The protective effect of erythropoietin on the acute phase of corrosive esophageal burns in a rat model

Bakan, Vedat; Garipardıç, Mesut; Okumuş, Mehmet; Çıralık, Harun; Atlı, Yalçın; Özbağ, Davut; Tolun, Fatma İnanç

doi:10.1007/s00383-009-2480-1

Cited by 15 publications

(20 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The latter suggests that the anti-fibrotic and anti-apoptotic effects of OLM administration in esophageal caustic burn observed in our study could be also attributed to the suppression of oxidative stress by AT1R antagonism. This hypothesis is in agreement with the results of previous studies which demonstrated partially successful treatment of caustic esophageal burns by increasing the antioxidant capacity of the tissue [25][26][27][28][29][30][31][32][33][34][35]. The present study provides new evidence that the renin-angiotensin system can be a promising target for the treatment of esophageal burns caused by corrosive agents.…”

Section: Discussionsupporting

confidence: 93%

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

Dereli

Krazinski

Ayvaz

et al. 2014

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

Accidentally ingested corrosive substances can cause functional and structural damage to the esophageal tissue resulting in stricture formation. It has been reported that the administration of olmesartan (OLM) can have anti-inflammatory, antifibrotic and antiapoptotic effects on injured tissue. The aim of our study was to check if OLM could prevent formation of scars in the corrosive esophageal burn model. Fifty-one Wistar Albino rats were divided into six groups: Control, Sham, OLM, Sham + OLM, Burn, and Burn + OLM. Olmesartan (5 mg/kg) was given by gavage once per day for 21 consecutive days after injury. The morphology of the esophagus was assessed after Masson trichrome staining, and apoptosis was evaluated using the terminal deoxynucleotidyl transferased UTP nick end labeling (TUNEL) method. The serum nucleosomes (as an indicator of apoptosis), serum p53 protein, and esophageal tissue p53 protein levels of each group were measured by immunoassays. Muscularis mucosa damage, submucosal collagen deposition, and tunica muscularis injury in the Burn + OLM group decreased significantly compared with the Burn group (p < 0.05). Similarly, the number of apoptotic cells in the Burn + OLM group decreased compared with the Burn group (p < 0.05). Serum levels of nucleosomes and p53 and tissue of p53 protein did not differ between the groups. Exogenously administered OLM can effectively prevent the occurrence of esophageal strictures caused by corrosive esophageal burns.

show abstract

Section: Discussionsupporting

confidence: 93%

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

Dereli

Krazinski

Ayvaz

et al. 2014

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

show abstract

“…Research has focused on the healing of the burned esophagus and reduction in collagen formation [9,10]. In animal experiments, a variety of different medications, such as erythropoietin, caffeic acid phenethyl ester, mitomycin C, ketotifen, and resveratrol have been used in attempt to prevent esophageal stricture formation after caustic ingestion [6][7][8][9][10]. We investigated the role of dexpanthenol and Y-27632, two different agents with different modes of action.…”

Section: Discussionmentioning

confidence: 99%

“…Corticosteroids, antibiotics, proton pump inhibitors, and H 2 receptor blockers are widely used in an effort to prevent stricture formation [1,4,5]. Ongoing experimental research continues to attempt to identify novel treatment strategies [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 98%

Protective Effects of Dexpanthenol and Y-27632 on Stricture Formation in a Rat Model of Caustic Esophageal Injury

Ceylan

Yapici

Tutar

et al. 2011

Journal of Surgical Research

View full text Add to dashboard Cite

“…EPO is a strong antioxidant (6), and it has been reported that EPO in crea sed the acti vi ty of antioxidant enzymes and de creased lipid per oxi dation (14,15). Furthermore, Bakan et al (16) sug gested that there was a direct relationship bet ween the levels of antioxidant enzymes and lipid peroxidation. In this study, EPO treatment increased TAC and PONX le vels and decreased TOA levels.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Erythropoietin on Bacterial Translocation and Inflammatory Response in an Experimental Intestinal Obstruction Model in Rats / Uticaj Eritropoetina Na Bakterijsku Translokaciju I Inflamatorni Odgovor U Eksperimentalnom Modelu Intestinalne Opstrukcije Kod Pacova

Kapan¹,

Önder²,

Yüksel³

et al. 2013

Journal of Medical Biochemistry

View full text Add to dashboard Cite

SummaryBackground: Intestinal obstruction results in distortion of balance of antiinflammatory cytokines and release of oxidants, and also leads to bacterial translocation, sepsis and multiple organ failure. Asymmetric dimethylarginine is related to multiple organ failure as a new prognostic marker. Erythropoietin reduces the inflammatory response by decreasing the levels of proinflammatory cytokines and cytokine-induced apoptosis. In this study, we aimed to investigate the effectiveness of erythropoietin in reducing the severity of bacterial translocation and inflammatory response after intestinal obstruction and the relation between asymmetric dimethylarginine and inflammatory markers. Methods: Forty Wistar albino rats (200-250 g) were divided into 4 groups as follows: Group 1 (Sham), only ileocaecal junction dissection; Group 2 (Erythropoietin), ileocaecal junction dissection and 3000 IU/kg erythropoietin subcutaneously; Group 3 (Intestinal Obstruction), complete ileal ligation; Group 4 (Intestinal Obstruction + Erythro poi e tin), complete ileal ligation and 3000 IU/kg erythropoietin subcutaneously. After 24 hours, the rats were sacrificed by taking blood from the heart for biochemical analyses. Peri to neal swab culture, liver, mesenteric lymph nodes, spleen and ileum were collected for microbiological and histopathological examinations. Results: Erythropoietin reduced the secretion of in flammatory cytokines, oxidative damage and bacterial translocation, prevented the formation of inflammatory changes in the intestine, liver, spleen and mesenteric lymph nodes,

show abstract

The protective effect of erythropoietin on the acute phase of corrosive esophageal burns in a rat model

Abstract: When administered early after an esophageal burn induced by 10% sodium hydroxide in this rat model, erythropoietin significantly attenuated oxidative damage, as measured by biochemical markers and histologic scoring.

Cited by 15 publications

References 44 publications

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

Protective Effects of Dexpanthenol and Y-27632 on Stricture Formation in a Rat Model of Caustic Esophageal Injury

The Effects of Erythropoietin on Bacterial Translocation and Inflammatory Response in an Experimental Intestinal Obstruction Model in Rats / Uticaj Eritropoetina Na Bakterijsku Translokaciju I Inflamatorni Odgovor U Eksperimentalnom Modelu Intestinalne Opstrukcije Kod Pacova

Contact Info

Product

Resources

About