The Rate Law and Mechanism of the Reaction of Iodine with Thiosulfate Ion: The Formation of the Intermediate S2O3I-

Awtrey, Alice D.; Connick, Robert E.

doi:10.1021/ja01147a147

Cited by 44 publications

(26 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Awtrey & Connick (158) find the rate law for the reaction of 12 with S203--in agreement with that of Dodd & Griffith (159). The mechanism proposed is I3-+ 5203---=21-+ 520.1-(fast) 52031-+ 5203---� 1-+ 5.0s--44.…”

supporting

confidence: 76%

Reaction Kinetics

Powell¹

1952

Annu. Rev. Phys. Chem.

View full text Add to dashboard Cite

Since scientific papers which could be catalogued as reaction kinetics are currently being published at a rate of more than a thousand per year, a simple bibliography of one year's pUblications would fill the space allotted this review. Fortunately for the reviewer, many papers fall into special fields such as photochemistry, polymerization, contact catalysis, isotopic studies, or biochemical kinetics, which will be reviewed separately in the present volume or succeeding volumes of the Annual Review of Physical Chemistry.

show abstract

supporting

confidence: 76%

Reaction Kinetics

Powell¹

1952

Annu. Rev. Phys. Chem.

View full text Add to dashboard Cite

show abstract

“…It was convincingly proven by Awtrey and Connick [11] that the oxidation of thiosulfate by iodine proceeds through an intermediate, and -in the Ϫ S O I , 2 3 presence of is also formed. They found that the rate constant of the hydrolysis of these anions are on the order of In spite of the Ϫ3 Ϫ1…”

Section: Identification Of the Intermediatementioning

confidence: 93%

Kinetics and mechanism of the reaction between hypochlorous acid and tetrathionate ion

Horváth

Nagypál²

2000

Int. J. Chem. Kinet.

View full text Add to dashboard Cite

show abstract

“…An iodine/thiosulfate indicator system based on the work of Nagata et al was employed (Awtrey and Connick, ; Nagata et al, ; Takahashi et al, ). Briefly, a 0.22 μm polyethersulfone‐filtered solution of 0.7% starch in 0.6 mM I 2 , 316 mM KI was loaded into a reactor and the flow pattern established.…”

Section: Methodsmentioning

confidence: 99%

High throughput screening of particle conditioning operations: I. System design and method development

Noyes

Huffman

Godavarti

et al. 2015

Biotech & Bioengineering

View full text Add to dashboard Cite

The biotech industry is under increasing pressure to decrease both time to market and development costs. Simultaneously, regulators are expecting increased process understanding. High throughput process development (HTPD) employs small volumes, parallel processing, and high throughput analytics to reduce development costs and speed the development of novel therapeutics. As such, HTPD is increasingly viewed as integral to improving developmental productivity and deepening process understanding. Particle conditioning steps such as precipitation and flocculation may be used to aid the recovery and purification of biological products. In this first part of two articles, we describe an ultra scale-down system (USD) for high throughput particle conditioning (HTPC) composed of off-the-shelf components. The apparatus is comprised of a temperature-controlled microplate with magnetically driven stirrers and integrated with a Tecan liquid handling robot. With this system, 96 individual reaction conditions can be evaluated in parallel, including downstream centrifugal clarification. A comprehensive suite of high throughput analytics enables measurement of product titer, product quality, impurity clearance, clarification efficiency, and particle characterization. HTPC at the 1 mL scale was evaluated with fermentation broth containing a vaccine polysaccharide. The response profile was compared with the Pilot-scale performance of a non-geometrically similar, 3 L reactor. An engineering characterization of the reactors and scale-up context examines theoretical considerations for comparing this USD system with larger scale stirred reactors. In the second paper, we will explore application of this system to industrially relevant vaccines and test different scale-up heuristics.

show abstract

The Rate Law and Mechanism of the Reaction of Iodine with Thiosulfate Ion: The Formation of the Intermediate S₂O₃I^-

Cited by 44 publications

References 1 publication

Reaction Kinetics

Reaction Kinetics

Kinetics and mechanism of the reaction between hypochlorous acid and tetrathionate ion

High throughput screening of particle conditioning operations: I. System design and method development

Contact Info

Product

Resources

About