The protective effect of Punica granatum (pomegranate) against glaucoma development

Kamal, El-Nabarawy Salwa; Gomaa, Anhar M.; Aziz, Margeret A.; Ebrahim, Nadia Fathy; Ahmed, Shaimaa Saad

doi:10.4103/2278-0521.171429

Cited by 3 publications

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“…Pada beberapa hasil penelitian, buah delima menunjukkan berbagai aktivitas farmakologi di antaranya: antioksidan, antiinflamasi, antikanker, antiangiogenesis, antimutagenik, dan inhibitor pada beberapa enzim seperti siklooksigenase, lipooksigenasie, serta sitokrom P450 (Rahimi et al, 2012). Kamal et. al (2015) melaporkan bahwa buah delima memiliki aktivitas antiglaukoma.…”

Section: Pendahuluanunclassified

“…Pemberian simplisia buah delima konsentrasi 20% yang dicampurkan ke dalam pakan mampu menghambat peningkatan TIO hingga 62,5% pada kelinci model glaukoma. Penurunan TIO tersebut lebih besar dibanding ekstrak daun kumis kucing (pada tikus model glaukoma dengan dosis 36 mg/200g, persentase penurunan TIO 55,8%) dan ekstrak air Prunella vulgaris (pada kelinci model glaukoma dengan dosis 100 mg/kg, persentase penurunan TIO 54,5%) (Kamal et al, 2015;Siska dkk., 2012;Wu et al, 2017). Penurunan TIO diduga terjadi melalui penghambatan aktivitas enzim karbonik anhidrase sehingga menurunkan produksi cairan bola mata (Satomi et al, 1993).…”

Section: Pendahuluanunclassified

“…Kondisi tersebut tidak dapat dibandingkan secara langsung dengan hasil penelitian sebelumnya, karena hewan uji, induksi peningkatan tekanan intraokular serta dosis yang digunakan berbeda. Pada penelitian ini juga dibuktikan bahwa buah delima dapat menurunkan tekanan intraokular pada hewan uji yang mengalami peningkatan tekanan intraokular dan dapat pula digunakan untuk menghambat terjadinya glaukoma seperti yang telah dilaporkan oleh Kamal et al, (2015).…”

Section: Hasil Uji Aktivitas Penurunan Tekanan Intraokularunclassified

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Aktivitas Penurunan Tekanan Intraokular Kombinasi Ekstrak Etanol Buah Delima Dan Lidah Buaya

Fauzi¹,

Mardiah²

2021

J. Tumbuhan Obat Indonesia

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ABSTRACT Glaucoma is the second leading cause of blindness in the world. One of many strategies for controlling intraocular pressure to prevent blindness due to glaucoma is by inhibiting the production and/or increasing drainage of fluid in the eyeball. One of the potential natural remedies for such control is pomegranate (Punica granatum L.) and aloe vera (Aloe vera L.). This study aimed to evaluate the activity of lowering intraocular pressure of pomegranate and Aloe vera combination ethanol extracts in rats with ocular hypertension. Pomegranate and aloe vera were extracted by maceration method using 70% ethanol. Thirty rats were randomly divided into six groups, namely normal control group, rats with ocular hypertension control, drug control (acetazolamide 25 mg/kg BW p.o), pomegranate extract 500 mg/kg BW p.o, Aloe vera extract 500 mg/kg BW p.o, and extract combination p.o (each extract 500 mg/kg BW). Induction of ocular hypertension was performed by administering twelvedrops of 1% prednisolone acetate to the right eye. Intraocular pressure was measured using the schiotz tonometer before induction, after induction, and one hour after treatment. The combination of pomegranate and aloe vera extract given to rats with ocular hypertension showed a better potential to reduce intraocular pressure than a single administration of each extract, the percentage of reduction in intraocular pressure was 33.6±9.1%, 28.2±13.8%, and 29.9±8.1%, respectively. However, the combination of the two extracts did not show additive or synergistic effects and the potential of reducing intraocular pressure was lower than the acetazolamide drug. Keywords: Intraocular pressure, pomegranate, Aloe vera ABSTRAK Glaukoma merupakan penyebab kebutaan terbanyak ke dua di dunia. Strategi pengendalian tekanan intraokular untuk mencegah kebutaan akibat glaukoma dapat dilakukan dengan cara menghambat produksi dan atau melancarkan drainase cairan dalam bola mata. Salah satu sumber bahan baku alami yang potensial untuk pengendalian tersebut adalah buah delima (Punica granatum L.) dan lidah buaya (Aloe vera L.). Penelitian ini bertujuan untuk mengkaji potensi efek penurunan tekanan intraokular kombinasi buah delima dan lidah buaya pada tikus yang mengalami hipertensi okular. Buah delima dan lidah buaya diekstraksi dengan metode maserasi menggunakan etanol 70%. Secara acak, 30 ekor tikus dibagi kedalam 6 kelompok yaitu kelompok kontrol normal, kontrol tikus yang mengalami hipertensi okular, kontrol obat (asetazolamid 25 mg/kgBB p.o), ekstrak buah delima 500 mg/kgBB p.o, ekstrak lidah buaya 500 mg/kgBB p.o., kombinasi ekstrak p.o (masing – masing ekstrak 500 mg/kgBB). Induksi hipertensi okular dilakukan dengan pemberian 12 tetes prednisolon asetat 1% pada mata kanan. Tekanan intraokular diukur menggunakan tonomoter schiotz sebelum induksi, setelah induksi dan satu jam setelah pemberian perlakuan. Kombinasi ekstrak buah delima dan lidah buaya yang diberikan pada tikus yang mengalami hipertensi okular menunjukkan potensi yang lebih baik dalam menurunkan tekanan intraokular dibandingkan pemberian tunggal masing–masing ekstrak, persentase penurunan tekanan intra okular berturut-turut 33,6±9,1%, 28,2±13,8% dan 29,9±8,1%. Namun, pemberian kombinasi kedua ekstrak tersebut tidak menunjukkan efek aditif ataupun sinergis serta potensi dalam menurunkan tekanan intraokular masih dibawah obat asetazolamid. Kata kunci: Tekanan intraokular, buah delima, lidah buaya

