The protective effect of quercetin on cyclophosphamide-Induced lung toxicity in rats

Şengül, Emin; Gelen, Volkan; Gedikli, Semin; Özkanlar, Seçkin; Gür, Cihan; Çelebi, Fikret; Çınar, Ali

doi:10.1016/j.biopha.2017.05.047

Cited by 66 publications

(47 citation statements)

References 19 publications

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“…During oxidative stress, enhancement production of ROS with pro-inflammatory cytokines can lead to cellular injury in the lung following cyclophosphamide intoxication. 26 In the present study, the concomitant administration of coenzyme Q10 with cyclophosphamide had a notable protective effect against cyclophosphamide-induced histopathological and biochemical effects on the lung tissue of adult male rats. This was in agreement with Ashry et al and Suddek et al who suggested that some types of antioxidants have health benefits that fight cyclophosphamide toxicity in lung tissue.…”

Section: Discussionsupporting

confidence: 48%

“…He added that biochemical and histological alterations induced by cyclophosphamide in experimental studies show similarity to those observed in humans. 26 Histological examination of the sections of the lung tissues of the rats of group III (cyclophosphamide treated group) revealed features of interstitial pneumonia associated with peribronchial, perivascular, and interstitial fibrosis and mononuclear inflammatory cells infiltration. This was clarified in both the H&E and Masson Trichrome stained sections.…”

Section: Discussionmentioning

confidence: 97%

“…Results of group III agree with Şengüla et al who reported alveolar cell injuries, thickness in alveolar septa, polymorphonuclear cells, and erythrocytes in the alveolar lumen in the lung sections of the cyclophosphamide treated group. 26 In the present study, the superoxide dismutase (SOD) activity in lung homogenates was assessed statistically in the lung tissue of different groups. The SOD activity of the lungs of group III (cyclophosphamide treated group) showed highly significant decrease when compared with those of the other groups (p<0.05).…”

Section: Discussionmentioning

confidence: 99%

“…Şengüla et al stated similar results in the cyclophosphamide treated group. 26 Moreover, Chakraborty et al and Choi et al reported that oxidative-stress-mediated cellular damages prevent freeradical scavenging enzymes, including SOD. 30,31 In addition, the malondialdehyde MDA levels as a marker of oxidative stress were also assessed statistically.…”

Section: Discussionmentioning

confidence: 99%

“…This was also in agreement with Şengüla et al who stated same results in the cyclophosphamide treated group. 26 Preiser stated that oxidative stress is an imbalance between the antioxidant and oxidant by excessive production of reactive oxygen species (ROS) and the ability of antioxidant systems to readily detoxify the ROS or repair the resulting damage. 32 Moreover, Şengüla et al added that oxidative enzymes are often used as indicators of oxidative stress in cells and can result in tissue damage.…”

Section: Discussionmentioning

confidence: 99%

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The potential protective role of coenzyme q10 on the cyclophosphamide-induced lung toxicity in adult male albino rats: a histological and ultrastructural study

2018

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Background: Cyclophosphamide is anticancer and immunosuppressant agent used to treat malignant and autoimmune diseases. Its long-term use causes side effects, as infertility and pulmonary toxicity. Coenzyme Q10; the only synthesized antioxidant in human body, acts as powerful antioxidant, scavenging free radicals, and inhibiting lipid peroxidation. Aim of present study was to examine effect of coenzyme Q10 on blood biochemical profiles, histopathological changes in lungs of adult rats exposed to cyclophosphamide-induced toxicity.Methods: 36 adult male albino rats divided into four groups; control and three experimental each having 9 rats. First experimental group received coenzyme Q10, second received cyclophosphamide while third group received coenzyme Q10 along with cyclophosphamide. Experiment lasted for 7 days. On 8th day, animals were sacrificed by decapitation. Lung tissue samples were collected for histopathological examination. SOD (superoxide dismutase) and MDA (malondialdehyde) levels were determined and used for statistical analysis. Results: In coenzyme Q10 treated group, H&E stained sections revealed normal respiratory alveoli. Ultrathin sections revealed normal alveolar septa, pneumocyte and blood capillaries contain erythrocytes. In cyclophosphamide treated group, H&E stained sections revealed peribronchial and interstitial fibrosis. Ultrathin sections revealed alveoli having apparent free lumen with extravasated erythrocytes. Alveolar septa revealed collagen fibrils deposits, and proliferated fibroblasts. In combined coenzyme Q10 and cyclophosphamide treated group, H&E stained sections revealed marked decrease of inter-alveolar tissue thickening. Ultrathin sections revealed destructed alveolar septa with dissociated remnants of collagen fibrils. Blood capillaries appeared wide, containing monocytes and erythrocytes.Conclusions: Administration of coenzyme Q10 with cyclophosphamide is advised to alleviate cyclophosphamide-induced lung toxicity.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The potential protective role of coenzyme q10 on the cyclophosphamide-induced lung toxicity in adult male albino rats: a histological and ultrastructural study

