The relationship between hippocampal subfield volumes and autobiographical memory persistence

Barry, Daniel N.; Clark, Ian A.; Maguire, Eleanor A.

doi:10.1002/hipo.23293

Cited by 26 publications

(37 citation statements)

References 84 publications

(130 reference statements)

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“…We speculate that this difference may arise from underpowered samples in previous work or variation in AI administration (e.g., time limits for participant responses). The vast majority of AI studies to date have relied on internal count measures (e.g., Palombo et al, 2018;Barry et al, 2020;Armson et al, 2021 for recent examples), but our findings provide evidence that density and proportion scores may provide a better estimate of autobiographical episodicity. The modest negative correlation between internal density and internal count observed here suggests they are measuring different constructs and should not be used interchangeably.…”

Section: Internal Consistencymentioning

confidence: 62%

Taking stock of the past: A psychometric evaluation of the Autobiographical Interview

Lockrow

Setton

Spreng

et al. 2021

Preprint

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Autobiographical memory (AM) involves a rich phenomenological re-experiencing of a spatio-temporal event from the past, which is challenging to objectively quantify. The Autobiographical Interview (AI; Levine et al., 2002, Psychology & Aging) is a manualized performance-based assessment designed to quantify episodic (internal) and semantic (external) features of recalled and verbally conveyed prior experiences. The AI has been widely adopted yet has not undergone a comprehensive psychometric validation. We investigated the reliability, validity, association to individual differences measures, and factor structure in healthy younger and older adults (N=352). Evidence for the AI's reliability was strong: the subjective scoring protocol showed high inter-rater reliability and previously identified age effects were replicated. Internal consistency across timepoints was robust, suggesting stability in recollection. Central to our validation, internal AI scores were positively correlated with standard, performance-based measures of episodic memory, demonstrating convergent validity. The two-factor structure for the AI was not well-supported by confirmatory factor analysis. Adjusting internal and external detail scores for the number of words spoken (detail density) improved trait estimation of AM performance. Overall, the AI demonstrated sound psychometric properties for inquiry into the qualities of autobiographical remembering.

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Section: Internal Consistencymentioning

confidence: 62%

Taking stock of the past: A psychometric evaluation of the Autobiographical Interview

Lockrow

Setton

Spreng

et al. 2021

Preprint

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“…The hippocampus is composed of distinct subfields, and myelination or iron content in specific subregions may be associated with task performance, as opposed to associations being apparent at the level of the whole hippocampus. Some evidence exists to suggest this may be the case for hippocampal grey matter volume ( Barry et al, 2021 ; Chadwick et al, 2014 ; Palombo et al, 2018 ), and future studies could investigate relationships between task performance and subfield-specific hippocampal grey matter tissue microstructure.…”

Section: Discussionmentioning

confidence: 99%

The relationship between hippocampal-dependent task performance and hippocampal grey matter myelination and iron content

Clark

Callaghan

Weiskopf

et al. 2021

Brain and Neuroscience Advances

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Individual differences in scene imagination, autobiographical memory recall, future thinking and spatial navigation have long been linked with hippocampal structure in healthy people, although evidence for such relationships is, in fact, mixed. Extant studies have predominantly concentrated on hippocampal volume. However, it is now possible to use quantitative neuroimaging techniques to model different properties of tissue microstructure in vivo such as myelination and iron. Previous work has linked such measures with cognitive task performance, particularly in older adults. Here we investigated whether performance on scene imagination, autobiographical memory, future thinking and spatial navigation tasks was associated with hippocampal grey matter myelination or iron content in young, healthy adult participants. Magnetic resonance imaging data were collected using a multi-parameter mapping protocol (0.8 mm isotropic voxels) from a large sample of 217 people with widely-varying cognitive task scores. We found little evidence that hippocampal grey matter myelination or iron content were related to task performance. This was the case using different analysis methods (voxel-based quantification, partial correlations), when whole brain, hippocampal regions of interest, and posterior:anterior hippocampal ratios were examined, and across different participant sub-groups (divided by gender and task performance). Variations in hippocampal grey matter myelin and iron levels may not, therefore, help to explain individual differences in performance on hippocampal-dependent tasks, at least in young, healthy individuals.

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“…With respect to hippocampal outputs via fornix (Gilboa et al, 2006) and subfields, such as CA1 (Bartsch et al, 2011) and CA3 (Miller et al, 2020), damage or dysfunction led to extended retrograde amnesia to episodic, but not semantic, aspects, with CA3 posited to be necessary for integrating information along the cortical default mode network (Miller et al, 2020). The persistence of autobiographical memory details is also related to the volume of the left pre-and para-subiculum, although evidence from lesion studies in humans about the role of the subiculum is lacking at the moment (Barry et al, 2021).…”

Section: Lesionsmentioning

confidence: 99%

No consolidation without representation: Correspondence between neural and psychological representations in recent and remote memory

Gilboa

Moscovitch

2021

Neuron

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The relationship between hippocampal subfield volumes and autobiographical memory persistence

Cited by 26 publications

References 84 publications

Taking stock of the past: A psychometric evaluation of the Autobiographical Interview

Taking stock of the past: A psychometric evaluation of the Autobiographical Interview

The relationship between hippocampal-dependent task performance and hippocampal grey matter myelination and iron content

No consolidation without representation: Correspondence between neural and psychological representations in recent and remote memory

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