The Quantitative Detection of Phenylephrine in Pharmaceutical Preparations and Spiked Human Urine by Voltammetry

Yağmur, Sultan; Türe, Melike; Sağlikoğlu, Gülşen; Sadıkoğlu, Murat

doi:10.1134/s1023193518100063

Cited by 14 publications

(12 citation statements)

References 15 publications

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“…Here, we report TiO 2 polycrystalline sub-micron fibers prepared with different rutile fractions ranging from 0 wt% to 100 wt% by adjusting their calcination temperature. These fibers were applied to the photocatalytic degradation of a model pharmaceutical agent, phenazopyridine [2,6-diamino-3-(phenylazo)-pyridine hydrochloride, (PAP)] (Scheme 1), which is used commercially as an analgesic for urinary tract infections [35,36]. To our knowledge, this is the first study on optimization of photocatalytic performance of electrospun TiO 2 fibers with different rutile 5 fractions.…”

Section: Introductionmentioning

confidence: 99%

Photocatalytic activity of TiO2 polycrystalline sub-micron fibers with variable rutile fraction

Liu

McCarthy

Cowan

et al. 2016

Applied Catalysis B: Environmental

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TiO 2 polycrystalline sub-micron fibers can be used as photocatalysts for the degradation of a variety of organic molecules. Here we report on the optimization of these fibers for decontaminating pharmaceutical agents in aqueous medical waste streams. Mixed-phase TiO 2 fibers have been prepared via a sol-gel technique followed by electrospinning and calcination. By adjusting the calcination temperature, the rutile phase fraction in TiO 2 fibers can be tuned relative to the anatase phase from 0% to 100%. The effect of rutile phase fraction on grain size and specific surface area as well as their subsequent influences on the photocatalytic activity was investigated. An optimal grain size in post-calcined TiO 2 fibers was found to be critical to balance the e-/h + volume recombination, surface recombination rate, and charge diffusion rate. The photocatalytic activities of the post-calcined TiO 2 fibers with different rutile fractions were measured by monitoring the decreasing concentration of phenazopyridine in aqueous solution under UV illumination using UV-Vis absorption spectroscopy. Post-calcined TiO 2 fibers composing of 38 wt% rutile and 62 wt% anatase exhibited the highest initial degradation rate constant of 0.044 min-1. This optimal photocatalytic activity can be attributed to the combined influences of the fibers' phase composition, surface area and grain size.

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Section: Introductionmentioning

confidence: 99%

Photocatalytic activity of TiO2 polycrystalline sub-micron fibers with variable rutile fraction

Liu

McCarthy

Cowan

et al. 2016

Applied Catalysis B: Environmental

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“…Multi-walled carbon nanotubemodified carbon paste electrode [13] voltammetry 8 × 10 -6 -1 × 10 -4 M 2.07 × 10 -7 M Use of ultra-trace graphite electrode (UTGE) [14] Potentiometric ionselective electrodes 1.0 × 10 −4 -1.0 × 10 −2 M 6.31 × 10 −5 M…”

Section: Methodsmentioning

confidence: 99%

Paper microfluidic device and spectrophotometry methods for colorimetric detection of phenylephrine hydrochloride in pure and pharmaceutical preparations

Abdulsattar¹,

Hadi²

2022

Bull. Chem. Soc. Eth.

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ABSTRACT. Two easy-to-use, rapid, and inexpensive colorimetric-based assays for the detection of active constituent in nasal decongestant phenylephrine hydrochloride (PHP), in solution and their respective pharmaceutical preparations were reported. The assay principle depends on the diazotized sulfadimidine (DSDM) coupling with PHP active pharmaceutical compound under alkaline conditions to produce a colored azo-dye product. A UV/VIS spectrophotometry method was utilized to monitor the color absorbance change at 460 nm, with a linear calibration graph in the concentration range of 1-20 mg L-1 and a limit of detection of 0.22 mg L-1 and limit of quantification of 0.72 mg L-1. A comparison was done using a paper-based microfluidic analytical device (µPADs) and color intensity change was measured using a Samsung note 9 camera to capture digital images and Image J software to analyze the color intensity development. A linear trend was observed above approximately 10 mg L-1. Thus, paper-based microfluidic analytical devices (µPADs) can be used as an alternative platform to conventional methods to perform a semi-quantitative PHP drug analysis. The proposed method was applied for the determination of PHP in commercial pharmaceutical preparations. KEY WORDS: Phenylephrine hydrochloride, Spectrophotometry, Paper-based microfluidic analytical devices (µPADs), Pharmaceutical preparations, Colorimetric detection Bull. Chem. Soc. Ethiop. 2022, 36(4), 727-736. DOI: https://dx.doi.org/10.4314/bcse.v36i4.1

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“…The values of LOD and LOQ were calculated as 2.8x10 -7 and 8.4x10 -7 mol L -1 respectively. A good repeatability and reproducibility of the anodic peak current and potential were calculated from five independent measurements for 1 x10 -5 mol L -1 clomipramine hydrochloride (Skrzypek et al, 2005;Çıtak et al, 2007;Yılmaz et al, 2013;Yagmur et al, 2017;Eker et al, 2017). Repetability peak current and peak potential were found as 1.79 and 0.76 respectively.…”

Section: Calibration Plots For the Determination Of Clomipramine Hyromentioning

confidence: 99%

“…Slope and r of the slope is related with lineartiy. It will be better to put linearity knowledge in here (Çıtak et al, 2007;Skrzypek et al, 2005;Yılmaz et al, 2013;Yagmur et al, 2017;Eker et al,2017).…”

Section: Calibration Plots For the Determination Of Clomipramine Hyrochloridementioning

confidence: 99%

Determination of Clomipramine Hydrochloride From Its Commercial Drug Form by Voltammetry

Ugurlu¹,

Yağmur²

2018

Health Sci. Q.

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In this study, electroanalytical technique was developed for the quantitative analysis of clomipramine hydrochloride from its commercial tablet dosage forms based on its oxidation behavior. The electrochemical determination of clomipramine hydrochloride was easily carried out on glassy carbon electrode (GCE) by two voltammetric techniques. The electrochemical measurements were carried out on GCE surface in different buffer solutions in the pH range from 2.00 to 12.00 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The effect of pH on the anodic peak current and peak potential was investigated. Phosphate buffer (pH 6.50) was selected for analytical purposes. The diffusion-controlled nature of the peak was obtained. A linear calibration plot for DPV analysis was constructed in the clozapine concentration range from 5x10-6 mol L-1 to 3x10-5 mol L-1. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 2.8x10-7 mol L-1 and 8.4x10-7 mol L-1 respectively.

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The Quantitative Detection of Phenylephrine in Pharmaceutical Preparations and Spiked Human Urine by Voltammetry

Cited by 14 publications

References 15 publications

Photocatalytic activity of TiO2 polycrystalline sub-micron fibers with variable rutile fraction

Photocatalytic activity of TiO2 polycrystalline sub-micron fibers with variable rutile fraction

Paper microfluidic device and spectrophotometry methods for colorimetric detection of phenylephrine hydrochloride in pure and pharmaceutical preparations

Determination of Clomipramine Hydrochloride From Its Commercial Drug Form by Voltammetry

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