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Section: Pendahuluanunclassified

Section: Hasil Uji Aktivitas Penurunan Tekanan Intraokularunclassified

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Aktivitas Penurunan Tekanan Intraokular Kombinasi Ekstrak Etanol Buah Delima Dan Lidah Buaya

Fauzi¹,

Mardiah²

2021

J. Tumbuhan Obat Indonesia

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“…There is limited data on the effect of pomegranate in eye diseases. In a rabbit model of chronic and moderately-elevated intraocular pressure (IOP), a significant decrease in IOP was observed in glaucoma rabbits treated with diet containing 20% pomegranate, which appeared to occur by maintaining the antioxidant defense system possibly by preventing depletion of antioxidant enzymes and inhibition of lipid peroxidation [25]. In a model of diabetic rats, those treated with 500 mg/kg body weight of pomegranate peel extract orally once per day with the drinking water for 40 weeks showed marked amelioration of pathological changes of the retina and lens compared with untreated rats [26].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Anti-Inflammatory Potential of Pomegranate Extract (Pomanox®) in a Reconstituted Human Corneal Epithelium Model

Peñalver‐Mellado

Silva-Fuentes²,

Villar³

et al. 2023

JCTO

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An in vitro study was conducted using a model of reconstituted human corneal epithelial (SkinEthic™ HCE/Human Corneal Epithelium) to test the modulation of cytokines secretion activity of Pomanox® (PMX), a standardized commercial extract of pomegranate fruit characterized by high punicalagin α + β content. Cell viability and inhibition of the release of interleukin-8 (IL-8) was evaluated in four conditions: negative control, positive inflammatory control with lipopolysaccharide (LPS) from Escherichia coli, positive anti-inflammatory control (LPS plus dexamethasone), and LPS plus PMX after 24 h of culture. The mean (±standard error of mean (SEM)) IL-8 level was 48.7 ± 5.1 pg/mL in the PMX condition vs. 172.7 ± 19.3 and 26.6 ± 1.2 in the LPS from E. coli and negative control, respectively (p < 0.05) and 93.8 ± 8.7 pg/mL in LPS plus dexamethasone (p = 0.165). The percentages of inhibition of IL-8 release were 45.7% for LPS plus dexamethasone and 63.8% for LPS plus PMX. The percentage of cell viability (86%) was also higher for the LPS plus PMX condition. The present findings add evidence to the anti-inflammatory effect of a PMX in an in vitro model of reconstituted corneal epithelial cells.

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Metabolomic Profile in the Aqueous Humor of Congenital Ectopia Lentis

