The protective efficacy of soursop fruit extract against hepatic injury associated with acetaminophen exposure is mediated through antioxidant, anti-inflammatory, and anti-apoptotic activities

Albrakati, Ashraf; Fouda, Manar S.; Tharwat, Ahmed; Elmahallawy, Ehab Kotb; Kassab, Rami B.; Moneim, Ahmed E. Abdel

doi:10.1007/s11356-019-04935-3

Cited by 22 publications

(13 citation statements)

References 39 publications

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“…The kidney plays an important role in metabolism and excretion of chemicals and drugs, as it contains most common xenobiotic detoxifying enzymes [19]. Xenobiotic-induced renal injury is dependent on the chemical nature of the xenobiotic, the dose, and the duration of exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, CPF has also been shown to activate apoptosis through upregulation of proapoptotic proteins in liver tissue [41]. Antioxidant treatment has been strongly linked with inhibition of chemical-induced apoptosis [19]. RBR coadministration with CPF exerted antiapoptotic activity through upregulation of Bcl-2 and downregulation of Bax and caspase-3.…”

Section: Discussionmentioning

confidence: 99%

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Nephroprotective Role ofBeta vulgarisL. Root Extract against Chlorpyrifos-Induced Renal Injury in Rats

Albasher

Almeer

Alarifi

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Organophosphorus pesticides (OPs) are widely used for agricultural and housekeeping purposes. Exposure to OPs is associated with the progression of several health issues. Antioxidant agents may be powerful candidates to minimise adverse reactions caused by OPs. The aim of the present study was to evaluate the nephroprotective effects of red beetroot extract (RBR) against chlorpyrifos- (CPF-) induced renal impairments. CPF induced kidney dysfunction, as demonstrated by changes in serum creatinine and urea levels. Moreover, CPF exposure induced oxidative stress in the kidneys as determined by increased malondialdehyde and nitric oxide levels, decreased glutathione content, decreased catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase activities, and decreased nuclear factor (erythroid-derived 2)-like-2 factor expression. In addition, CPF induced inflammation in renal tissue as evidenced by increased release of tumor necrosis factor-alpha and interleukin-1β and upregulation of inducible nitric oxide synthase. Furthermore, CPF promoted cell death as demonstrated by decreased Bcl-2 and increased Bax and caspase-3 levels. Treatment with RBR one hour prior to CPF treatment blocked the effects observed in response to CPF alone. Our results suggest that RBR could be used to alleviate CPF-induced nephrotoxicity through antioxidant, anti-inflammatory, and antiapoptotic activities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nephroprotective Role ofBeta vulgarisL. Root Extract against Chlorpyrifos-Induced Renal Injury in Rats

Albasher

Almeer

Alarifi

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Ionizing radiation (IR), a recognized proinflammatory agent, can cause oxidative stress, inflammation, p53 induction, DNA damage, mutagenesis, and oxidation of various molecules such as lipids and proteins [ 19 – 21 ]. IL-4, IL-6, IL-10, and TNF- α are representative inflammatory factors, PKC, HSP, ALP and DAO are products of stress reaction, and both of them are all sensitive to radiation and have response to radiation stress [ 21 – 23 ]. The current study demonstrated that IR (6 Gy) decreased the body weight gain, the number of nucleated cells in bone marrow, spleen index, and the screen of sIgA both in colon and serum, indicating immune function descent.…”

Section: Discussionmentioning

confidence: 99%

Guiqi Baizhu Decoction Alleviates Radiation Inflammation in Rats by Modulating the Composition of the Gut Microbiota

Zhang

Zhou

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The gut microbiota is important in metabolism and immune modulation, and compositional disruption of the gut microbiota population is closely associated with inflammation caused by ionizing radiation (IR). Guiqi Baizhu decoction (GQBZD) is a medicinal compound used in traditional Chinese medicine with anti-inflammatory and antioxidation effects, especially in the process of radiotherapy. However, the effect of GQBZD on reducing the damage to the normal immune system in radiotherapy remains unclear. Here, we show that GQBZD reduces body weights, water intake, food intake, diarrhea level and quality of life score, and inflammation and enhances immunity function in rats treated with X-ray radiation. Meanwhile, our data indicate that GQBZD not only reverses IR-induced gut dysbiosis as indicated change of α-diversity and β-diversity of microbiota, the composition of Desulfovibrio, Bacteroides, and Parabacteroides, except for Roseburia and Lachnoclostridium, but also maintains intestinal barrier integrity and promoting the formation of short-chain fatty acids (SCFAs). GQBZD can also reduce the level of phosphorylation P65 (p-P65). Our results demonstrate that GQBZD can significantly alleviate the inflammatory responses and improve the immune damage against IR, and may be used as prebiotic agents to prevent gut dysbiosis and radiation-related metabolic disorders in radiotherapy.

