The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance: The Korean Genomic Rural Cohort Study

Yoon, Jin Ha; Park, Jong Ku; Oh, Sung Soo; Lee, Ki Hyun; Kim, Sung Kyung; Cho, In Jung; Kim, Jong Koo; Kang, Hee-Taik; Ahn, Sung Gyun; Lee, Junwon; Lee, Seung Hwan; Eom, Aeyong; Kim, Jang Young; Ahn, Song Vogue; Koh, Sang Baek

doi:10.1016/j.cca.2011.08.003

Cited by 39 publications

(26 citation statements)

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“…Recently, leptin/adiponectin was proposed as a biomarker that may serve as a potential atherogenic index in obese T2DM patients [15], and it provides adjunctive information to the risk of MS beyond the HOMA-IR [16]. In our one-factor model, leptin/adiponectin was, after WC, the second highest factor loading, followed by HOMA-IR, MAP or TG/HDL-C.…”

Section: Discussionmentioning

confidence: 90%

“…Most studies have demonstrated that hyperleptinemia and hypoadiponectinemia are associated with the occurrence of T2DM, hypertension, dyslipidemia, MetS and CVD [7-14]. Moreover, some studies suggest that leptin/adiponectin ratio can be used as a potential atherogenic index [15] and provides adjunctive information for the risk of MetS [16]. However this has not been well studied in pediatric populations.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of metabolic syndrome in a cohort of Chinese schoolchildren: comparison of two definitions and assessment of adipokines as components by factor analysis

Wang

Yin

et al. 2013

BMC Public Health

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BackgroundAlthough attention to metabolic syndrome (MetS) in children has increased, there is still no universally accepted definition and its pathogenesis remains unclear. Our aim was to compare the current definitions of childhood MetS in a Chinese cohort and to examine the clustering pattern of MetS risk factors, particularly inclusion of leptin and adiponectin as additional components.Methods3373 schoolchildren aged 6 to 18 years were recruited. Anthropometric and biochemical parameters and adipokines were measured. MetS was identified using both the International Diabetes Federation (IDF) and a modified Adult Treatment Panel III (ATP III) definitions. Exploratory factor analysis was performed to establish grouping of metabolic characteristics.ResultsFor children ≥10 years, the prevalence of MetS was 14.3% in the obese group and 3.7% in the overweight group according to the new IDF definition, and 32.3% in the obese group and 8.4% in the overweight group according to the modified ATPIII definition. Frequency of hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), impaired fasting glucose, elevated blood pressure, and central obesity according to the new IDF definition was 16.7%, 20.7%, 15.8%, 25.5% and 75.5% in obese boys and 14.7%, 24.0%, 12.0%, 11.0% and 89.0% in obese girls, respectively. Metabolic abnormalities in children under 10 years of age were also noted. Using factor analysis on eight conventional variables led to the extraction of 3 factors. Waist circumference (WC) provided a connection between two factors in boys and all three factors in girls, suggesting its central role in the clustering of metabolic risk factors. Addition of leptin and adiponectin also led to the extraction of 3 factors, with leptin providing a connection between two factors in girls. When using WC, mean arterial pressure, triglyceride/HDL-C ratio, HOMA-IR and leptin/adiponectin ratio as variables, a single-factor model was extracted. WC had the biggest factor loading, followed by leptin/adiponectin ratio.ConclusionsMetS was highly prevalent amongst obese children and adolescents in this cohort, regardless of the definition used. Central obesity is the key player in the clustering of metabolic risk factors in children, supporting the new IDF definition. Moreover, our findings suggest that a common factor may underlie MetS. Leptin/adiponectin ratio as a possible component of MetS deserves further consideration.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Prevalence of metabolic syndrome in a cohort of Chinese schoolchildren: comparison of two definitions and assessment of adipokines as components by factor analysis

Wang

Yin

et al. 2013

BMC Public Health

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“…Plasma adiponectin—an anti-inflammatory hormone—is reversely correlated to BMI [31]. The leptin/adiponectin ratio is a marker of insulin resistance [32] and the metabolic syndrome [33]. Thus, both leptin and possibly eotaxin could contribute to relative eosinophilia in the obese.…”

Section: Discussionmentioning

confidence: 99%

Systemic Inflammation and Lung Function Impairment in Morbidly Obese Subjects with the Metabolic Syndrome

et al. 2013

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Background. Obesity and asthma are associated. There is a relationship between lung function impairment and the metabolic syndrome. Whether this relationship also exists in the morbidly obese patients is still unknown. Hypothesis. Low-grade systemic inflammation associated with the metabolic syndrome causes inflammation in the lungs and, hence, lung function impairment. Methods. This is cross-sectional study of morbidly obese patients undergoing preoperative screening for bariatric surgery. Metabolic syndrome was assessed according to the revised NCEP-ATP III criteria. Results. A total of 452 patients were included. Patients with the metabolic syndrome (n = 293) had significantly higher blood monocyte (mean 5.3 versus 4.9, P = 0.044) and eosinophil percentages (median 1.0 versus 0.8, P = 0.002), while the total leukocyte count did not differ between the groups. The FEV1/FVC ratio was significantly lower in patients with the metabolic syndrome (76.7% versus 78.2%, P = 0.032). Blood eosinophils were associated with FEV1/FVC ratio (adj. B −0.113, P = 0.018). Conclusion. Although the difference in FEV1/FVC ratio between the groups is relatively small, in this cross-sectional study, and its clinical relevance may be limited, these data indicate that the presence of the metabolic syndrome may influence lung function impairment, through the induction of relative eosinophilia.

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“…Although leptin has been documented to influence the development of cardiovascular risk factors, the association remains controversial and unclear . Recently, the leptin/adiponectin ratio has been used as an indicator of inflammatory states and metabolic syndromes, and the adiponectin/leptin ratio is an anti‐inflammatory marker in humans …”

Section: Introductionmentioning

confidence: 99%

The effect of weight loss magnitude on pro‐/anti‐inflammatory adipokines and carotid intima–media thickness in obese adolescents engaged in interdisciplinary weight loss therapy

Masquio

Piano

Sanches

et al. 2013

Clinical Endocrinology

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The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance: The Korean Genomic Rural Cohort Study

Cited by 39 publications

References 35 publications

Prevalence of metabolic syndrome in a cohort of Chinese schoolchildren: comparison of two definitions and assessment of adipokines as components by factor analysis

Prevalence of metabolic syndrome in a cohort of Chinese schoolchildren: comparison of two definitions and assessment of adipokines as components by factor analysis

Systemic Inflammation and Lung Function Impairment in Morbidly Obese Subjects with the Metabolic Syndrome

The effect of weight loss magnitude on pro‐/anti‐inflammatory adipokines and carotid intima–media thickness in obese adolescents engaged in interdisciplinary weight loss therapy

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