The protective effect of Scenedesmus dimorphus polysaccharide as an antioxidant and antiaging agent on aging rat model induced by D-galactose

Armaini, Armaini; Imelda, Imelda

doi:10.7324/japs.2021.110508

Cited by 3 publications

(4 citation statements)

References 31 publications

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“…As mentioned earlier, enhancing the growth of S. dimorphus through the optimization of growth parameters plays an important role in its better exploitation for various applications. For instance, S. dimorphusis expansively used in biodiesel production as its cell contains 90% of diesel and polysaccharides S. dimorphus are proven to have an anti-skin aging property in an animal model 18,19 . Therefore, the present study is necessary for the production of S. dimorphus for above mentioned applications.…”

Section: Discussionmentioning

confidence: 99%

“…Biological applications of S. dimorphus are immense, and their rich nutrients and bioactive compounds made them extensively used as nutraceuticals and food supplements. As a nutraceuticals, S. dimorphus helps in repairing bone marrow damage and Omega-3 polyunsaturated fatty acids present in S. dimorphus play a significant role in preventing and treating diabetes, hypertension, cancer, autoimmune and heart diseases 11 .…”

Section: Fig 1: Morphology S Dimorphous (Utex 1237) Cells Observed Un...mentioning

confidence: 99%

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Untitled

2023

IJPSR

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Scenedesmus dimorphus isone of the widely exploited microalgae in several arenas of science, such as in food, nutraceuticals, agriculture, and pharmaceutical industries due to its high nutritional content and bioactivities. The present study designed a novel, cost-effective, eco-friendly, easy-to-operate and rectangular photobioreactor using glass material. Photobioreactor was provided with monochromatic LED light of 3000, 5000, 10,000 and 15,000 lux, agitation, and aeration facility. The effect of inoculum concentration, pH, temperature, and light intensity on the growth of S. dimorphus was evaluated in a novel photobioreactor. Finally, to convert dairy waste into valuable bioresources, dairy waste's effect on microalgae growth was investigated in an optimized condition using a novel photobioreactor. The optimum inoculum concentration to obtain the highest growth of S. dimorphus was 1-2x10 7 cells/ml in proteose peptone medium (pH 6.8) at 20ºC with photoperiodicity of Dark/Light (D/L) 12/12h and 12,000 lux.In similar experimental conditions, S. dimorphus revealed maximum growth at pH 7.0 and the optimum light intensity was 15,000lux.Growth temperature optimization in optimum conditions with D/L 12/12h indicated significant growth at 20ºC. The dairy waste at 50% resulted in the highest growth of S. dimorphusin optimum conditions. The growth of S. dimorphus was increased with increased incubation days indicating the highest growth on the 28 th day. Therefore, it is inferred that optimum physical parameters and nutrient-rich dairy waste play a significant role in enhancing the growth of S. dimorphus, which is extensively used in various fields of science. INTRODUCTION:As a consequence of the Global population explosion in the 1950s, such as poverty, famine, and migration, food production remarkably increased after that to fulfill the need of the growing population 1 . Though we have become self-sufficient regarding food needs, lack of nutrients in our daily life is a big concern.

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Section: Discussionmentioning

confidence: 99%

Section: Fig 1: Morphology S Dimorphous (Utex 1237) Cells Observed Un...mentioning

confidence: 99%

Untitled

2023

IJPSR

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“…Hwang et al (2019) revealed that it protects cells against apoptosis triggered by superoxide by converting the compound to O 2 and peroxide. Armaini and Imelda (2021) showed that SOD can be increased by giving Scenedesmus dimorphus polysaccharides (SDP) at a dose of 0.8 mg/g BW. The administration of SDP can stimulate collagen synthesis, repair skin tissue, increase catalase activity, and reduce malondialdehyde better compared to vitamin E. Furthermore, SDP shows benefits as an antioxidant and antiaging agent.…”

Section: Group Auc Value Collagen Percentage Gain Level (%)mentioning

confidence: 99%

Antiphotoaging effects of liposomal encapsulated superoxide dismutase extract of Bacillus altitudinis on ultraviolet-A-irradiated New Zealand rabbits’ back skin

