The relationship between epidemic influenza A(H<sub>1</sub>N<sub>1</sub>) and ABO blood groups

Lebiush, M; Rannon, L; Kark, Jeremy D.

doi:10.1017/s002217240006931x

Cited by 21 publications

(16 citation statements)

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“…The 1960’s and 70’s saw a period of interest in the relationship between the ABO blood group and susceptibility to influenza infection. Studies involved observations of natural influenza infection [62] - [64] , experimental infection [65] , and serological studies [64] , [66] - [73] . The data are inconsistent, with authors reporting an increased risk of influenza in subjects with blood group O [62] , [65] , [66] , groups O and B [63] , [68] , B alone [67] , [74] , A [73] , A and B [64] , AB [64] , [71] , or no difference by blood group [69] , [70] , [72] .…”

Section: Resultsmentioning

confidence: 99%

“…Studies involved observations of natural influenza infection [62] - [64] , experimental infection [65] , and serological studies [64] , [66] - [73] . The data are inconsistent, with authors reporting an increased risk of influenza in subjects with blood group O [62] , [65] , [66] , groups O and B [63] , [68] , B alone [67] , [74] , A [73] , A and B [64] , AB [64] , [71] , or no difference by blood group [69] , [70] , [72] . One group examined the ability to excrete soluble ABO blood group antigens in body fluids (secretor) and the risk of respiratory viral infections, and found a positive association between being a ‘secretor’ and influenza A infection [75] .…”

Section: Resultsmentioning

confidence: 99%

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The Role of Host Genetics in Susceptibility to Influenza: A Systematic Review

et al. 2012

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Background The World Health Organization has identified studies of the role of host genetics on susceptibility to severe influenza as a priority. A systematic review was conducted to summarize the current state of evidence on the role of host genetics in susceptibility to influenza (PROSPERO registration number: CRD42011001380). Methods and Findings PubMed, Web of Science, the Cochrane Library, and OpenSIGLE were searched using a pre-defined strategy for all entries up to the date of the search. Two reviewers independently screened the title and abstract of 1,371 unique articles, and 72 full text publications were selected for inclusion. Mouse models clearly demonstrate that host genetics plays a critical role in susceptibility to a range of human and avian influenza viruses. The Mx genes encoding interferon inducible proteins are the best studied but their relevance to susceptibility in humans is unknown. Although the MxA gene should be considered a candidate gene for further study in humans, over 100 other candidate genes have been proposed. There are however no data associating any of these candidate genes to susceptibility in humans, with the only published study in humans being under-powered. One genealogy study presents moderate evidence of a heritable component to the risk of influenza-associated death, and while the marked familial aggregation of H5N1 cases is suggestive of host genetic factors, this remains unproven. Conclusion The fundamental question “Is susceptibility to severe influenza in humans heritable?” remains unanswered. Not because of a lack of genotyping or analytic tools, nor because of insufficient severe influenza cases, but because of the absence of a coordinated effort to define and assemble cohorts of cases. The recent pandemic and the ongoing epizootic of H5N1 both represent rapidly closing windows of opportunity to increase understanding of the pathogenesis of severe influenza through multi-national host genetic studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Role of Host Genetics in Susceptibility to Influenza: A Systematic Review

et al. 2012

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“…Whether this translates to changes in CD4+ response or clinical outcome is not known. A number of field observations have linked severity of influenza or vaccine response to HLA [61] – [64] but given the number of variables and the small size of some of these studies, no definitive conclusions could be drawn. Patients with DRB1*09:01 have been reported to respond less well to vaccination with H3N2 [65] , as have HLA-DR3 and DR4 patients [66] .…”

Section: Discussionmentioning

confidence: 99%

Patterns of Predicted T-Cell Epitopes Associated with Antigenic Drift in Influenza H3N2 Hemagglutinin