2018

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Uroprotective mechanism of quercetin against cyclophosphamide‐induced urotoxicity: Effect on oxidative stress and inflammatory markers

Sherif

2018

J of Cellular Biochemistry

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The urotoxicity is a common complication associated with patients receiving cyclophosphamide (CYP). This study was designed to investigate the uroprotective mechanism of quercetin (Quer) flavonoid against CYP induced urotoxicity via determination of oxidative stress markers as well as inflammatory mediators in bladder tissue. Forty male Wistar rats were divided into four groups; Normal group: received saline for 10 days. Quer control group: received quercetin 50 mg/kg/day for 10 days. CYP group: received saline for 10 days and injected with a single dose of 150 mg/kg CYP intraperitoneal (i.p) at day 8. The Quer + CYP group: received Quer 50 mg/kg/day for 10 days plus CYP 150 mg/kg i.p. injection at day 8. The CYP injection produced a significant elevation in bladder contents of malondialdehyde (MDA), and nitric oxide (NO), and bladder protein levels and expressions of tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) in addition to the upregulation of cyclooxygenase-2 (COX-2) bladder gene expression. Also, CYP injection showed a marked reduction in bladder levels of catalase, superoxide dismutase (SOD), and IL-10 when compared with normal group. Moreover, histopathological examination of the bladder showed degenerative alterations, severe edema, and inflammation following CYP injection. Quer attenuated the biochemical markers and histopathological changes induced by CYP. The uroprotective effect of Quer was exerted by restoring the balance between oxidative/antioxidative status and pro-/anti-inflammatory cytokines via its antioxidant and anti-inflammatory activities.

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Experimental and clinical studies on the effects of Portulaca oleracea L. and its constituents on respiratory, allergic, and immunologic disorders, a review

Khazdair

Saadat

Aslani

et al. 2021

Phytotherapy Research

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Various pharmacological effects for Portulaca oleracea were shown in previous studies. Therefore, the effects of P. oleracea and its derivatives on respiratory, allergic, and immunologic diseases according to update experimental and clinical studies are provided in this review article. PubMed/Medline, Scopus, and Google Scholar were searched using appropriate keywords until the end of December 2020. The effects of P. oleracea and its constituents such as quercetin and kaempferol on an animal model of asthma were shown. Portulaca oleracea and its constituents also showed therapeutic effects on chronic obstructive pulmonary disease and chronic bronchitis in both experimental and clinical studies. The possible bronchodilatory effect of P. oleracea and its ingredients was also reported. Portulaca oleracea and its constituents showed the preventive effect on lung cancer and a clinical study showed the effect of P. oleracea on patients with lung adenocarcinoma. In addition, a various constituents of P. oleracea including, quercetin and kaempferol showed therapeutic effects on lung infections. This review indicates the therapeutic effect of P. oleracea and its constituents on various lung and allergic disorders but more clinical studies are required to establish the clinical efficacy of this plant and its constituents on lung and allergic disorders.

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The protective effect of quercetin on cyclophosphamide-Induced lung toxicity in rats

Cited by 66 publications

References 19 publications

The potential protective role of coenzyme q10 on the cyclophosphamide-induced lung toxicity in adult male albino rats: a histological and ultrastructural study

The potential protective role of coenzyme q10 on the cyclophosphamide-induced lung toxicity in adult male albino rats: a histological and ultrastructural study

Uroprotective mechanism of quercetin against cyclophosphamide‐induced urotoxicity: Effect on oxidative stress and inflammatory markers

Experimental and clinical studies on the effects of Portulaca oleracea L. and its constituents on respiratory, allergic, and immunologic disorders, a review

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