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“…Moreover, Bcl‐2 family protein has been demonstrated to be engaged with the regulation of ADM‐instigated apoptosis in cardiac tissues of rats. Bcl‐2 itself goes about as an apoptosis repressor, while another individual from the family, Bax, works as a promoter of cell passing . It has recently been accounted for that cardio toxicity initiates a checked decrease in the anti‐apoptotic protein, Bcl‐2 expression and an expansion in the apoptotic‐advancing molecule, Bax expression.…”

Section: Discussionmentioning

confidence: 99%

“…Bcl-2 itself goes about as an apoptosis repressor, while another individual from the family, Bax, works as a promoter of cell passing. 49,50 It has recently been accounted for that cardio toxicity initiates a checked decrease in the anti-apoptotic protein, Bcl-2 expression and an expansion in the apoptotic-advancing molecule, Bax expression. In concurrence with past examinations, our discoveries exhibited a noteworthy Bax up-regulation and Bcl-2 down regulation in rodents exposed to ADM actuated cardio toxicity.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of rosiglitazone, a peroxisome proliferator gamma agonist on adriamycin‐induced cardio toxicity via suppressing oxidative stress and apoptosis

Zhang

et al. 2019

IUBMB Life

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We investigated the rosiglitazone (RSG) effect on adriamycin (ADM)‐induced cardio toxicity in experimental animals. Forty adult Wistar male rats were separated into four groups as follows: normal control; RSG (10 mg/kg)‐treated; ADM (10 mg/kg)‐administered; and ADM (10 mg/kg) + RSG (10 mg/kg)‐treated. Serum lipid level, different biochemical biomarkers, histological analysis, and nuclear factor erythroid 2‐related factor/heme oxygenase‐1 (Nrf2/HO‐1), Caspase 3, B‐cell lymphoma 2 (Bcl‐2), and Bax gene expression were assessed in serum and cardiac tissue samples. Our results show that RSG treatment in ADM‐administered animals significantly diminished low‐density lipoprotein cholesterol, triglyceride, and total cholesterol, and increases high‐density lipoprotein cholesterol (HDL‐c) in comparison with the ADM group. RSG treatment reduced the effect of ADM administration on cardiac dysfunction markers such as cardiac troponin T Creatine Kinase‐MB, aspartate aminotransferase, and lactate dehydrogenase, showing the amelioration of cardio toxicity in ADM‐administered rats. Additionally, RSG treatment significantly decreased the level of malondialdehyde and nitric oxide in cardiovascular tissue. RSG‐treated rats in combination with ADM likewise showed a significant increase in reduced glutathione, superoxide dismutase, catalase content, and the activity of glutathione peroxidase (GPx) as compared with ADM group. Moreover, RSG treatment in ADM rats significantly increased an Nrf2 and HO‐1 expression in comparison with ADM group. While in apoptosis parameters, RSG treatment in ADM rats significantly diminished a cleaved caspase‐3 and Bax expression as well as expanded Bcl‐2 expression when contrasted with ADM group of rats. In conclusion, RSG is capable of protecting heart toxicity in ADM‐treated animals through defensive effects on oxidative stress and biochemical markers.

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The protective efficacy of soursop fruit extract against hepatic injury associated with acetaminophen exposure is mediated through antioxidant, anti-inflammatory, and anti-apoptotic activities

Cited by 22 publications

References 39 publications

Nephroprotective Role ofBeta vulgarisL. Root Extract against Chlorpyrifos-Induced Renal Injury in Rats

Nephroprotective Role ofBeta vulgarisL. Root Extract against Chlorpyrifos-Induced Renal Injury in Rats

Guiqi Baizhu Decoction Alleviates Radiation Inflammation in Rats by Modulating the Composition of the Gut Microbiota

Ameliorative effect of rosiglitazone, a peroxisome proliferator gamma agonist on adriamycin‐induced cardio toxicity via suppressing oxidative stress and apoptosis

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