The relation of serum nesfatin-1 level with metabolic and clinical parameters in obese and healthy children

Abacı, Ayhan; Çatlı, Gönül; Anık, Ahmet; Küme, Tuncay; Böber, Ece

doi:10.1111/pedi.12009

Cited by 51 publications

(53 citation statements)

References 39 publications

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“…A strong correlation has been reported between N1 and pro-inflammatory cytokines [32,33]. There are studies reporting the association between the low N1 levels and the elevated systolic and diastolic BP [34]. Although basal N1 levels have an anti-inflammatory effect, its low-level increases inflammation, possibly leading to the development of hypertension.…”

Section: Discussionmentioning

confidence: 98%

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Şahin

Ural

et al. 2015

Biomol Biomed

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Polycystic ovary syndrome (PCOS) is one of the most common causes of female infertility. It affects nearly 5-10% of young women. It is characterized by the presence of hirsutism, acne, anovulation, hyperandrogenism, polycystic ovaries, and infertility [1]. Many mechanisms have been reported to be responsible for the pathophysiology of PCOS. The condition is thought to be determined by complex interactions between the hypothalamic-pituitary-ovarian or hypothalamic-pituitary-adrenal axis functions and metabolic disorders, such as obesity, insulin resistance (IR), and compensatory hyperinsulinemia [2]. PCOS increases the prevalence of hyperglycemia, hypertension, and dyslipidemia [3], increasing thus the risk of developing cardiovascular diseases [4].Nesfatin-1 (N1) is derived from nucleobindin 2 (NUCB2), which is encoded by the NUCB2 gene. It is a newly identified peptide that has 82 amino acids [5]. It is released from several tissues including forebrain, hindbrain, brainstem, spinal cord, adipose tissues [6]. It has an anorexigenic effect and plays an important role in hypothalamic pathways such as regulating food intake, energy homeostasis, water intake, and body temperature [7,8]. In addition, it exerts cardiovascular and hypertensive effects [9]. It is closely related to glucose, insulin metabolism, and IR [5,10]. Several studies have demonstrated N1 to be associated with body mass index (BMI), IR, inflammatory stimulation in diabetes, hypertension, and PCOS [9][10][11]. It may also affect the control of the reproduction system, e.g. puberty onset and gonadotropin secretion [12]. ABSTRACTObesity, insulin resistance (IR), inflammation, and hyperandrogenism may lead to polycystic ovary syndrome (PCOS) and hypertension. Nesfatin-1 (N1) may be related to IR, obesity, and hypertension. Furthermore, a vitamin D (VD) deficiency is associated with hypertension and PCOS. We aimed to investigate N1 and VD levels in PCOS that have an effect on systolic and diastolic blood pressure (BP) and heart rate (HR). This study included 54 patients with PCOS and 48 age-body mass index (BMI)-matched healthy controls. PCOS was diagnosed according to clinical practice guidelines. Ferriman-Gallwey scores (FGS) were calculated, while N1, VD, and other hormonal and biochemical parameters were measured for all subjects. Systolic and diastolic BP was measured as well. HR was calculated using an electrocardiogram. The levels of N1 (p < 0.001), high-sensitivity C-reactive protein (hs-CRP) (p = 0.036), homeostasis model assessment as an index of insulin resistance (HOMA-IR) (p < 0.001), systolic (p < 0.001) and diastolic (p < 0.001) BP and HR (p < 0.001) in the PCOS group were significantly higher than in the control group. However, the VD levels of the PCOS group were lower than the control group (p = 0.004). N1 had a strong positive correlation with BMI, HOMA-IR, hs-CRP, luteinizing hormone, systolic and diastolic BP, and HR. VD levels were negatively correlated with HOMA-IR and luteinizing hormone. Elevated N1 and decreased VD levels may...

