The relationship between mean platelet volume and neutrophil/lymphocyte ratio with inflammation and proteinuria in chronic kidney disease

Yılmaz, Gülay; Sevinç, Can; Üstündağ, Sedat; Yavuz, Yasemin; Hacıbekiroğlu, Tuba; Hatipoğlu, Esra; Baysal, Mehmet

doi:10.4103/1319-2442.198152

Cited by 36 publications

(10 citation statements)

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“…This was in agreement with Yilmaz [22] who reported that MPV was lower in patients with CKD compared to healthy individual but this was not statistically significant. Also, Bilen [7] , showed that the study with 200 patients with CKD (50 kidney transplantation, 50 hemodialysis, 50 peritoneal dialysis, 50 and stage 3-4 CKD reported no statistical difference of MPV between all groups.…”

Section: Discussionsupporting

confidence: 91%

“…Also, Binnetoglu [34] showed that study in 69 patients with stage 3 and 4 CKD not diabetic or malignant found NLR is a marker with prognostic value for the presence and degree of proteinuria. Also, Yilmaz [22] showed that study in fifty-three stage (3-4) CKD patients and 30 healthy controls. Patients with diabetes mellitus, active infection, malignancy, and coronary artery disease were excluded and found that NLR is high in CKD patients and is correlated with proteinuria.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Mean Platelet Volume and Neutrophil/Lymphocyte Ratio in Chronic Kidney Disease Patients with Proteinurea

Seliem¹,

El-Salam

2019

The Medical Journal of Cairo University

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Background: Chronic kidney disease is a chronic inflammatory process which is the main cause of developing atherosclerosis. The main reason of morbidity and mortality in Chronic Kidney Disease (CKD) is atherosclerosis. Mean Platelet Volume (MPV) and Neutrophil to Lymphocyte Ratio (NLR) have been reported as markers of systemic inflammation. Aim of Study: To assess the value of Mean Platelet Volume (MPV) and Neutrophil to Lymphocyte (NLR) in chronic kidney disease patients with proteinurea. Methods: The study was carried out on two groups: Group (I): 50 CKD patients and Group (II): 50 healthy individuals as a control group. The patients were from Outpatient Clinic of Nephrology in Tanta University Hospital. This study was carried out from August 2017 to February 2018. We excluded patients suffer from coronary artery disease, myocardial infarction and heart failure, patients suffer from active infection, patients suffer from diabetes mellitus and patients suffer from malignancy. Complete clinical examination including: Body Mass Index (BMI) and routine laboratory investigations and specific investigations including Neutrophil Lymphocyte Ratio (NLR) and Mean Platelet Volume (MPV) were done. Results: NLR was statistical significance higher in patients group than control healthy groups (Z mw =-7.38, p<.001) and there were statistically significant positive correlation were detected between NLR and proteinuria (p<.001*), CRP (p <.001*), fibrinogen (p<.001 *) and negative correlation with eGFR (p<.001 *). There was not statistical difference of MPV between patients group and control healthy group (t=-.510, p=.611) and there were not statistically significant correlation between MPV and proteinuria (p=.416), CRP (p=.641) and eGFR (p=.557). Conclusion: NLR could be used as a marker of inflammation and proteinuria in CKD stages but MPV needs more researches in this field.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Assessment of Mean Platelet Volume and Neutrophil/Lymphocyte Ratio in Chronic Kidney Disease Patients with Proteinurea

Seliem¹,

El-Salam

2019

The Medical Journal of Cairo University

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“…Interestingly, MPV was found to be a risk factor for renal function with OR=1.992 ( P =0.005). Some studies have documented the association between MPV and inflammation [48]. The mechanism may be as follows, the heart failure process is also a process of inflammatory, increased inflammatory mediators may affect MPV, then it might induce larger and more reactive platelets [49].…”

Section: Discussionmentioning

confidence: 99%

Association Between the Lipid Profile and Renal Dysfunction in the Heart Failure Patients