Nurfitriyawatie¹,

Indrayati²,

Rukmana³

et al. 2023

J App Pharm Sc

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Photoaging can occur due to sunlight exposure that emits ultraviolet-A rays. Therefore, this study aims to assess the antiphotoaging activity of superoxide dismutase (SOD) extract of Bacillus altitudinis liposomes on rabbit back skin. The liposomes were encapsulated using the film method. The antiphotoaging test was carried out on the back skin of New Zealand rabbits which were separated into four groups, namely normal, negative, and positive controls, as well as liposome B. altitudinis. They were then exposed to ultraviolet-A (UV-A) light for 2 weeks. The treatment was carried out by applying liposome extract of B. altitudinis to the back skin of rabbits once a day for 28 days. Observations were made to assess the increase in the percentage of collagen, elasticity, and moisture content. The dorsal skin of the test animals was observed histologically using van Gieson staining. The results showed that rabbits exposed to UV-A light for 2 weeks experienced a decrease in collagen, elasticity, and moisture contents. Liposomes of B. altitudinis can increase the collagen level elasticity and moisture content by 6.46%, 5.10%, and 26.90%, respectively. The histological staining revealed that B. altitudinis liposomes increased collagen levels by 36.62%. These results indicate the potential value of B. altitudinis liposomes as photoaging agents.

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“…The content of folic acid and pigments that function as antioxidants from S. dimorphus can treat aplastic anemia in rats, by increasing blood hematological parameters and repairing bone marrow damage [17] . S. dimorphus contains betaglucan, which is an active immunostimulator and has beneficial effects as free radical scavengers, to reduce blood lipids [18] , and can also prevent skin aging [19] . S. dimorphus as a nutraceutical can treat degenerative neurons in Alzheimer's disease, Parkinson's disease, heart disease, cancer, and other degenerative diseases, such as diabetes, obesity, and anemia.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Lipid Profile and Liver Function After Administration of Scenedesmus dimorphus in Obese Mice

2022

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Obesity is a major public health problem in developing countries and is a significant risk factor for metabolic disorders. Microalgae Scenedesmus dimorphus (S. dimorphus) contains bioactive compounds such as pigment function as antioxidants, and omega-3 and omega-6 PUFAs have potential as nutraceuticals. The study aimed to evaluate the lipid profile and liver function after the administration of S. dimorphus in obese mice. The research design uses mice which are divided into 6 groups; Group 1 (G1) normal control, G2 control Obesity, G3 treatment with Orlistat, G4 treatment S. dimorphus (0.25mg/g BW), G5 treatment S. dimorphus (0.5 mg/g BW) and G6 treatment S. dimorphus (0.75 mg/g BW) each group consisted of 5 mice and 21 days of observation time. The parameters observed were lipid profile and liver function of mice. Based on the results of the study, the effective dose for treating obesity is a dose of S. dimorphus 0.75 mg/g (BW) can reduce cholesterol, triglycerides, and LDL levels, respectively 67.7 mg/dl, 49.2 mg/dl, 10 , 2 mg/dl, and increased HDL, 68.32 mg/dl compared to control of obesity (G2), respectively 108.7 mg/dl, 139.1 mg/dl, 20.6 mg/dl and HDL 60, 28 mg/dl, this dose is also effective for improving the function of blood pressure by reducing AST and ALT 15.6 U/L and 18.8 U/L, respectively, compared to the obesity group (G2), which is 26.6 U/L, and 29,7 U/L. Based on the results of the study it can be concluded that S. dimorphus is useful for anti-obesity for mice (Mus musculus).

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The protective effect of Scenedesmus dimorphus polysaccharide as an antioxidant and antiaging agent on aging rat model induced by D-galactose

Cited by 3 publications

References 31 publications

Untitled

Untitled

Antiphotoaging effects of liposomal encapsulated superoxide dismutase extract of Bacillus altitudinis on ultraviolet-A-irradiated New Zealand rabbits’ back skin

Evaluation of Lipid Profile and Liver Function After Administration of Scenedesmus dimorphus in Obese Mice

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