The Relationship between Metabolic Syndrome and Pulmonary Function

Abstract

BackgroundImpaired lung function is associated with mortality rate from cardiovascular and all other death causes. There were previous studies on the relationship between lung function impairment and metabolic syndrome, but they are insufficient. This study was conducted on Koreans to analyze each component of metabolic syndrome as well as its variability between sexes.Methods1,370 subjects underwent a health examination at the Eulji General Hospital Health Center. We examined the association between lung function measurement (forced expiratory volume for 1 second [FEV1], forced vital capacity [FVC], FEV1/FVC) and metabolic syndrome using Student t-test, Pearson partial correlation coefficient, and analysis of covariance for statistical analysis, and we adopted metabolic syndrome defined by American Heart Association/National Heart, Lung, and Blood Institute in Asia.ResultsMen with metabolic syndrome tended to experience lung function impairment. In terms of association to each metabolic syndrome component, metabolic syndrome components in men were associated with pulmonary function impairment and the more metabolic syndrome diagnostic criteria factors the patients had, the more severe their pulmonary function tended to decline. In women, waist circumference, triglyceride and high-density lipoprotein cholesterol were associated with pulmonary function change.ConclusionIn men, all metabolic syndrome components were associated with pulmonary function impairment, and the more metabolic syndrome components men had, the more severe their pulmonary functions decline. In women, components of metabolic syndrome were not associated with pulmonary function impairment.

Lung function and metabolic syndrome: Findings of National Health and Nutrition Examination Survey 2007–2010 肺功能与代谢综合征：2007–2010全国健康与营养调查研究结果

“…Adjustments were made for age, gender, education, smoking status, abdominal obesity, height, hypertension, physical activity, and center. In a Korean study that included 1370 patients aged 20–70 years who had a health examination in 2008, men who had metabolic syndrome had higher mean levels of FEV 1 and FVC than men without metabolic syndrome, and women with metabolic syndrome had higher levels of FEV 1 and FEV 1 /FVC than women without metabolic syndrome . Furthermore, FEV 1 and FVC both declined as a function of the number of metabolic syndrome components in men, but the pattern in women was irregular.…”

The association between the metabolic syndrome and metabolic syndrome score and pulmonary function in non-smoking adults

“…[11][12][13] Recently, research on MetS and pulmonary function has gained momentum worldwide. [14][15][16][17][18] However, to our knowledge, no study involving large-scale populations to assess the relationship between MetS and decreased pulmonary function in non-smoking adults has been conducted. In addition, it is unclear whether the association can be observed in Korean populations.…”

Spirometric prediction equations and the relationship between metabolic syndrome and spirometric parameters from an island in Fujian, China

“…This indicates that MS is related to restrictive, rather than obstructive, pulmonary dysfunction. Others have also shown that MS is associated with a reduction in FVC%pred and FEV1%pred. The restrictive pulmonary dysfunction seen in MS is probably due to the increased WC.…”

“…In some studies, it has been reported that poor lung function is seen in those with hypertension, type 2 diabetes, low density lipoprotein cholesterol and abdominal obesity . As the obese population has increased, the incidence of metabolic syndrome (MS) has increased, and there has been a recent report on the relationship between the diagnostic criteria for MS and changes in pulmonary function . But current reference values for lung function are obtained from populations that do not exclude the influence on these values of including individuals with hypertension, diabetes mellitus or obesity .…”