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Section: Discussionmentioning

confidence: 98%

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Şahin

Ural

et al. 2015

Biomol Biomed

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“…In addition, in obese subjects nesfatin-1 was negatively correlated with the BMI. 15 Moreover, Tsuchiya et al reported that fasting nesfatin-1 level was significantly lower in subjects with high BMI than in non-obese subjects, and the peripheral concentration of nesfatin-1 showed a negative correlation with BMI, percentage of body fat, body fat weight and blood glucose. 5 In patients with nonalcoholic fatty liver disease, serum nesfatin-1 level in the obese group was significantly lower than in the non-obese group.…”

Section: Discussionmentioning

confidence: 99%

Plasma Nesfatin-1 Level in Obese Patients after Acupuncture: A Randomised Controlled Trial

et al. 2014

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Background Nesfatin-1 is an anorexigenic hormone suggested to regulate obesity. Objective To investigate the relationship between nesfatin-1 level and anthropometric and metabolic parameters in obese patients, and examine the change in plasma nesfatin-1 level after acupuncture treatment. Methods 64 obese adult patients without diabetes and 58 normal weight control subjects were enrolled in this study. The obese patients were randomly divided into an acupuncture plus diet group (n=32) and a diet only group (n=32). Measurements were repeated after 45 days. Results Body mass index (BMI), waist and hip circumferences, serum insulin, lipoprotein and insulin resistance measures were significantly higher, and plasma nesfatin-1 level was significantly lower, in obese patients than in normal weight controls. In addition, negative correlations were found between plasma nesfatin-1 level and BMI, waist and hip circumferences. Weight reduction in participants after acupuncture and diet restriction was 7.0% and 4.3%, respectively. Plasma nesfatin-1 level increased from 2.75±1.16 to 3.44±1.28 ng/mL and from 2.86±1.07 to 3.23±1.06 ng/mL in acupuncture and diet groups, respectively; the difference was significant, p<0.05. Conclusions Plasma nesfatin-1 level is reduced in obese adults, and is increased after acupuncture. The beneficial effect of acupuncture on obesity is associated with increased plasma nesfatin-1 level.

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“…Kaba et al (12) found no significant association between BMI SDS and nesfatin-1 (neither in underweight children nor in control groups), while Kahraman et al (13) demonstrated a positive correlation between BMI SDS and nesfatin-1. Similarly, conflicting results regarding the nesfatin-1 level were observed in studies performed in obese children (32)(33)(34). Abaci et al (32) previously reported lower serum nesfatin-1 levels in obese subjects compared to those of healthy controls and a negative correlation between nesfatin-1 and BMI in nonobese males.…”

Section: Discussionmentioning

confidence: 98%

“…Similarly, conflicting results regarding the nesfatin-1 level were observed in studies performed in obese children (32)(33)(34). Abaci et al (32) previously reported lower serum nesfatin-1 levels in obese subjects compared to those of healthy controls and a negative correlation between nesfatin-1 and BMI in nonobese males. In addition, it has been speculated that low levels of this satiety peptide may be one of the reasons for inadequately controlled food intake.…”

Section: Discussionmentioning

confidence: 98%

Increased concentrations of serum nesfatin-1 levels in childhood with idiopathic chronic malnutrition

Acar¹,

Çatlı²,

Küme³

et al. 2018

Turk J Med Sci

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Background/aim: Nesfatin-1, an anorexigenic molecule, seems to play a role in appetite regulation and energy homeostasis. The goal of this study was to evaluate the relation of nesfatin-1 with anthropometric and metabolic (ghrelin, leptin) parameters in children with idiopathic chronic malnutrition. Materials and methods:The study included 37 underweight and 38 healthy children who were similar regarding age, sex, and pubertal status. Anthropometric and biochemical (nesfatin-1, ghrelin, and leptin levels) variables were assessed.Results: A total of 37 underweight subjects (mean age 10.5 ± 2.6 years) and 38 heathy subjects (mean age 10.3 ± 2.3 years) were recruited. Underweight children had significantly higher nesfatin-1 (2.76 ± 0.4 vs. 1.56 ± 0.7, P < 0.001) and lower leptin levels (2.21 ± 2.0 vs. 5.21 ± 2.4, P < 0.001) than those of the control subjects. Nesfatin-1 levels were significantly associated with only leptin levels, after adjusting for age and BMI (r = -0.371, P = 0.001). Conclusion:The present study is the first to evaluate nesfatin-1 levels in relation with anthropometric and metabolic parameters in children with chronic malnutrition, who were subsequently found to have significantly higher nesfatin-1 levels. Our study underlines that nesfatin-1 may play a role in the development of malnutrition by inhibiting food intake in children.

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The relation of serum nesfatin-1 level with metabolic and clinical parameters in obese and healthy children

Cited by 51 publications

References 39 publications

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Plasma Nesfatin-1 Level in Obese Patients after Acupuncture: A Randomised Controlled Trial

Increased concentrations of serum nesfatin-1 levels in childhood with idiopathic chronic malnutrition

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