The relation between neutrophil–lymphocyte ratio and acute kidney injury

Balta, Şevket; Uslu, Ali Uğur; Ünlü, Murat; Demırkol, Sait; Öztürk, Cengiz

doi:10.3109/0886022x.2015.1077311

Cited by 3 publications

(2 citation statements)

References 12 publications

(13 reference statements)

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“…It can be caused either by heart infection (such as infectious endocarditis) or other chronic infectious diseases (COPD). In clinical practice, the neutrophil to lymphocyte ratio (NLR) is an easily effective and low-cost biomarker of inflammatory status [5,6]. Previous studies have demonstrated its value in early prediction of infectious conditions [5,7], cancers [8][9][10][11][12][13] and cardiovascular diseases [14].…”

Section: Introductionmentioning

confidence: 99%

Dynamics in perioperative neutrophil-to-lymphocyte*platelet ratio as a predictor of early acute kidney injury following cardiovascular surgery

Zou

Zhang

et al. 2021

Renal Failure

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Background: In this study, we applied a composite index of neutrophil-lymphocyte Ã platelet ratio (NLPR), and explore the significance of the dynamics of perioperative NLPR in predicting cardiac surgery-associated acute kidney injury (CSA-AKI). Methods: During July 1 st and December 31 th 2019, participants were prospectively derived from the 'Zhongshan Cardiovascular Surgery Cohort'. NLPR was determined using neutrophil counts, lymphocyte and platelet count at the two-time points. Dose-response relationship analyses were applied to delineate the non-linear odds ratio (OR) of CSA-AKI in different NLPR levels. Then NLPRs were integrated into the generalized estimating equation (GEE) to predict the risk of AKI. Results: Of 2449 patients receiving cardiovascular surgery, 838 (34.2%) cases developed CSA-AKI with stage 1 (n ¼ 658, 26.9%), stage 2-3 (n ¼ 180, 7.3%). Compared with non-AKI patients, both preoperative and postoperative NLPR were higher in AKI patients (1.

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Section: Introductionmentioning

confidence: 99%

Dynamics in perioperative neutrophil-to-lymphocyte*platelet ratio as a predictor of early acute kidney injury following cardiovascular surgery

Zou

Zhang

et al. 2021

Renal Failure

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“…In our study, we also found significant results for CRP, platelet, WBC and neutrophil values in addition to NLR when cases with AKI were compared to the non-AKI group [32]. In their letter to editor, Balta et al criticized some aspects of the study by Yılmaz et al Balta et al stated that NLR could not be a predictor in cases with AKI, because NLR can be affected by many factors including the methods used for phlebotomy, and NLR could be lower in patients receiving statin treatment and antihypertensive treatment (valsartan, nebivolol, amlodipin), and they stated that the results reported by Yılmaz et al [31] were not reliable, and that these results should be supported with other serum inflammation markers [33]. In our opinion, the critical reviews put forward by Balta et al are not justifiable.…”

Section: Discussionmentioning

confidence: 74%

Can Blood Groups, Neutrophil-Lymphocyte Ratio and Mean Platelet Volume Predict Mortality in Critically Ill Patients Developing Acute Kidney Injury?

Çanakçı

2017

JACCOA

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Utility and Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Dogs with Septic Peritonitis

Hodgson

Todd

Schaeffer

2018

Journal of the American Animal Hospital Association

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Systemic inflammation is known to cause WBC abnormalities, specifically neutrophilia and lymphopenia. The neutrophil-to-lymphocyte ratio (NLR) is a simple and affordable biomarker that has been used in human clinical settings of sepsis but has not been investigated in veterinary species. We evaluated NLR in dogs with septic and nonseptic systemic inflammatory diseases and compared with a healthy dog population. An NLR ≥6 had an 84.39% sensitivity and 86.95% specificity to identify dogs with systemic inflammatory states; however, no ratio distinguished septic and nonseptic causes. The NLR was not associated with length of hospitalization, morbidity based on the acute patient physiologic laboratory evaluation scoring system, or mortality. The disassociation may be due to the retrospective nature of the study, including a restricted population size and acquisition of only a one-time blood sample. NLR is currently of limited use for diagnosis and prognosis in systemic inflammatory states in dogs, and larger, prospective studies are necessary to further evaluate NLR.

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The relation between neutrophil–lymphocyte ratio and acute kidney injury

Cited by 3 publications

References 12 publications

Dynamics in perioperative neutrophil-to-lymphocyte*platelet ratio as a predictor of early acute kidney injury following cardiovascular surgery

Dynamics in perioperative neutrophil-to-lymphocyte*platelet ratio as a predictor of early acute kidney injury following cardiovascular surgery

Can Blood Groups, Neutrophil-Lymphocyte Ratio and Mean Platelet Volume Predict Mortality in Critically Ill Patients Developing Acute Kidney Injury?

Utility and Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Dogs with Septic Peritonitis

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