The relation between sphingomyelinase activity, lipid peroxide oxidation and NO‐releasing in mice liver and brain

Alessenko, A. V.; Shupik, M. A.; Gutner, U. A.; Бугрова, А. Е.; Dudnik, L. B.; Shingarova, L. N.; Mikoyan, A.; Vanin, A. F.

doi:10.1016/j.febslet.2005.08.085

Cited by 19 publications

(10 citation statements)

References 43 publications

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“…Exercise training has been shown to reduce plasma inflammatory markers including tumor necrosis factor[78], a key inducer of ceramide synthesis[86]. Reduced inflammatory signaling with exercise has been associated with decreased de novo synthesis of ceramides[87].…”

Section: Discussionmentioning

confidence: 99%

A Lipidomics Approach to Assess the Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for Cognitive Response to Exercise

Saleem

Herrmann

Dinoff

et al. 2017

JAD

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Background Early subtle deficits in verbal memory, which may indicate early neural risk, are common in patients with coronary artery disease (CAD). While exercise can improve cognition, cognitive response to exercise is heterogeneous. Sphingolipids have been associated with the development and progression of CAD, and impairments in sphingolipid metabolism may play roles in neurodegeneration, and in the neural adaptation response to exercise. In this study, change in plasma concentrations of sphingolipids were assessed in relation to change in verbal memory performance and in other cognitive domains among CAD subjects undertaking a 6-month cardiac rehabilitation (CR) program. Methods Patients with CAD (n=120, mean age=64±6 years, 84% male, years of education=16±3 years) underwent CR with neuropsychological assessments and blood collected at baseline, 3-, and 6-months. Z-scores based on age, gender and education were combined for verbal memory, visuospatial memory, processing speed, executive function and global cognition tasks to calculate cognitive domain Z-scores. Plasma sphingolipid concentrations were measured from fasting blood samples using high performance liquid chromatography coupled electrospray ionization tandem mass spectrometry (LC/MS/MS). Mixed models were used to identify sphingolipids significantly associated with performance in verbal memory and other cognitive domains, adjusting for potential confounders. Results A decrease in ceramide C18:0 concentrations was significantly associated with improvement in verbal memory performance (b[SE]=-0.51 [0.25], p=0.04), visuospatial memory (b[SE]=-0.44 [0.22], p=0.05), processing speed (b[SE]=-0.89 [0.32], p=0.007) and global cognition (b[SE]=-1.47 [0.59], p=0.01) over 6 months of CR. Conclusions Plasma ceramide C18:0 concentrations may be a sensitive marker of cognitive response to exercise in patients with CAD.

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Section: Discussionmentioning

confidence: 99%

A Lipidomics Approach to Assess the Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for Cognitive Response to Exercise

Saleem

Herrmann

Dinoff

et al. 2017

JAD

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“…In addition to iron-induced lipid peroxidation, iron can also promote sphingomyelin breakdown via activation of sphingomyelinases, generating the product ceramide (which is involved in mediating the regulated cell death response) [101] that then contributes to neuronal apoptosis, a feature of neurodegenerative diseases. In support, increased levels of sphingomyelin coinciding with reduced ceramide content is associated with neuronal protection and may thus be a targetable pathway (using iron chelators) for treatment [102].…”

Section: Iron and Lipids: Neurodegenerative Diseasesmentioning

confidence: 99%

Links Between Iron and Lipids: Implications in Some Major Human Diseases

et al. 2018

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Maintenance of iron homeostasis is critical to cellular health as both its excess and insufficiency are detrimental. Likewise, lipids, which are essential components of cellular membranes and signaling mediators, must also be tightly regulated to hinder disease progression. Recent research, using a myriad of model organisms, as well as data from clinical studies, has revealed links between these two metabolic pathways, but the mechanisms behind these interactions and the role these have in the progression of human diseases remains unclear. In this review, we summarize literature describing cross-talk between iron and lipid pathways, including alterations in cholesterol, sphingolipid, and lipid droplet metabolism in response to changes in iron levels. We discuss human diseases correlating with both iron and lipid alterations, including neurodegenerative disorders, and the available evidence regarding the potential mechanisms underlying how iron may promote disease pathogenesis. Finally, we review research regarding iron reduction techniques and their therapeutic potential in treating patients with these debilitating conditions. We propose that iron-mediated alterations in lipid metabolic pathways are involved in the progression of these diseases, but further research is direly needed to elucidate the mechanisms involved.

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“…The process is realized at least via two mechanisms: (a) inactivation of caspases due to oxidation of their active site thiol groups; b) critical decrease of intracellular ATP con centrations due to oxidative damage of mitochondria. It is known that administration of TNF α to rats increased LPO content and nSMase activity in the brain and liver [25]. Taking into consideration these data and also lack of unified classification of severity of oxidative stress, we suggest that under our experimen tal conditions increased serum concentrations of TNF α and hepatic CD and TBARS (Table 4) may promote activation of the key enzyme of the SM cycle observed by day 3 of starvation.…”

Section: Resultsmentioning

confidence: 79%

A functional state of the sphingomyelin cycle and activity of free radical oxidation of rat liver lipids at different phases of starvation

Kuzmenko

Burov

Serebrov

et al. 2011

Biochem. Moscow Suppl. Ser. B

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A functional state of the sphingomyeline cycle and its links with processes of free radical lipid oxi dation have been investigated in rat liver during starvation of animals without any restriction of access to drinking water at day 1, 2, 3 (phase I) and day 6 (phase II of starvation). The maximal values of the ceram ide/sphingomyelin ratio and activities of neutral sphingomyelinase and executive caspase 3 were found in rat livers at day 3 of starvation. Since day 3 of starvation an increase of tumour necrosis factor α, one of neutral sphingomyelinase activators, was detected in serum. During the major part of phase I of starvation the inten sity of liver free radical lipid peroxidation was comparable to that of control due to competent functioning of the antioxidant defense system. Transition of phase I to phase II of starvation (day 6 of the experiment) was accompanied by the development of oxidative stress associated with depletion of the antioxidant defense sys tem. The results obtained in this study suggest that phase I of starvation favors realization of the ceramide mediated proapoptotic signaling in the liver. In our viewpoint, ceramide mediated apoptosis is one of mech anisms used optimization of liver cellular population within the frame of metabolic adaptation. In rat liver phase I of starvation was characterized by prevailing of the ceramide mediated proapoptotic signaling, while in phase II oxidative stress dominated.

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The relation between sphingomyelinase activity, lipid peroxide oxidation and NO‐releasing in mice liver and brain

Cited by 19 publications

References 43 publications

A Lipidomics Approach to Assess the Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for Cognitive Response to Exercise

A Lipidomics Approach to Assess the Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for Cognitive Response to Exercise

Links Between Iron and Lipids: Implications in Some Major Human Diseases

A functional state of the sphingomyelin cycle and activity of free radical oxidation of rat liver lipids at different phases of starvation

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