The ratios of pro-inflammatory to anti-inflammatory cytokines in the serum of chronic periodontitis patients with and without type 2 diabetes and/or smoking habit

Miranda, Tamires Szeremeske; Heluy, Sílvia Lacerda; Cruz, Daniele Ferreira; Silva, Hélio Doyle Pereira da; Feres, Magda; Figueiredo, Luciene Cristina; Duarte, Poliana Mendes

doi:10.1007/s00784-018-2471-5

Cited by 54 publications

(58 citation statements)

References 50 publications

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“…We detected IL-4, IL-6, IL-10, IL-17F, IL-33 and TNF-α; however, no statistically significant differences were found between the groups. Our data on IL-4, IL-6, IL-10 and TNF-α data are in line with several previously published papers [6,21,22], although significant differences in serum cytokines between healthy controls, aggressive and chronic periodontitis have been reported [6,[22][23][24].…”

Section: Discussionsupporting

confidence: 93%

“…A different study, however, reported no differences in the serum level of IL-1β between chronic periodontitis and healthy control groups [21]. Our data on IL-4, IL-6, IL-10 and TNF-α data are in line with several previously published papers [6,21,22], although significant differences in serum cytokines between healthy controls, aggressive and chronic periodontitis have been reported [6,[22][23][24]. We detected IL-4, IL-6, IL-10, IL-17F, IL-33 and TNF-α; however, no statistically significant differences were found between the groups.…”

Section: Discussionsupporting

confidence: 92%

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Comparative analysis of immune cell subsets in peripheral blood from patients with periodontal disease and healthy controls

Cheng

Saleh

Karim

et al. 2018

Clinical and Experimental Immunology

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Periodontitis is a chronic inflammatory disease caused by the colonization of teeth by the bacterial plaque biofilm and the resultant host immune responses in adjacent periodontal tissues. Disease severity can vary dramatically between patients with periodontitis, with some subjects displaying inflammation without bony destruction (gingivitis), while others experience chronic progressive or rapidly aggressive gingival connective tissue damage and bone loss. To determine whether peripheral immune dysregulation is associated with periodontitis, we performed extensive analysis of immune cell subsets in peripheral blood from patients with chronic or aggressive periodontitis versus periodontally healthy control subjects. Peripheral blood mononuclear cells (PBMC) from patients with chronic periodontitis or aggressive periodontitis and from periodontally healthy controls were analysed by 8-10-colour flow cytometry for the frequencies of various lymphocyte subsets, including interleukin (IL)-17-, interferon (IFN)-γ-, tumour necrosis factor (TNF)-α- and IL-10-producing cells, and the frequencies and phenotype of monocytes. Cytokine levels in serum from the different groups were determined by Luminex assay. We found no significant differences in the frequencies of major immune cell populations [CD4 T cells, CD8 T cells, γδ T cells, CD4 CD45RO CD25 CD127 regulatory T cells (T ), CD19 B cells, CD14 monocytes] or of cytokine-producing T cells, or in the phenotype of CD14 monocytes in peripheral blood from these patient cohorts. Additionally, no significant differences were observed in serum levels of prototypical inflammatory cytokines. These results suggest that the local gingival inflammatory response is not reflected by obvious changes in major blood immune cell subset frequencies.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Comparative analysis of immune cell subsets in peripheral blood from patients with periodontal disease and healthy controls

Cheng

Saleh

Karim

et al. 2018

Clinical and Experimental Immunology

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“…Lower concentration of IFN-γ could favor an uncontrolled infection or/and leading to more tissue damage. Added to this, IL-4 levels were lower in patients with slight PD when compared to controls, and this was consistent with previous studies [90,91]. Lower IL-4 levels were also found when PD patients had smoking habits and/or diabetes [91].…”

