The Relationship between Age and Pleural Fluid Adenosine Deaminase Activity in Pleural Tuberculosis

Moon, Jin Wook; Han, Chang Hoon; Kang, Shin Myung; Park, Moo Suk; Hwang, Sang Yeon; Byun, Min Kwang; Chung, Wou Young; Hwang, Hye Jin; Kim, Young Sam; Kim, Se Kyu; Chang, Joon; Kim, Sung Kyu

doi:10.4046/trd.2005.58.5.459

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…As an indicator of cellular immunity, the serum activity of this enzyme has been suggested to be altered in diseases that cause a cell-mediated immune response such as rheumatoid arthritis, systemic lupus erythematosus, and tuberculosis (2, 3). …”

Section: Introductionmentioning

confidence: 99%

“…Adenosine deaminase (ADA), an enzyme essential for the differentiation of lymphoid cells, has been used for monitoring several diseases in which immunity has been altered ( 1 ). As an indicator of cellular immunity, the serum activity of this enzyme has been suggested to be altered in diseases that cause a cell-mediated immune response such as rheumatoid arthritis, systemic lupus erythematosus, and tuberculosis ( 2 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

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Changes in Serum Adenosine Deaminase Activity during Normal Pregnancy

et al. 2007

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Adenosine deaminase (ADA), an enzyme essential for the differentiation of lymphoid cells, has been used for monitoring diseases with altered immunity. The purpose of this study was to investigate the changes in serum ADA activity throughout normal pregnancy. We measured the catalytic values of serum ADA from 202 normal pregnant women using a commercial kit. Subjects were divided into four groups according to the gestational age in weeks (Gwks) (Group I: 5-9 Gwks [n=58]; Group II: 15-20 Gwks [n= 63]; Group III: 24-30 Gwks [n=34]; Group IV: 30-39 Gwks [n=47]). The serum ADA levels for the Groups I, II, III, and IV were as follows: 20.1±6.9 IU/L, 20.0±7.6 IU/L, 37.9±19.9 IU/L, and 24.5±8.6 IU/L, respectively. The serum ADA activity of group III was significantly higher than the other groups (p<0.05). However, there was no significant correlation between the Gwks and the serum ADA activity. Furthermore, other parameters, such as maternal age (p=0.29), gestational age at delivery (p=0.07), delivery mode (p=0.39), and birth weight (p=0.59) had no correlation with ADA activity. Reference values of serum ADA in normal pregnancy may provide important database for making clinical decisions in pregnancies complicated by conditions where cellular immunity has been altered.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in Serum Adenosine Deaminase Activity during Normal Pregnancy

et al. 2007

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“…The changes of the serum level of ADA has been expected in some rheumatologic disorders such as juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE), and Henoch-Schonlein purpura (HSP) in which cell-mediated immunity has been altered [2][3]. Multiple organ involvement is a common characteristic of these rheumatic disorders.…”

Section: Introductionmentioning

confidence: 99%

“…Serum ADA activity has closely relation with active lupus disease activity and it can be used as diagnostic factor [3,7]. There is a few study on ADA in JIA patients and it is suggested serum ADA is increased in chronic inflammatory arthritis [2,8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Adenosine Deaminase Changes Before and After Treatment in Patients with Systemic Lupus Erythematosus, Henoch-Schonlein Purpura and Juvenile Idiopathic Arthritis

Ziaee

Amiran²,

Moradinejad³

et al. 2013

Ann Paediatr Rheum

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Background: Adenosine deaminase (ADA) is a purine metabolism enzyme that can be used as an indicator of cellular immunity for monitoring of inflammatory diseases. The aim of this study was to investigate the changes of serum adenosine deaminase before and after treatment in patients with systemic lupus erythematosus (SLE), Henoch-Schonlein purpura (HSP) and juvenile idiopathic Arthritis (JIA). Methods: The study comprised 103 patients with JIA, 17 with SLE and 30 HSP. The serum ADA was measured of all patients before and after treatment or remission. Serum ADA was measured by an ultraviolet kinetic method with NADH as substrate. Normal value for serum ADA level was less than 15 IU/L. Results: Positive serum ADA was found in 38 patients with JIA (38.9%), 9 patients (52.9%) with SLE and 6 patients (20%) with HSP. During the disease activity (before treatment), the mean serum ADA in patients with JRA was 15.1±10.9 IU/l, vs. 12.6±4.5 IU/l in patients with HSP and 18.8±11.95 IU/l in patients with SLE (P=0.097). There was no significant differences in changes of ADA levels between disease activity and after control (p= 0.1) in SLE. In patients with JIA, there was significant differences in changes of ADA levels between disease activity and control (p= 0.01). There was no significant differences in changes of ADA levels between disease activity and control (p= 0.2) in HSP. Conclusion: Determination of ADA serum levels is as noninvasive method, reliable and easy for diagnosis of JIA and can be used as alternative parameters representing disease activity in SLE patients.

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Adenosine deaminase activity in normal pregnancy and pregnancy associated disorders

Jadhav

Jain

2013

Archives of Physiology and Biochemistry

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Adenosine deaminase (ADA) is an enzyme of purine salvage pathway and has two important isoenzymes ADA1 and ADA2. The activity of ADA has been changed in diseases characterized by altered cell-mediated immunity. It was observed that total serum ADA activity was decreased during normal pregnancy compared with non-pregnant women. However, total serum ADA activity and serum ADA2 activity was increased in hyperemesis gravidarum and pre-eclampsia in pregnant women. Less information is available regarding role of ADA in abortions (recurrent and missed) and anembryonic pregnancies. Here, we review the activity of ADA and its isoenzymes. Despite these findings, it will be interesting to know whether activity of ADA will be same if ADA is estimated throughout the pregnancy and in pregnancy related complications from early first trimester to third trimester, as all studies until now were carried out at a particular stage of pregnancy.

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The Relationship between Age and Pleural Fluid Adenosine Deaminase Activity in Pleural Tuberculosis

Cited by 5 publications

References 21 publications

Changes in Serum Adenosine Deaminase Activity during Normal Pregnancy

Changes in Serum Adenosine Deaminase Activity during Normal Pregnancy

Evaluation of Serum Adenosine Deaminase Changes Before and After Treatment in Patients with Systemic Lupus Erythematosus, Henoch-Schonlein Purpura and Juvenile Idiopathic Arthritis

Adenosine deaminase activity in normal pregnancy and pregnancy associated disorders

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