The Relationship between Blood Lipids Profile and Acne

El-Akawi, Zeyad; Abdel-Latif, N.; Abdul‐Razzak, Khalid K.; Al-Aboosi, Mustafa

doi:10.1248/jhs.53.596

Cited by 34 publications

(51 citation statements)

References 3 publications

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“…There is an increased sebum excretion in AV patients . However, changes in lipid profile are not detected, except in few studies . Chitinase‐3‐like protein 1 (YKL‐40) is one of the 18 glycosyl hydrolases, the conservative family of mammalian chitinases .…”

Section: Introductionmentioning

confidence: 99%

Serum YKL40: A novel potential link between inflammation and dyslipidemia in acne vulgaris

Ebrahim

Mustafa

El-Shimi

et al. 2019

J of Cosmetic Dermatology

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Background Acne vulgaris (AV) is an inflammatory skin disorder that may be associated with metabolic disorders. The relation between lipid profile in acne is not widely investigated. Chitinase‐3‐like protein 1 (YKL‐40) has been found to be implicated in different inflammatory conditions. Aims We aimed at investigating the role YKL‐40 in acne pathogenesis and associated dyslipidemia in acne patients. Patients/Methods This study included 50 acne vulgaris patients and 30 matched control subjects. Serum YKL‐40 in addition to lipid profile were assessed in all studied subjects. Results Serum YKL‐40 level was significantly elevated in acne patients than healthy controls (P < .001). We also found a significant positive correlations between serum YKL‐40, serum TGs, TC, and LDL‐C (P value: .022, .001, .017 respectively) while, a significant negative correlation between serum YKL‐40 and HDL‐c (P value: .036) was detected. Conclusion Our study results suggest that YKL‐40 might have a role in AV pathogenesis. In addition, it could provide a new potential link between inflammation and dyslipidemia observed in acne patients.

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Section: Introductionmentioning

confidence: 99%

Serum YKL40: A novel potential link between inflammation and dyslipidemia in acne vulgaris

Ebrahim

Mustafa

El-Shimi

et al. 2019

J of Cosmetic Dermatology

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“…Male and female acne patients have significantly low plasma high‐density lipoprotein cholesterol (HDL‐C) levels. Total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), testosterone and progesterone levels are elevated in acne patients . It indicates that the relationship of acne vulgaris and serum lipid profile needs further exploration.…”

Section: Introductionmentioning

confidence: 99%

“…Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), testosterone and progesterone levels are elevated in acne patients. 2,3 It indicates that the relationship of acne vulgaris and serum lipid profile needs further exploration. This study was designed to evaluate the relationship between plasma lipid profile and acne.…”

Section: Introductionmentioning

confidence: 99%

Acne patients frequently associated with abnormal plasma lipid profile

Jiang

Zhou

et al. 2015

The Journal of Dermatology

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This study was designed to investigate the relationship between plasma lipid profile and acne. Acne patients (n = 181) and healthy volunteers (n = 130) matched in terms of both age and sex were enrolled. Plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C) and lipoprotein (LP)(a) levels were measured. TC, LDL-C and LP(a) levels in male and female patients with severe acne were significantly higher than in the healthy control group (P < 0.05). TG in male patients with severe and moderate acne was significantly higher than in the healthy control group (P < 0.05). LP(a) in male and female patients with mild, moderate and severe acne was significantly higher than in the healthy control group (P < 0.05). The constituent ratio of male and female patients with TC, TG, LDL-C and LP(a) over the normal range was significantly higher than in the healthy control group. In this study, acne patients were frequently associated with abnormal lipid profile, providing a new basis for further exploration of the pathogenesis, as well as new treatments, of acne vulgaris.

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“…Regarding TG, in contrast to our result, no significant alterations were detected in patients with acne in da Cunha study . Zeyad et al observed that saturated fatty acids elevate TG and LDL, while carbohydrates lower HDL. They also added that most of the acne patients in Jordan consume foods rich in saturated fatty acids and carbohydrates, which affect level of LDL, HDL, and TG explaining the difference seen in the literature between these items in acne patients.…”

Section: Discussionmentioning

confidence: 99%

Impact of low ghrelin level in patients with postadolescent acne

Esaway

2019

J of Cosmetic Dermatology

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Summary Background Ghrelin is a 28 amino acid peptide predominantly produced by the stomach. There are many putative roles for ghrelin beyond homeostatic appetite control. Aim of the work To determine ghrelin's level in postadolescent acne and study its relationship to plasma lipid profile, IR and acne severity and to correlate variables. Patients and methods This is a case‐control study where 50 patients with postadolescent acne and 50 age‐sex compatible controls were enrolled. Acne severity was assessed according to the Hayashi acne grading criteria. The parameters measured were serum level of ghrelin, fasting blood glucose, total cholesterol, low‐density lipoprotein, high‐density lipoprotein, triglycerides, and insulin. Results The mean serum level of Ghrelin was significantly lower in patients compared to control group and acne severity had a significant effect on ghrelin's level. Serum levels of insulin, fasting glucose, HOMA‐IR, and TG were significantly increased in patients group compared to control. Serum TC, HDL, and LDL showed no significant difference between both studied groups. Ghrelin hormone had a positive correlation to HDL and a negative correlation to BMI, LDL, HOMA‐IR, and Insulin. Conclusion This study postulated that low level of ghrelin may predispose patients with postadolescent acne to hyperinsulinemia, type 2 diabetes or dyslipidemia.

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The Relationship between Blood Lipids Profile and Acne

Cited by 34 publications

References 3 publications

Serum YKL40: A novel potential link between inflammation and dyslipidemia in acne vulgaris

Serum YKL40: A novel potential link between inflammation and dyslipidemia in acne vulgaris

Acne patients frequently associated with abnormal plasma lipid profile

Impact of low ghrelin level in patients with postadolescent acne

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