Liu

Yiqing

et al. 2022

Current Eye Research

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N−stearoyl valine Eicosanoyl−EA Glabrol Phosphoglycolic acid O−Phospho−4−hydroxy−L−threonine 1−(Malonylamino)cyclopropanecarboxylic acid Phosphohydroxypyruvic acid Aspartyl−Histidine 2−Aminoethylphosphonic acid 2−Methoxybenzenethiol 3−Hydroxynitrazepam 2−Butanone, 4−[6−(sulfooxy)−2−naphthalenyl]− 2−[(Ethylthio)methyl]furan (R)−(+)−2−Pyrrolidone−5−carboxylic acid Oxoglutaric acid N−Acetyl−L−aspartic acid b−D−Glucopyranosiduronic acid Phenethylamine glucuronide S−Lactoylglutathione 2,7−Anhydro−alpha−N−acetylneuraminic acid Fructoselysine Voriconazole N−Desmethylzolmitriptan Streptamine phosphate N−(1−Deoxy−1−fructosyl)valine Hydroxypropionylcarnitine Mannopine N−(1−Deoxy−1−fructosyl)isoleucine N−(1−Deoxy−1−fructosyl)leucine hept−2−enedioic acid L−Ascorbic acid−2−glucoside Ethyl glucuronide 3−Hydroxyadipic acid Methyl5−(but−3−en−1−yl)amino−1,3,4−oxadiazole−2−carboxylate 3−Acrylamidopropyl trimethylammonium Alanyl−Arginine Mimosine 3−(1−Hydroxymethyl−1−propenyl)pentanedioic acid Diethyl Oxalpropionate Citrinin Graveolinine 1−(Indol−3−yl)propanol 3−phosphate Scandinone Monoglyceride citrate (R)−2−Hydroxybutane−1,2,4−tricarboxylate 4−Carboxy−4−hydroxy−2−oxoadipate Acetyl−D−carnitine Glycerol 1−propanoate diacetate N−(2−Hydroxyethyl)iminodiacetic acid Castanospermine Petunidin Pelargonidin SC−514 Flupyrsulfuron−methyl sodium 2−C−Methyl−D−erythritol 2,4−cyclodiphosphate erythro−8,10−Heptacosanediol OH−Diaponeurosporene glucoside ester PA(12:0/15:0) 4−Carboxy−4'−sulfoazobenzene Aminomalonic acid 3,5−DINITROCATECHOL (OR−486) N−Acetylaspartylglutamic acid 2−Aminoadenosine Ceriporic acid B 2−Fluorobenzoate Inosine Allopurinol−1−ribonucleoside Hypoxanthine gamma−Glutamyl−beta−aminopropiononitrile 1,5−Dibutyl methyl hydroxycitrate Ceriporic acid A 1−O−(2R−hydroxy−octadecyl)−sn−glycerol O−6−deoxy−a−L−galactopyranosyl−(1−>2)−O−b−D−galactopyranosyl−(1−>3)−2−(acetylamino)−1,5−anhydro−2−deoxy−D−arabino−Hex−1−enitol Bosentan N−methylundec−10−enamide (3R,6S)−3−Hydroxy−1,7−dioxaspiro[5.5]undecane Gabapentin 2−octenal 7−undecynoic acid 12−amino−dodecanoic acid 2−Dodecylbenzenesulfonic acid N−Undecylbenzenesulfonic acid Ro 31−7549 cis−Resveratrol 3−sulfate 9−B1−PhytoP Kynurenic acid Dibutyl phthalate Phthalic acid Uridine N−Methyl−4−pyridone−3−carboxamide dihydrocapsaicin Type IV cyanolipid 16:0 ester N−goshuyoyl lysine cis− and trans−5−Ethyl−4−methyl−2−(2−butyl)−thiazoline Ethyl 3−(N−butylacetamido)propionate 7−oxo−8−amino−nonanoic acid (E)−2−Butenyl−4−methyl−threonine PELLETIERINE Methylthiobenzoic acid Niacinamide (S,Z)−Lyratol acetate Coutaric acid Chrycolide Itaconic acid 4−(4−Deoxy−alpha−D−gluc−4−enuronosyl)−D−galacturonate 4−Nitroquinoline−1−oxide Leu−Leu−Tyr lipoamide Baclofen Propionylcarnitine 3,4−Dihydro−2H−1−benzopyran−2−one 3−(4−Methyl−3−pentenyl)thiophene L−Histidine D−(−)−Arabinose trans−2−[(Dimethylamino)methylimino]−5−[2−(5−nitro−2− furyl)−vinyl]−1,3,4−oxadiazole N−Acetylmuramoyl−Ala KINETIN RIBOSIDE (E)−C−HDMAPP Cystamine L−Acetylcarnitine DL−Acetylcarnitine Butyrylcarnitine 2−Carboxy−4−dodecanolide Chrycorin allopurin...

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The protective effect of Punica granatum (pomegranate) against glaucoma development

Cited by 3 publications

References 0 publications

Aktivitas Penurunan Tekanan Intraokular Kombinasi Ekstrak Etanol Buah Delima Dan Lidah Buaya

Aktivitas Penurunan Tekanan Intraokular Kombinasi Ekstrak Etanol Buah Delima Dan Lidah Buaya

In Vitro Anti-Inflammatory Potential of Pomegranate Extract (Pomanox®) in a Reconstituted Human Corneal Epithelium Model

Metabolomic Profile in the Aqueous Humor of Congenital Ectopia Lentis

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