The finding of our study indicates that CUR may have an important role to play in protecting the kidney from oxidative insult.

Levels of five heavy metals [copper (Cu), lead (Pb), cadmium (Cd), chromium (Cr) and nickel (Ni)] were evaluated in liver and muscle tissues of fish (Mugil auratus) collected from the Black Sea at Sinop-Icliman, Turkey. Sampling and analysis methods are described. Variations of heavy metal concentrations with seasons are discussed. Cr and Ni concentrations were below the limits of detection (<0.05 and 0.1 ug/g dry weight) in all tissues and seasons. Cu, Pb and Cd were detected within these limits, as mg/kg dry weight, in liver tissue: 0.49-1.30, 0.60-1.21 and 0.15-0.50, and in muscle tissue: 0.30-1.00, 0.57-1.12 and 0.10-0.40, respectively. Cu, Pb and Cd concentrations in these tissues were elevated and the highest heavy metal concentrations were found in the liver. While Cu, Pb and Cd concentrations were highest in fish tissues collected in August 2000, the lowest concentrations of these metals were observed in fish tissues collected in May 2000. Pb had the highest level observed in fish tissues. According to the Turkish Food Codex Regulation's residue limits, the cadmium level determined in fish tissues was high (0.1 mg/g) and the lead level, especially in liver tissue, was high in August (1 mg/ g), while other metals (Cu, Cr and Ni) were within the maximum residue limits.

The effects of resveratrol on haematological and biochemical parameters were investigated in rats that had inflammation induced by experimental non-sterile clean wound technique. Twenty four male Wistar-Albino rats weighing 250-300 g were placed into three groups of eight after matching for age, sex and weight. In the sham-operated and resveratrol-treated groups, a 4-cm incision was made on the median line of the rats in order to create a wound. Resveratrol group was administrated resveratrol daily at a dose of 0.5 mg/kg/day for seven days. At the end of seven days, blood samples were obtained prior to sacrification and then analysed for hematological and biochemical parameters. The mean concentration of the inflammatory markers as CRP, WBC and LDH were significantly lower in resveratrol-treated group compared to the shame-operated group (P<0.05). Similarly, the mean values for WBC and LDH activity were significantly decreased in resveratrol-treated group compared to the control group (P<0.05). Resveratrol-treated group had significantly lower triglyceride concentration whereas sham-operated group had significantly higher glucose concentration when compared with the control values (P<0.001 and P<0.05, respectively). The results of the present study indicate that resveratrol attenuates inflammation and restores the alterations in blood chemistry induced by experimental clean wound inflammation in rats. Keywords: Resveratrol, Inflammation, Biochemical parameters, Haematological parameters, Wound Sıçanlarda Deneysel Oluşturulan Steril Olmayan Temiz Yara İnflamasyonunda Resveratrolün Koruyucu Etkisi ÖzetDeneysel steril olmayan temiz yara tekniği ile indüklenmiş inflamasyona sahip sıçanlarda, resveratrolün hematolojik ve biyokimyasal parametrelere olan etkisi araştırıldı. Yirmidört adet, 250-300 g ağırlığında Wistar-Albino sıçanları; yaş, cinsiyet ve ağırlıkları eşleşecek şekilde, 3 gruba yerleştirildi. Sham-operasyonu geçirmiş ve resveratrol almış gruplarda, sıçanların median hattı boyunca 4 cm'lik bir ensizyon yapılarak yara oluşturuldu. Resveratrol, 7 gün boyunca, 0.5 mg/kg/gün dozunda verildi. Yedi günün sonunda, hayvanlar öldürülmeden önce kan numuneleri alındı ve hematolojik ile biyokimyasal parametreler yönünden analiz edildi. Resveratrol almış grupta; CRP, WBC ve LDH gibi yangı belirteçleri, sham-operasyonu geçirmiş grup ile karşılaştırıldığında belirgin olarak düşüktü (P<0.05). Benzer şekilde, resveratrol almış grubun, WBC ve LDH aktivitelerinin ortalama değerleri, kontrol grubu ile karşılaştırıldığında, belirgin olarak düşüktü (P<0.05). Kontrol değerleriyle karşılaştırıldığında, resveratrol almış grup, belirgin olarak daha düşük trigliserid konsantrasyonuna sahipken, sham-operasyonu geçirmiş grup da belirgin olarak daha yüksek glukoz konsantrasyonuna sahipti (sırasıyla, P<0.001 ve P<0.05). Bu çalışmanın sonuçları, resveratrolün sıçanlarda inflamasyonu zayıflattığını ve kan kimyasında deneysel temiz yara inflamasyonu ile indüklenme sonucu oluşan değişiklikleri onardığını göstermektedir.

bsbd@balikesir.edu.tr www.bau-sbdergisi.com ÖZET Dioksin, organik klorlu (OK) bileşikler olarak bilinen, yüzlerce klorlu kimyasalın üretimi sırasında "ara" veya "yan ürün" olarak şekillenir. Çevrede son derece kalıcı özellikte olması nedeniyle hava, su ve toprağı önemli derecede kirleten bir işlem artığıdır. Canlılar, dioksinlere besin, su, solunum ve temas yolu ile maruz kalmaktadır. Fakat yağ dokuda birikme eğilimi gösteren dioksine uzun süre maruz kalınması, önemli sağlık sorunlarına yol açmaktadır. Bu nedenle, çevre ve gıda örneklerinde, dioksin ve benzeri kimyasalların varlıklarının ve düzeylerinin belirlenmesi, canlı sağlığının korunması ve çevre kirliliğinin önlenmesinde çok önemlidir.Anahtar Kelimeler: Dioksin, dioksin ve benzeri kimyasallar, TCDD, toksikoloji SUMMARY Dioxin is formed as "intermediate" or "by-product" during the production of hundreds of chlorinated chemicals known as organochlorine (OC) compounds. It is processing waste as well as strong air, water and soil pollutants due to its highly persistent property in environment. All living beings exposed to dioxins via food, water, inspiration and direct contact. However, the long-term exposure to dioxin that tends to accumulate in fatty tissues cause important health problems. Therefore, it is vital to determine the presence and levels of dioxin and dioxin-like chemicals in environmental and food samples for protecting health of living beings and preventing environmental pollution.

BACKGROUND: Commercial energy drink usage is reported to be higher in athletes and adolescents. However, the impact of pre-exercise consumption of energy beverages on hematologic and biochemical responses and skeletal muscle contractile properties has not been fully elucidated. METHOD: Ten male subjects performed 50 maximal eccentric actions on an isokinetic dynamometer at 90 • /sec followed by two identical trials that were preceded by consuming either a placebo (P) or energy drink (ED) beverage. The test was repeated after 7-10 days while consuming the alternate beverage. Complete blood counts and chemistry profile was conducted before and immediately after exercise. RESULTS: Eccentric contractions resulted in an increased number of neutrophils (Neut) and decreased lymphocytes (Lymph), decreased eosinophils (EOS) and did not change basophil (BASO) levels in control. However, the BASO levels increased immediately after the exercise with P and ED beverage consumption. In contrast, P and ED beverage consumption had no effect on Neut, Lymph, MONO or EOS counts after exercise compared to pre-exercise values. Acute exercise increased creatinine kinase (CK) and decreased phosphorus (Pi) but did not have any effect on other blood chemistry parameters. The biochemical profile and eccentric muscle contractile properties were not significantly affected by any of the beverages. CONCLUSIONS: Consumption of pre-exercise energy drink does not have a favorable effect on immune blood cells induced in the acute eccentric exercise model.