The protective effect of hypothermia on the recovery of neural activity after deprivation of oxygen and glucose: study of slices from the hippocampus and superior colliculus

Posthypoxic Moderate Hypothermia Improves Electrophysiological Recovery in the Rat Hippocampal Slice

“…The evoked potential of CA1 pyramidal cells (population spike) has been shown to be a good indicator of cell function making it useful in quantifying the protective or toxic effects of the studied intervention. 11 This study indicated that postischemic moderate hypothermia (301C) protected against a shorter (3 min) duration of hypoxia but not against longer ones (3.5 or 4 min). Studies of protective effects of hypothermia against hypoxia in the hippocampal-slice model produced divergent results depending on the period of application of hypothermia, the degree of hypothermia and the brain region.…”