The relationship between age and carotid artery intima-media thickness, hemoglobin A1c in nondiabetic, healthy geriatric population

Doruk, Hüseyin; Mas, Mehmet Refik; Ateskan, Umit; Işık, Ahmet Turan; Sağlam, Mutlu; Kutlu, Mustafa

doi:10.1016/j.archger.2004.11.004

Cited by 15 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1) is in agreement with earlier reports [22][23][24] as to the absence of a significant correlation between HbA1c and age [25]. The results of this study clearly showed that the levels of HbA1c and FBG are not affected by patients' gender as neither of these parameters differed significantly between male and female diabetic patients (Table 1).…”

Section: Discussionsupporting

confidence: 95%

Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia

2007

View full text Add to dashboard Cite

Impaired lipid metabolism resulting from uncontrolled hyperglycaemia has been implicated in cardiovascular complications in diabetes patients. The aim of this study was to examine the impact of glycaemic control on the lipid profile of diabetic patients. We also determined the ability of glycated haemoglobin (HbA(1c)) as an indirect marker of dyslipidaemia. A total of 1011 type 2 diabetic patients (males, 574; females, 437; mean age, 59.76 years) were included in this study. Venous blood samples were collected from all the subjects after at least 8 h fasting. The sera were analysed for HbA(1c), fasting blood glucose (FBG), total cholesterol, triglycerides (TG), high-density lipoprotein cholesterol (HDL) and low-density lipoprotein cholesterol (LDL). The levels of HbA(1c), FBG and LDL did not differ significantly between males and females. Female patients showed significantly higher serum cholesterol and HDL but significantly lower TG levels as compared to males. There was a highly significant correlation between HbA(1c) and FBG. Both HbA(1c) and FBG exhibited direct correlations with cholesterol, TG and LDL and inverse correlation with HDL; the magnitude of significance for all these lipid parameters being greater with HbA(1c) than FBG. There was a linear relationship between HbA(1c) and dyslipidaemia. The levels of serum cholesterol and TG were significantly higher and of HDL significantly lower in patients with worse glycaemic control as compared to patients with good glycaemic control. The findings of this study clearly indicate that HbA(1c) is not only a useful biomarker of long-term glycaemic control but also a good predictor of lipid profile. Thus, monitoring of glycaemic control using HbA(1c) could have additional benefits of identifying diabetic patients who are at a greater risk of cardiovascular complications.

show abstract

Section: Discussionsupporting

confidence: 95%

Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia

2007

View full text Add to dashboard Cite

show abstract

“…This result is different from a previous research in a nondiabetic healthy geriatric population, where no relationship between carotid IMT and age was identified [21]. On the other hand, some studies found a correlation between carotid IMT and age both in adult and geriatric nondiabetic populations [22,23].…”

Section: Discussioncontrasting

confidence: 93%

Insulin resistance and adipokine levels correlate with early atherosclerosis – a study in prediabetic patients

et al. 2014

View full text Add to dashboard Cite

Cardiovascular risk of prediabetes is still subject to controversies. We analyzed the associations between insulin resistance, adipokines and incipient atherosclerosis estimated by intima-media thickness (IMT) in a cross-sectional study on 122 prediabetic subjects without clinical signs of atherosclerotic disease. Homeostasis model assessment of insulin resistance (HOMA-IR, calculated as fasting insulin × fasting plasma glucose / 22.5), adiponectin, leptin, leptin-to-adiponectin ratio, carotid and femoral IMT were evaluated. We also assessed other parameters related to insulin resistance and adipokines (HbA1c, anthropometric and lipid parameters), as they may also influence atherosclerosis. Carotid IMT was correlated to adiponectin and leptin-to-adiponectin ratio (all p < 0.05), but not with HOMA-IR or leptin, while femoral IMT showed no relationship with these factors. After adjusting for leptin, leptin-to-adiponectin ratio, triglycerides, HDL-cholesterol, cholesterol-to-HDL ratio, triglycerides-to-HDL ratio and HbA1c, IMT values became correlated with HOMA-IR. Adjustment for HOMA-IR induced the appearance of new correlations between adipokines and both IMT values. In conclusion, insulin resistance and adipokines seem related to IMT in prediabetic subjects without clinical signs of arterial obstruction.

show abstract

“…Our study found a borderline association between carotid IMT and glycated hemoglobin. Previous studies have examined this relationship in nondiabetic [28] and in diabetic patients [10,13,29], some with positive [13,28] but others with negative findings [10,29]. This issue is important because of the possibility that an improvement in glucose control could be able to reduce the progression of carotid IMT [29] and, hence, the progression of atherosclerotic process.…”

Section: Discussionmentioning

confidence: 95%

Factors associated with carotid intima-media thickness and carotid plaques in type 2 diabetic patients

Cardoso¹,

Marques

Leite³

et al. 2012

Journal of Hypertension

View full text Add to dashboard Cite

show abstract

The relationship between age and carotid artery intima-media thickness, hemoglobin A1c in nondiabetic, healthy geriatric population

Cited by 15 publications

References 33 publications

Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia

Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia

Insulin resistance and adipokine levels correlate with early atherosclerosis – a study in prediabetic patients

Factors associated with carotid intima-media thickness and carotid plaques in type 2 diabetic patients

Contact Info

Product

Resources

About