Section: Discussionsupporting

confidence: 92%

“…Added to this, IL-4 levels were lower in patients with slight PD when compared to controls, and this was consistent with previous studies [90,91]. Lower IL-4 levels were also found when PD patients had smoking habits and/or diabetes [91]. IL-4 produced at sites of infection can induce Th2 lymphocyte differentiation and activate antibody production by B cells and inhibit the Th1 response [92]; the Th2 response decreased bone loss in PD [93].…”

Section: Discussionsupporting

confidence: 89%

Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility

et al. 2020

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The pathogenesis of periodontitis (PD) involves several molecules of the immune system that interact in a network to eliminate the periodontopathogens, yet, they contribute to periodontal tissue destruction. The different mechanisms that lead to periodontal tissue damage are not clear. Despite this, immune response genes have been related to the development of PD previously, such as those involved in inflammasomes which are multiprotein complexes and cytokines including Interleukin-1. The aim of the study was to evaluate the polymorphisms in NLRP3 inflammasome, cytokine and receptor of cytokines genes in the development of periodontitis. This case-control study was conducted in 186 patients with PD (stage II and III and grade B) and 208 controls (localized gingivitis and periodontally healthy individuals). Genotyping was performed using PCR-RFLP for the SNP rs4612666 in NLRP3 and using PCR-SSP for IL1A,

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“…Another hallmark of the two diseases is dysregulation of the local (periarticular/periodontal) and systemic cytokine production, to a significant extent reflecting the aberrant immune response. Respective data have been presented in RA [12] and PD [13][14][15]. Particularly in RA, local and systemic cytokine profiling ultimately facilitated the introduction of new therapeutics, the biologics, which act in a more selective manner than conventional disease-modifying anti-rheumatic drugs (cDMARDs) such as methotrexate and leflunomide.…”

Section: Introductionmentioning

confidence: 99%

Association of cytokine patterns and clinical/laboratory parameters, medication and periodontal burden in patients with rheumatoid arthritis (RA)

et al. 2020

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To evaluate serum levels of the following cytokines in rheumatoid arthritis subjects with periodontal disease: Interleukin-6,-10,-17, and-23. Patients with rheumatoid arthritis frequently suffer from periodontal disease. Both diseases partly result from a dysregulated immune response. The current study aimed to quantify Interleukin-6,-10,-17, and-23 levels in rheumatoid arthritis. It should be investigated if the periodontal disease would have additional modifying effects. A total of 157 patients were included. Serum levels of IL-6,-10,-17, and-23 were measured by ELISA. Serum IL-10 increased with longer duration of morning stiffness and with higher rheumatoid factor and anti-cyclic citrullinated peptide titres. IL-10 was also elevated with longer duration of prednisolone (< 5 mg daily) and leflunomide therapy. Subjects with lower erythrocyte sedimentation rate/longer leflunomide therapy displayed more missing teeth/more clinical attachment loss. IL-17 was higher in subjects with fewer missing teeth if the following criteria were fulfilled: shorter prednisolone (< 5 mg) and methotrexate therapy, more swollen joints, longer morning stiffness. IL-23 finally was increased in subjects with higher rheumatoid factor and in those with higher periodontal probing depth/clinical attachment loss in the following situations: lower rheumatoid factor and shorter leflunomide therapy. Subjects suffering from dental/periodontal burden show an aberrant systemic cytokine availability of serum IL-6, IL-10, IL-17 and IL-23 related to disease activity and medication. This examination underlines the complexity of potential interactions between disease activity and medication related to periodontal burden.

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The ratios of pro-inflammatory to anti-inflammatory cytokines in the serum of chronic periodontitis patients with and without type 2 diabetes and/or smoking habit

Abstract: CP and CP associated with hyperglycemia and/or smoking might contribute to a systemic inflammatory burden and increased risk of systemic complications.

Cited by 54 publications

References 50 publications

Comparative analysis of immune cell subsets in peripheral blood from patients with periodontal disease and healthy controls

Comparative analysis of immune cell subsets in peripheral blood from patients with periodontal disease and healthy controls

Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility

Association of cytokine patterns and clinical/laboratory parameters, medication and periodontal burden in patients with rheumatoid arthritis (RA)

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