The protective effect of different airway humidification liquids to lung after tracheotomy in traumatic brain injury: The role of pulmonary surfactant protein-A (SP-A)

Computational and Mathematical Methods in Medicine

Wan

Chen

et al. 2022

Background. Continuous nursing based on 5E rehabilitation mode can improve the physiology and psychology of patients to some extent. The purpose of this study was to explore the effect of continuous nursing of 5E rehabilitation mode on the prevention and prognosis of severe respiratory tract infection in patients with severe tracheotomy in neurosurgery. Objective. To explore the effect of 5E rehabilitation nursing model on the prevention of severe respiratory tract infection and prognosis in patients with severe tracheotomy in neurosurgery. Methods. The starting and ending time of this study is from February 2019 to July 2021. In this paper, 60 patients with severe tracheotomy were divided into the control group and research group according to random number table method. The former group received routine nursing, and the latter group received rehabilitation nursing model based on 5E. The patients’ satisfaction, oxygenation index, partial pressure of carbon dioxide, partial pressure of oxygen, SAS, SDS score, incidence of severe respiratory tract infection, and quality of life scores were compared. Results. The nursing satisfaction of the research group was higher than that of the control group ( P < 0.05 ). 24 hours after weaning, the oxygenation index and partial pressure of oxygen in the research group were higher than those in the control group, while the partial pressure of carbon dioxide in the research group was lower than that in the control group ( P < 0.05 ). After nursing, the scores of self-rating anxiety scale and self-rating depression scale in the research group were lower than those in the control group, and the difference was statistically significant ( P < 0.05 ). The incidence of severe respiratory tract infection in the research group was significantly lower than that in the control group ( P < 0.05 ). After nursing, the scores of physiological function, psychological function, social function, and health self-cognition in the research group were lower than those in the control group ( P < 0.05 ). Conclusion. The nursing program of neurosurgical patients with severe tracheotomy based on 5E rehabilitation model can effectively enhance patients’ nursing satisfaction, activities of daily living, anxiety, and depression and promote the prognosis.

Section: Discussionmentioning

confidence: 99%

Prevention of Severe Respiratory Tract Infection and Prognosis in Neurosurgical Patients with Severe Tracheotomy Based on 5E Rehabilitation Nursing Model

Computational and Mathematical Methods in Medicine

Wan

Chen

et al. 2022

“…Post-stroke pneumonia, which is associated with a 49% increase in 1-year mortality, is also the most frequent complication in patients with ischemic stroke (de Montmollin et al, 2019). Except for administration of antibiotics for pulmonary infection, ambroxol, a small molecule chaperone, usually serves as an effective airway humidification liquid, which could improve lung function not only via facilitating the synthesis and secretion of pulmonary surfactant, but also through diluting sputum, thereafter, to promote pulmonary ventilation dysfunction and to inhibit further pulmonary damage, finally to enhance functional recovery after severe brain injury (Su et al, 2016). Thereafter, ambroxol is often applied to treat poststroke pneumonia after ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

Ambroxol Upregulates Glucocerebrosidase Expression to Promote Neural Stem Cells Differentiation Into Neurons Through Wnt/β-Catenin Pathway After Ischemic Stroke

Yang

et al. 2021

Front. Mol. Neurosci.

Ischemic stroke has been becoming one of the leading causes resulting in mortality and adult long-term disability worldwide. Post-stroke pneumonia is a common complication in patients with ischemic stroke and always associated with 1-year mortality. Though ambroxol therapy often serves as a supplementary treatment for post-stroke pneumonia in ischemic stroke patients, its effect on functional recovery and potential mechanism after ischemic stroke remain elusive. In the present study, the results indicated that administration of 70 mg/kg and 100 mg/kg enhanced functional recovery by virtue of decreasing infarct volume. The potential mechanism, to some extent, was due to promoting NSCs differentiation into neurons and interfering NSCs differentiation into astrocytes through increasing GCase expression to activate Wnt/β-catenin signaling pathway in penumbra after ischemic stroke, which advanced basic knowledge of ambroxol in regulating NSCs differentiation and provided a feasible therapy for ischemic stroke treatment, even in other brain disorders in clinic.

“…Pneumonia, occurring in 43% of all ICH patients, is a common complication heavily influencing outcome and accounting for more than 1/3 of the overall mortality in patients with ICH [3,4]. Except for antibiotic treatment, ambroxol has been proven to be an effective airway humidification liquid, which improves the patient's lung function through promoting the synthesis and secretion of pulmonary surfactant and diluting sputum to facilitate pulmonary ventilation dysfunction, thereafter, inhibiting further pulmonary damage after severe brain injury [5]. Hence, ambroxol was usually employed to protect lung against infection after ICH.…”

Section: Introductionmentioning

confidence: 99%

Ambroxol Improves Neuronal Survival and Reduces White Matter Damage through Suppressing Endoplasmic Reticulum Stress in Microglia after Intracerebral Hemorrhage

Jiang

BioMed Research International

Kou

et al. 2020

Intracerebral hemorrhage (ICH) has been becoming a serious public health problem. Pneumonia, occurring in 43% of all ICH patients, is a common complication heavily influencing outcome and accounting for more than 1/3 of the overall mortality in patients with ICH. Ambroxol may be an effective additional treatment for ICH patients with pneumonia. But its effect and potential mechanism on functional recovery post-ICH still remain elusive. In the present study, the results indicated that 35 mg/kg and 70 mg/kg ambroxol facilitated neuronal survival and reduced white matter fiber bundle damage due to mitigating microglial activation and reducing proinflammatory cytokine accumulation in mice with ICH. The possible mechanism might be due to suppressing endoplasmic reticulum stress involving the IRE1α/TRAF2 signaling pathway, which paves a new path for the treatment of ICH and opens a new window for the use of ambroxol in clinical practice.