1947
DOI: 10.1084/jem.85.1.117
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The Rapid Production of Acute Disseminated Encephalomyelitis in Rhesus Monkeys by Injection of Heterologous and Homologous Brain Tissue With Adjuvants

Abstract: 1. A picture resembling acute disseminated encephalomyelitis in the human being has been regularly and rapidly produced in rhesus monkeys by injection of emulsions of adult rabbit and monkey brain administered with adjuvants. 2. No lesions of the central nervous system resulted from injection of similar emulsions of fetal rabbit brain or adult rabbit lung. 3. A description of the gross and histological findings in the central nervous system is given and compared with features of h… Show more

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Cited by 375 publications
(83 citation statements)
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“…On immunization with various tissues in FCA autoimmune diseases are produced, e.g. whole brain (Kabat et al, 1947: experimental allergic encephalomyelitis) or whole testis (Voisin et al, 1951: experimental allergic orchitis). It should be emphasized that these lesions tend to be self-limiting rather than self perpetuating.…”
Section: Results (Table)mentioning
confidence: 99%
“…On immunization with various tissues in FCA autoimmune diseases are produced, e.g. whole brain (Kabat et al, 1947: experimental allergic encephalomyelitis) or whole testis (Voisin et al, 1951: experimental allergic orchitis). It should be emphasized that these lesions tend to be self-limiting rather than self perpetuating.…”
Section: Results (Table)mentioning
confidence: 99%
“…The disease exhibits relapsing and remitting symptoms including disturbances in vision, speech, coordination, and cognition as well as weakness, spasticity, and paralysis (1,2). Lymphocytic infiltration in the CNS white matter and immune reactions against myelin Ags indicate an autoimmune etiology for MS (1)(2)(3)(4)(5)(6)(7)(8). Allergic encephalomyelitis was first observed as a side effect of the rabies vaccine prepared from rabbit brains by Pasteur in the 1880s (see Ref.…”
Section: Ultiple Sclerosis (Ms)mentioning
confidence: 99%
“…Allergic encephalomyelitis was first observed as a side effect of the rabies vaccine prepared from rabbit brains by Pasteur in the 1880s (see Ref. 3). Rivers and others showed that the CNS inflammation was caused not by the rabies virus but by immune sensitization to the combination of adjuvant and brain tissue contaminating the vaccine (3,4).…”
Section: Ultiple Sclerosis (Ms)mentioning
confidence: 99%
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