The regulation of ACC synthase protein turnover: a rapid route for modulating plant development and stress responses

Park, Chanung; Lee, Han Yong; Yoon, Gyeong Mee

doi:10.1016/j.pbi.2021.102046

Cited by 26 publications

(22 citation statements)

References 59 publications

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“…ACSs are involved in ETH biosynthesis via regulating their gene expression and phosphorylation‐mediated protein degradation (Park et al ., 2021). We found that MdSnRK2.9 interacted with MdACS1 (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Whether SnRK2-II and SnRK2-III are involved in regulating ETH biosynthesis requires further study. ETH controls the ripening of climacteric fruits (Chang, 2016;Park et al, 2021). Tomato fruit are a common model in ETHmediated ripening studies (Li et al, 2021;Park et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…ETH controls the ripening of climacteric fruits (Chang, 2016; Park et al ., 2021). Tomato fruit are a common model in ETH‐mediated ripening studies (Li et al ., 2021; Park et al ., 2021). Recently, our understanding of the transcriptional regulation of ETH‐mediated fruit ripening has improved (Barry et al ., 2000; Alexander & Grierson, 2002; Cara et al ., 2008; Gapper et al ., 2013; Kou et al ., 2016; Li et al ., 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Ethylene (ETH) is an important hormone involved in the regulation of plant growth, fruit ripening, and stress responses (Gane, 1934; Chang, 2016; Park et al ., 2021). Fruits are classified as climacteric and nonclimacteric based on whether or not ETH controls ripening (Adams‐Phillips et al ., 2004).…”

Section: Introductionmentioning

confidence: 99%

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SnRK2 subfamily I protein kinases regulate ethylene biosynthesis by phosphorylating HB transcription factors to induce ACO1 expression in apple

Jia

Wang

et al. 2022

New Phytologist

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Ethylene (ETH) controls climacteric fruit ripening and can be triggered by osmotic stress. However, the mechanism regulating ETH biosynthesis during fruit ripening and under osmotic stress is largely unknown in apple (Malus domestica).Here, we explored the roles of SnRK2 protein kinases in ETH biosynthesis related to fruit ripening and osmoregulation. We identified the substrates of MdSnRK2-I using phosphorylation analysis techniques. Finally, we identified the MdSnRK2-I-mediated signaling pathway for ETH biosynthesis related to fruit ripening and osmoregulation.The activity of two MdSnRK2-I members, MdSnRK2.4 and MdSnRK2.9, was significantly upregulated during ripening or following mannitol treatment. Overexpression of MdSnRK2-I increased ETH biosynthesis under normal and osmotic conditions in apple fruit. MdSnRK2-I phosphorylated the transcription factors MdHB1 and MdHB2 to enhance their protein stability and transcriptional activity on MdACO1. MdSnRK2-I also interacted with MdACS1 and increased its protein stability through two phosphorylation sites. The increased MdACO1 expression and MdACS1 protein stability resulted in higher ETH production in apple fruit. In addition, heterologous expression of MdSnRK2-I or manipulation of SlSnRK2-I expression in tomato (Solanum lycopersicum) fruit altered fruit ripening and ETH biosynthesis.We established that MdSnRK2-I functions in fruit ripening and osmoregulation, and identified the MdSnRK2-I-mediated signaling pathway controlling ETH biosynthesis.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

SnRK2 subfamily I protein kinases regulate ethylene biosynthesis by phosphorylating HB transcription factors to induce ACO1 expression in apple

Jia

Wang

et al. 2022

New Phytologist

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“…SAM is then converted to 1-aminocyclopropane-1-carboxylic acid (ACC) and methylthioadenosine (MTA), by 1-aminocyclopropane-1-carboxylate synthase (ACS). ACC can be oxidized by ACC oxidases (ACO) to produce ET (Park et al, 2021). Because SAM acts as a precursor of ET and polyamines, SAMS is important for ET production.…”

Section: Introductionmentioning

confidence: 99%

A Peronophythora litchii RXLR effector PlAvh202 enhances plant susceptibility by destabilizing host SAMS

Zhou

Situ

et al. 2022

Preprint

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Oomycete pathogens can secret hundreds of effectors into plant cells to interfere with plant immune system during infection. Here we identified a cytoplasmic RXLR effector from the most destructive pathogen of litchi, Peronophythora litchii, and named it as PlAvh202. PlAvh202 could suppress cell death triggered by INF1 and Avr3a/R3a in Nicotiana benthamiana, and was essential for P. litchii virulence. In addition, PlAvh202 also suppressed plant immune responses and promoted the susceptibility of N. benthamiana to Phytophthora capsici. Further research revealed that PlAvh202 could suppress ethylene (ET) production by targeting and destabilizing plant S-adenosyl-L-methionine synthetase (SAMS), a key enzyme in ET biosynthesis pathway, in a 26S proteasome-dependent manner. Transient expression of LcSAMS3 induced ET production and enhanced plant resistance, whereas inhibition of ET biosynthesis promoted P. litchii infection, supporting that LcSAMS and ET positively regulate litchi immunity towards P. litchii. Overall, these findings highlight that SAMS can be targeted by oomycete RXLR effector to manipulate ET-mediated plant immunity.

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Molecular and genetic characterization of ethylene insensitive mutants in snapdragon

Heffron

Korban

2022

Plant Growth Regul

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The regulation of ACC synthase protein turnover: a rapid route for modulating plant development and stress responses

Cited by 26 publications

References 59 publications

SnRK2 subfamily I protein kinases regulate ethylene biosynthesis by phosphorylating HB transcription factors to induce ACO1 expression in apple

SnRK2 subfamily I protein kinases regulate ethylene biosynthesis by phosphorylating HB transcription factors to induce ACO1 expression in apple

A Peronophythora litchii RXLR effector PlAvh202 enhances plant susceptibility by destabilizing host SAMS

Molecular and genetic characterization of ethylene insensitive mutants in snapdragon

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