Zhang

Shi

Zhao

et al. 2019

Kidney Blood Press Res

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Background/Aims: In heart failure patients with high prevalence of chronic renal disease (CKD), hospitalization and mortality, whether the lipid profile was associated with renal dysfunction remained unknown. The present study intended to clarify the association between the lipid profile and renal dysfunction in the heart failure patients. Methods: 336 hospitalized heart failure patients with left ventricle ejection fraction (LVEF) ≤45% and New York Heart Association (NYHA) class II-IV were enrolled. The estimated glomerular filtration rate (eGFR) < 90 mL/min·1.73 m² was defined as renal dysfunction. The demographic, clinical data, blood samples and echocardiography were documented. The Pearson simple linear correlation was performed to evaluate the confounding factors correlated with eGFR. The significantly correlated factors were enrolled in Logistic regression as confounding factors to determine the association between the lipid profile and renal dysfunction in the heart failure patients. Results: 182 patients (54.2%) had renal dysfunction and 154 patients (45.8%) did not have renal dysfunction. The waist circumference, platelet counts, platelet distribution width (PDW), high density lipoprotein-cholesterol (HDL-C), apolipoprotein A1 (apoA1), albumin and left ventricular ejection fraction (LVEF) are positively correlated with eGFR (all P< 0.05). Meanwhile, the age, mean platelet volume (MPV), neutrophilic granulocyte percentage (NEUT%), urea nitrogen (BUN), creatinine and total bilirubin (TBIL) are negatively correlated with eGFR (all P< 0.05). The total cholesterol (TC), triglyceride, low density lipoprotein-cholesterol (LDL-C) and apolipoprotein B (apoB) show no correlation with eGFR. After the adjustment of sex, hypertension, diabetes mellitus, age, waist circumference, platelet counts, MPV, PDW, NEUT%, TBIL, albumin and LVEF, HDL-C is the only lipid factor still significantly associated with renal dysfunction in hospitalized heart failure patients (OR=0.119, P=0.003). Conclusion: Among the lipid profile of TC, triglyceride, LDL-C, HDL-C, apo A1 and apo B, the HDL-C is the only lipid factor significantly associated with renal dysfunction in hospitalized heart failure patients.

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“…21 It is known that inflammation begins in the early stages of CKD. 7,8 Our study showed an increase in CRP values with the progression of renal impairment and found a statistically significant difference in the values of serum concentration of CRP between all groups of subjects with different stages of CKD. Liu et al have investigated the inflammatory status in subjects with CKD, dividing them into three groups: CKD 1-2, CKD 3-4, and CKD-5.…”

Section: Discussionmentioning

confidence: 48%

“…Published papers report increased levels of CRP in patients with CKD compared with healthy controls. [6][7][8] New hematological inflammatory markers have emerged in the past few years, such as the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), which increase during chronic inflammation. [9][10][11][12][13][14] Their predictive and prognostic role has been proven in malignancy, hypertension, heart disease, vascular disease, but also CKD.…”

Section: Introductionmentioning

confidence: 99%

Assessment of C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients at Different Stages of Chronic Kidney Disease

Klapuh-Bukvić

Serdarevic

Uncanin

et al. 2022

Journal of Interdisciplinary Medicine

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Background: Low-grade chronic inflammation is an important feature of chronic kidney disease (CKD). Aim: To determine the values of C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with different stages of CKD and to examine how they change depending on the progression of renal damage. Materials and methods: A cross-sectional descriptive comparative study included 157 subjects at different stages of CKD which was assessed based on glomerular filtration rate (GFR) calculated according to the MDRD equation. CRP was analyzed by an immunoturbidimetric method. NLR and PLR were calculated by a mathematical calculation after a blood count was performed. Results: The present study showed an increase in serum creatinine, CRP, and NLR values with progression of renal failure. There was a statistically significant difference in the creatinine and CRP concentrations between groups with different stages of CKD (p <0.001 for all comparisons). A significant positive correlation was found between NLR and CRP, while negative, significant correlations were observed between NLR and eGFR as well as between PLR and eGFR. There was a slight increase in PLR value with the progression of renal impairment, but the correlation between PLR and CRP was not significant. Conclusion: These results suggest that NLR, together with CRP, may serve as an indicator of systemic low-grade inflammation progression in patients with CKD. Larger prospective studies are required to observe the possibility of using NLR as a surrogate marker for CRP in patients with CKD.

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The relationship between mean platelet volume and neutrophil/lymphocyte ratio with inflammation and proteinuria in chronic kidney disease

Cited by 36 publications

References 0 publications

Assessment of Mean Platelet Volume and Neutrophil/Lymphocyte Ratio in Chronic Kidney Disease Patients with Proteinurea

Assessment of Mean Platelet Volume and Neutrophil/Lymphocyte Ratio in Chronic Kidney Disease Patients with Proteinurea

Association Between the Lipid Profile and Renal Dysfunction in the Heart Failure Patients

Assessment of C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients at Different Stages of Chronic Kidney Disease

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