The Relationship Between Foveal Avascular Zone Area, Vessel Density, and Cystoid Changes in Diabetic Retinopathy

Tarassoly, Kia; Miraftabi, Arezoo; Sanjari, Mostafa Soltan; Parvaresh, Mohammad Mehdi

doi:10.1097/iae.0000000000001755

Cited by 21 publications

(14 citation statements)

References 16 publications

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“…[ 49 62 ] It is important to point out that presence of CME may not influence the reproducibility and effectiveness of OCTA in the measurement of FAZ in SCP. [ 8 88 ] FAZ has been found to have no or the least correlation among other vascular indices with systemic indicators like HbA1c and duration of DM;[ 17 66 ] however, in one study, FAZ size was found to be correlated with HbA1c. [ 61 ] These should be confirmed in larger studies and considered in the design of studies and interpretation of results.…”

Section: Resultsmentioning

confidence: 99%

“…[ 18 20 36 44 64 ] While interpreting the results, one should consider that the presence of CME may influence reproducibility and effectiveness of OCTA in the measurement of FAZ and vascular indices, particularly in DCP. [ 8 88 ] Eyes with DME that showed outer plexiform layer (OPL) disruption, loss of integrity of the DCP, larger FAZ area, and more MAs in DCP had poor response to anti-VEGF treatment. [ 36 ] Size of FAZ and VD did not change following IDI and anti-VEGF therapy but a reduction in the caliber of DCP vessels and an increase in CCCD was observed.…”

Section: Resultsmentioning

confidence: 99%

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An update on optical coherence tomography angiography in diabetic retinopathy

Khadamy¹,

Aghdam²,

Falavarjani³

2018

J Ophthalmic Vis Res

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Optical coherence tomography angiography (OCTA) is a novel non-invasive imaging modality for 3-dimensional visualization of retinal and optic nerve capillary networks. In this article, a comprehensive review of relevant original articles in the PubMed database was performed using the search terms “diabetic retinopathy,” “diabetic macular edema,” “diabetes mellitus,” and “optical coherence tomography angiography.” OCTA was found to detect microvascular changes early in diabetes mellitus, even before they become clinically evident. Morphological and qualitative assessment of vascular changes can help to determine the pathophysiological processes, activity, treatment, and follow-up of diabetic retinopathy (DR). Vessel density and foveal avascular zone are the most investigated quantified indices shown to be early predictors of DR, correlated to DR severity and visual function, and useful in predicting response to treatment. OCTA has shown to be a promising alternative to fluorescein angiography in the management of DR. Further studies are warranted to determine the role of OCTA in the routine clinical management of DR.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

An update on optical coherence tomography angiography in diabetic retinopathy

Khadamy¹,

Aghdam²,

Falavarjani³

2018

J Ophthalmic Vis Res

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“…However, recent evidence suggests that vessel density measurement of the DP may be influenced by the presence of coexisting macular edema due to the interference with image segmentation 27 28 while the SP vessel density may be independent of the presence of cystoid edema. 29 Technologic limitations of SS-OCTA, including increased variability with different axial lengths 30 and the impact of patient cooperation on image quality, introduce an intrinsic bias to our study that needs to be taken into account when drawing definitive conclusions.…”

Section: Concerning Qualitative Macroscopic Analysis Despite the Prementioning

confidence: 98%

Comparing Fundus Fluorescein Angiography and Swept-Source Optical Coherence Tomography Angiography in the Evaluation of Diabetic Macular Perfusion

Mantia

Kurt

Mejor

et al. 2019

Retina

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“…; Tarassoly et al. ). However, at the time of this study, OCT angiography was not available and OCT algorithms measuring the macular capillary network in three dimensions remain in development.…”

Section: Discussionmentioning

confidence: 98%

Patterns of morphologic alteration correlate with vision in diabetic macular oedema: a cross‐sectional evaluation of patients using the SAVE II protocol

Bolz

Podkowinski

Pretzl

et al. 2019

Acta Ophthalmologica

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Purpose: We sought to describe and evaluate patients with clinically significant diabetic macular oedema (CSME) according to the improved SAVE II protocol and correlate findings with visual acuity and systemic parameters in the outpatient clinic for DR (diabetic retinopathy) management. Methods: This was a cross-sectional case series study of patients with CSME, regardless of prior treatment. Visual acuity testing was performed according to the Early Treatment of Diabetic Retinopathy Study (ETDRS) protocol. Optical coherence tomography (OCT) and fluorescence angiography (FA) were performed. All imaging data were evaluated according to an improved version of the SAVE grading protocol for CSME (SAVE II). The main outcome measures were SAVE II oedema types and best-corrected visual acuity. Additional parameters of a blood sample (fasting glucose, haemoglobin A1c, serum creatinine, triglycerides, cholesterol, low-density lipoproteins, and high-density lipoproteins) were taken. Results: In total, 66 eyes of 66 patients were included. The mean age of the patients was 64.9 AE 8.2 years. Two eyes were classified as SAVE oedema type 1, 19 eyes as SAVE oedema type 2, 28 eyes as SAVE oedema type 3, and 28 eyes as SAVE oedema type 4, respectively. Central retinal thickness and laboratory parameters were not significantly different between the groups. There was a statistically significant difference in ETDRS visual acuity between the SAVE groups 2 and 4 (p < 0.001) with lower vision in group 4. There was no statistically significant difference between oedema types 2 and 3 (p = 0.065) and oedema types 3 and 4 (p = 0.13). Conclusion: There was a significant correlation between the four defined oedema types and visual acuity. Morphologic findings did not correlate with any of the evaluated blood parameters.

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The Relationship Between Foveal Avascular Zone Area, Vessel Density, and Cystoid Changes in Diabetic Retinopathy

Abstract: The FAZ area and vessel density at the superficial capillary plexus level are reproducible and independent of the presence of cystoid edema.

Cited by 21 publications

References 16 publications

An update on optical coherence tomography angiography in diabetic retinopathy

An update on optical coherence tomography angiography in diabetic retinopathy

Comparing Fundus Fluorescein Angiography and Swept-Source Optical Coherence Tomography Angiography in the Evaluation of Diabetic Macular Perfusion

Patterns of morphologic alteration correlate with vision in diabetic macular oedema: a cross‐sectional evaluation of patients using the SAVE II protocol

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