The protection of Vitamin E and selenium against carbon tetrachloride-induced genotoxicity in ovine peripheral blood lymphocytes

Šiviková, Katarı́na; Piešová, Elena; Dianovský, Ján

doi:10.1016/s1383-5718(01)00190-5

Cited by 27 publications

(19 citation statements)

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“…Moreover Sivikova et al [44] described that an insufficient confirmation of the genitoxicity of CCl4 and the protective effect of the antioxidants, respectively were seen in cultures with metabolic activation.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Extra Virgin Olive Oil and Soybean on DNA, Cytogenicity and Some Antioxidant Enzymes in Rats

et al. 2014

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We investigated the effect of extra virgin (EV) olive oil and genetically modified (GM) soybean on DNA, cytogenicity and some antioxidant enzymes in rodents. Forty adult male albino rats were used in this study and divided into four groups. The control group of rodents was fed basal ration only. The second group was given basal ration mixed with EV olive oil (30%). The third group was fed basal ration mixed with GM (15%), and the fourth group survived on a combination of EV olive oil, GM and the basal ration for 65 consecutive days. On day 65, blood samples were collected from each rat for antioxidant enzyme analysis. In the group fed on basal ration mixed with GM soyabean (15%), there was a significant increase in serum level of lipid peroxidation, while glutathione transferase decreased significantly. Interestingly, GM soyabean increased not only the percentage of micronucleated polychromatic erythrocytes (MPCE), but also the ratio of polychromatic erythrocytes to normochromatic erythrocytes (PEC/NEC); however, the amount of DNA and NCE were significantly decreased. Importantly, the combination of EV olive oil and GM soyabean significantly altered the tested parameters towards normal levels. This may suggest an important role for EV olive oil on rodents’ organs and warrants further investigation in humans.

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Section: Discussionmentioning

confidence: 99%

The Effect of Extra Virgin Olive Oil and Soybean on DNA, Cytogenicity and Some Antioxidant Enzymes in Rats

et al. 2014

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“…Pathological changes following CCl 4 poisoning have been identified at the biochemical and the ultra structural level [57, 58]. …”

Section: Discussionmentioning

confidence: 99%

Phytomedicinal Role of Pithecellobium dulce against CCl₄‐mediated Hepatic Oxidative Impairments and Necrotic Cell Death

Manna

Bhattacharyya

Das

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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Present study investigates the beneficial role of the aqueous extract of the fruits of Pithecellobium dulce (AEPD) against carbon tetrachloride (CCl4)-induced hepatic injury using a murine model. AEPD has been found to possess free radical (DPPH, hydroxyl and superoxide) scavenging activity in cell-free system. CCl4 exposure increased the activities of various serum maker enzymes and intracellular reactive oxygen species (ROS) production. In line with these findings, we also observed that CCl4 intoxication increased the lipid peroxidation and protein carbonylation accompanied by decreased intracellular antioxidant defense, activity of cytochrome P450 and CYP2E1 expression. DNA fragmentation and flow cytometric analyses revealed that CCl4 exposure caused hepatic cell death mainly via the necrotic pathway. Treatment with AEPD both pre- and post-toxin exposure protected the organ from CCl4-induced hepatic damage. Histological findings also support our results. A well-known antioxidant vitamin C was included in this study to compare the antioxidant potency of AEPD. Combining all, results suggest that AEPD protects murine liver against CCl4-induced oxidative impairments probably via its antioxidative property.

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“…It acts as a free radical scavenger and among other effects, it has been proved to be an antigenotoxic agent in several mammalian cells [19][20][21][22][23][24][25]. In the present report we analyzed whether the deleterious cytotoxic and genotoxic effects exerted by dicamba and banvel ® is mediated by an oxidative damage.…”

Section: Introductionmentioning

confidence: 94%

Dicamba-induced genotoxicity in Chinese hamster ovary (CHO) cells is prevented by vitamin E

González

Soloneski

Larramendy

2009

Journal of Hazardous Materials

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The protection of Vitamin E and selenium against carbon tetrachloride-induced genotoxicity in ovine peripheral blood lymphocytes

Cited by 27 publications

References 28 publications

The Effect of Extra Virgin Olive Oil and Soybean on DNA, Cytogenicity and Some Antioxidant Enzymes in Rats

The Effect of Extra Virgin Olive Oil and Soybean on DNA, Cytogenicity and Some Antioxidant Enzymes in Rats

Phytomedicinal Role of Pithecellobium dulce against CCl₄‐mediated Hepatic Oxidative Impairments and Necrotic Cell Death

Dicamba-induced genotoxicity in Chinese hamster ovary (CHO) cells is prevented by vitamin E

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The protection of Vitamin E and selenium against carbon tetrachloride-induced genotoxicity in ovine peripheral blood lymphocytes

Cited by 27 publications

References 28 publications

The Effect of Extra Virgin Olive Oil and Soybean on DNA, Cytogenicity and Some Antioxidant Enzymes in Rats

The Effect of Extra Virgin Olive Oil and Soybean on DNA, Cytogenicity and Some Antioxidant Enzymes in Rats

Phytomedicinal Role of Pithecellobium dulce against CCl4‐mediated Hepatic Oxidative Impairments and Necrotic Cell Death

Dicamba-induced genotoxicity in Chinese hamster ovary (CHO) cells is prevented by vitamin E

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Phytomedicinal Role of Pithecellobium dulce against CCl₄‐mediated Hepatic Oxidative Impairments and Necrotic Cell Death