

doi:10.1002/jps.3030420703

Cited by 36 publications

(19 citation statements)

References 14 publications

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“…3 shows the distribution of hexachlorophane plotted as the degree of saturation of the true aqueous phase as suggested by Allawala & Riegelman (1953) and Mitchell (1964). Fig.…”

Section: Sucrose Laurate 1%mentioning

confidence: 97%

“…Allawala & Riegelman (1953) have shown that the capacity of such systems is increased when an increased concentration of antibacterial agent is used together with a solubiliser. Allawala & Riegelman (1953) have shown that the capacity of such systems is increased when an increased concentration of antibacterial agent is used together with a solubiliser.…”

Section: Antibacterial Activitymentioning

confidence: 99%

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Effect of solubilisation on the antibacterial activity of hexachlorophane

Anderson

Morgan

1966

Journal of Pharmacy and Pharmacology

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Macrogol Polyethylene polypropylene glycol Effect of solubilisation on the antibacterial activity Hard Macrogol, B.P.C. ; Polyethylene glycol 4000; Oxyethylene-oxypropylene polymer; Pluronic F 68 Union Carbide Wyandotte Chemicals Carbowax 4000Corp.The solubilisation of hexachlorophane by various non-ionic agents has been studied at p H 2.5 and 8.0. The interaction of the phenol with these agents in unsaturated systems at pH 8.0 has been determined by a dialysis technique using rubber latex membranes. The bactericidal activity is shown to depend on the concentration of unbound hexachlorophane, but this is not simply related to the degree of saturation of the total system. The results of agar-plate diffusion tests cannot be correlated with either the concentration of unbound hexachlorophane or the total concentration.ANY phenolic antiseptics have a low water solubility and because M of this are often used together with surface-active agents which

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“…3 shows the distribution of hexachlorophane plotted as the degree of saturation of the true aqueous phase as suggested by Allawala & Riegelman (1953) and Mitchell (1964). Fig.…”

Section: Sucrose Laurate 1%mentioning

confidence: 97%

Section: Antibacterial Activitymentioning

confidence: 99%

Effect of solubilisation on the antibacterial activity of hexachlorophane

Anderson

Morgan

1966

Journal of Pharmacy and Pharmacology

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“…It is generally accepted that preservative solubilized or bound within the micelles is inactive and, although the micelles act as a reservoir of preservative, the antimicrobial activity depends largely on the concentration of unbound or free preservative (Allawala & Riegelman, 1953 ;Pisano & Kostenbauder, 1959 ;Mitchell, 1964). Hence thephysicochemical parameter(s) used to express the interaction should permit calculation of the total preservative concentration required to provide a concentration of free preservative adequate to inhibit microbial growth.…”

mentioning

confidence: 98%

Interaction of preservatives with cetomacrogol

Kazmi

Mitchell

1971

Journal of Pharmacy and Pharmacology

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The interaction of a number of commonly used preservatives (benzoic acid, p‐hydroxybenzoic acid, methyl p‐hydroxybenzoate, propyl p‐hydroxybenzoate and chloroxylenol with the non‐ionic surfactant cetomacrogol was examined and a comparison made of various methods of expressing this interaction. It is suggested that the Scatchard equation is the most satisfactory equation for describing the binding data. Binding parameters determined from a Scatchard plot in the concentration range of free preservative appropriate for antimicrobial activity can be used to calculate the total concentration of preservative required in the surfactant system.

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“…2 Rather, IT is converted to iodide (I3) which acts as a reservoir of iodine (a reservoir that has not been shown to be active against biologic material). Yet, when this solution is titrated with sodium thiosulfate, this reservoir is depleted instantaneously, accounting for the fact that the amount of titratable ("available") iodine would be 1% (10,000 ppm).…”

mentioning

confidence: 99%

Iodine—Champagne in a Tin Cup

Favero

1982

Infect. Control

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The Properties of Iodine in Solutions of Surface-Active Agents ,

Cited by 36 publications

References 14 publications

Effect of solubilisation on the antibacterial activity of hexachlorophane

Effect of solubilisation on the antibacterial activity of hexachlorophane

Interaction of preservatives with cetomacrogol

Iodine—Champagne in a Tin Cup

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