The protective effect of curcumin administration on carbon tetrachloride (CCl4)-induced nephrotoxicity in rats

Hişmioğulları, Adnan Adil; Hişmioğulları, Şahver Ege; Karaca, Oğuz; Sunay, Fatma Bahar; Paksoy, Serpil; Can, Mehmet; Kus, Iter; Seyrek, Kamil; Yavuz, Özlem

doi:10.1016/j.pharep.2014.10.021

Cited by 62 publications

(44 citation statements)

References 43 publications

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“…5), aggregations of inflammatory cells and marked inflammatory changes associated with fatty changes (Fig.6), focal necrotic areas, congestion and pyknotic nuclei were also observed (Fig.7). These observations agree with Manjrekar, Jisa, Bag, and Adikary (2008); Morsy et al (2012); Morakinyo, Oludare, Anifowose, and Adegoke (2012); Domitrovic et al (2015);and Hismiogullari et al (2015). Masson trichrome stained sections showed congested thickened portal tract with dense fibrous tissues radiating from the portal vein and extending into the parenchyma (Fig.…”

Section: Resultssupporting

confidence: 87%

“…13), severe congestion, vacuolation, inflammatory changes, and dilatation of Bowman's space with glomerular atrophy and periglomerular space (Figs. 14,15,16,and 17), this agree with Manjrekar et al (2008); Morakinyo et al (2012);and Hismiogullari et al (2015). Kidney sections obtained after the two routes of NAC treatment stained with H&E showed improvement in the architecture (Figs.…”

Section: Resultssupporting

confidence: 83%

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The protective effect of N-acetyl cysteine against carbon tetrachloride toxicity in rats

Foaud

Kamel

El-Monem

2018

JoBAZ

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Background: Carbon tetrachloride (CCL4) is used as a solvent for oils and fats, as a refrigerant, and as a dry-cleaning agent. Inhalation of its vapors can depress central nervous system activity and cause degeneration of the liver and kidneys. Aim: The aim of this study was to investigate whether N-acetyl cysteine (NAC) has a protective effect on the toxicity caused by carbon tetrachloride. Methods: Male rats were used in this experiment. Animals were divided into five groups, 5 animals each: G1 received olive oil, G2 was treated with CCL4 (1 ml/kg body wt) dissolved in olive oil (1:1), G3 received NAC (300 mg/kg body wt), G4 received CCL4 plus NAC, and G5 received NAC for 1 week then administrated to the same treatment of G4. All administrations were performed by gavage and maintained for 4 weeks. Results: The present study revealed that administration of CCL4 caused a significant increase in liver marker enzymes Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), and alkaline phosphatase (ALP); also, malondialdehyde (MDA) content in the liver tissue was increased. However, serum total protein showed no change in all groups. Also, histopathological investigation of CCL4 on the liver, testis, and kidney showed different deleterious effects. Additionally, CCl4 induced a highly significant increase in the percentage of sperm shape abnormality and sperm DNA tail moment values. Alternatively, result revealed that the two routes of NAC administrations caused a significant decrease in liver marker enzymes as well as MDA contents; improvement in liver, kidney, and testes architecture; a significant decrease in the percentage of sperm head abnormalities; and decline in the DNA tail moment values. Conclusion: The present study pointed out the protective effect of NAC against the toxicity of CCL4.

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Section: Resultssupporting

confidence: 87%

Section: Resultssupporting

confidence: 83%

The protective effect of N-acetyl cysteine against carbon tetrachloride toxicity in rats

Foaud

Kamel

El-Monem

2018

JoBAZ

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“…Also, the level of Alb decreased. This result is in coincidence with many other results obtained by different authors who used CCl 4 in their experiments (Hassan et al 2003;Hsiao et al 2003;Hismiogullari et al 2014;Kang andKoppula, 2014 andLu et al 2016).…”

Section: Discussionsupporting

confidence: 92%

Histological and biochemical studies on the effect of tetrodotoxin extracted from Puffer fish (Lagocephalus sceleratus) against carbon tetrachloride induced hepatotoxicity in albino mice.

Khalil¹,

Swelim²,

Zaky³

2018

Egypt. J. of Aquatic Biolo. and Fish.

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“…The comparative assessment between Group I and Control showed that Curcumin administration decreased oxidative stress by lowering the serum ABTS value. The values obtained validated the antioxidant effect of the tested substance (Curcumin) and are in agreement with previously published results (Gupta et al, 2009;Sharma et al, 2010;Sahin-Kavakli et al, 2011;Savcum et al, 2013;Hussein et al, 2014;Hismiogullari et al, 2014).…”

Section: Discussionsupporting

confidence: 91%

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

Coneac

Orăsan

Leucuţa

et al. 2017

Not Bot Horti Agrobo

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Curcumin, a natural phenolic compound is an anti-tumor agent with anti-inflammatory and anti-oxidant properties. The aim of this research was to evaluate oxidative stress levels, the antioxidant activity and Curcumin concentrations by high performance liquid chromatography (HPLC) in an acute experimental inflammation induced by Turpentine oil (intramuscular 0.6 mg kg -1 body weight) and to compare a prophylactic versus a therapeutic regimen of Curcumin (oral suspension of 150 mg Curcumin kg -1 rat weight). Sixteen adult male Wistar rats were assigned to four groups: Control, Group I (Curcumin only), Group II (Curcumin administration, then induced inflammation after 1 hour) and Group III (induced inflammation then Curcumin administration after 2 hours). Oxidative stress was assessed by measuring serum malondialdehide and carbonylated proteins, while systemic and local total antioxidant capacity was determined by ABTS. Local tissue changes (muscle, kidney, liver) were analysed using histopathology. Results showed that acute inflammation significantly increased lipid peroxidation in Groups II and III compared to Control and Group I. A significantly reduced total antioxidant capacity (ATBS) was present in serum and kidney in Group II, also in muscle and kidney in Group III. ABTS levels were significantly increased only in the liver tissue of the animals in Groups II and III with induced inflammation as compared to Group I. This study proved the potential of Curcumin in reducing oxidative stress in both prophylactic and therapeutic regimens.

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The protective effect of curcumin administration on carbon tetrachloride (CCl4)-induced nephrotoxicity in rats

Abstract: The finding of our study indicates that CUR may have an important role to play in protecting the kidney from oxidative insult.

Cited by 62 publications

References 43 publications

The protective effect of N-acetyl cysteine against carbon tetrachloride toxicity in rats

The protective effect of N-acetyl cysteine against carbon tetrachloride toxicity in rats

Histological and biochemical studies on the effect of tetrodotoxin extracted from Puffer fish (Lagocephalus sceleratus) against carbon tetrachloride induced hepatotoxicity in albino mice.

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

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