Homan

Bremel

2011

PLoS ONE

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Antigenic drift allowing escape from neutralizing antibodies is an important feature of transmission and survival of influenza viruses in host populations. Antigenic drift has been studied in particular detail for influenza A H3N2 and well defined antigenic clusters of this virus documented. We examine how host immunogenetics contributes to determination of the antibody spectrum, and hence the immune pressure bringing about antigenic drift. Using uTOPE™ bioinformatics analysis of predicted MHC binding, based on amino acid physical property principal components, we examined the binding affinity of all 9-mer and 15-mer peptides within the hemagglutinin 1 (HA1) of 447 H3N2 virus isolates to 35 MHC-I and 14 MHC-II alleles. We provide a comprehensive map of predicted MHC-I and MHC-II binding affinity for a broad array of HLA alleles for the H3N2 influenza HA1 protein. Each HLA allele exhibited a characteristic predicted binding pattern. Cluster analysis for each HLA allele shows that patterns based on predicted MHC binding mirror those described based on antibody binding. A single amino acid mutation or position displacement can result in a marked difference in MHC binding and hence potential T-helper function. We assessed the impact of individual amino acid changes in HA1 sequences between 10 virus isolates from 1968–2002, representative of antigenic clusters, to understand the changes in MHC binding over time. Gain and loss of predicted high affinity MHC-II binding sites with cluster transitions were documented. Predicted high affinity MHC-II binding sites were adjacent to antibody binding sites. We conclude that host MHC diversity may have a major determinant role in the antigenic drift of influenza A H3N2.

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“…A study by Lebiush et al. [ 21 ] on influenza A (H1N1) suggested a higher seroconversion to a titre of more than 20 in blood groups A and B. B blood group was also reported as a risk factor for prostate and bladder cancer [ 22 ], and non-O blood groups were reported to have a higher risk of gastric cancer [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between blood group and risk of infection and death in COVID-19: a live meta-analysis

Pourali¹,

Afshari

Alizadeh‐Navaei

et al. 2020

New Microbes and New Infections

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The relationship between ABO blood group and the incidence of coronavirus disease 2019 (COVID-19) infection and death has been investigated in several studies. The reported results were controversial, so the objective of the present study was to assess the relationship between different blood groups and the onset and mortality of COVID-19 infection using a meta-analysis method. We searched relevant databases using appropriate MeSH terms. We screened articles on the bases of titles, abstracts and full text, and articles that met the inclusion criteria were selected. Quality assessment was done with the Newcastle-Ottawa scale checklist. The estimated frequency of COVID-19 infection and death in terms of ABO blood group and the overall estimate of the odds ratio between blood group with COVID-19 infection and death was calculated with 95% confidence interval. The pooled frequency of blood groups A, B, O and AB among COVID-19–infected individuals was estimated as 36.22%, 24.99%, 29.67% and 9.29% respectively. The frequency of blood groups A, B, O and AB among patients who died of COVID-19 infection was estimated as 40%, 23%, 29% and 8% respectively. The odds ratio of COVID-19 infection for blood group A versus the other blood groups was estimated as 1.16 (95% confidence interval (CI), 1.02–1.33). The corresponding figures for blood groups O and AB versus other blood groups were estimated as 0.73 (95% CI, 0.60–0.88) and 1.25 (95% CI, 0.84–1.86) respectively. This meta-analysis showed that individuals with blood group A are at higher risk for COVID-19 infection while those with blood group O are at lower risk. Although the odds ratio of death for AB blood group was nonsignificant, it was considerable.

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The relationship between epidemic influenza A(H₁N₁) and ABO blood groups

Cited by 21 publications

References 10 publications

The Role of Host Genetics in Susceptibility to Influenza: A Systematic Review

The Role of Host Genetics in Susceptibility to Influenza: A Systematic Review

Patterns of Predicted T-Cell Epitopes Associated with Antigenic Drift in Influenza H3N2 Hemagglutinin

Relationship between blood group and risk of infection and death in COVID-19: a live meta-analysis

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The relationship between epidemic influenza A(H1N1) and ABO blood groups

Cited by 21 publications

References 10 publications

The Role of Host Genetics in Susceptibility to Influenza: A Systematic Review

The Role of Host Genetics in Susceptibility to Influenza: A Systematic Review

Patterns of Predicted T-Cell Epitopes Associated with Antigenic Drift in Influenza H3N2 Hemagglutinin

Relationship between blood group and risk of infection and death in COVID-19: a live meta-analysis

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The relationship between epidemic influenza A(H₁N₁) and ABO blood groups