The Relationship between New Stroke Onset and Serum Thiocyanate as an Indicator to Cigarette Smoking.

Abstract

The case subjects were 67 stroke patients (27 males and 40 females, mean age 65.7+/-7.1), who suffered from stroke attack and had participated in annual medical check-up between 1987 and 1988 at Oyabe Public Health Center. The controls, which were adjusted for sex, age and blood pressure level with the case subjects, were selected from participants attending their annual medical check-up in 1987-1988. The serum thiocyanate level of case subjects were significantly higher than that of controls (p<0.05). The usefulness of measurement of serum thiocyanate level as an indicator of smoking status was assessed by using multiple logistic regression analysis adjusting for body mass index, mean blood pressure, and serum cholesterol was found. An odds ratio of 3.00 (95% confidence interval: 1.06-8.48, p<0.05) in cerebral infarction. It is considered that serum thiocyanate may be useful as an indicator of smoking status to assess the relationship with stroke onset, especially for cerebral infarction.

Determination of Cyanide and Thiocyanate in Sugihiratake Mushroom Using HPLC Method with Fluorometric Detection

“…21) In addition, a recent study showed that the risk of cerebral infarction stroke was significantly increased in individuals having high serum thiocyanate concentrations. 22) There also is some evidence that thiocyanate enhances the action of glutamate in a subclass of neuronal glutamate receptors which are involved in the neurodegenerative disorders. 23) These results suggested that the ingestion of cyanide from foods could also induce the accumulation of cyanide and thiocyanate in the blood of patients with chronic kidney diseases and might be associated with the onset of encephalopathy.…”

Accumulation of cyanide and thiocyanate in haemodialysis patients

“…In addition, serum SCN is positively correlated with the formation of advanced atherosclerotic plaques within coronary arteries [2]. Furthermore, a recent study showed that risk of cerebral infarction stroke was significantly increased in individuals having high serum SCN concentrations, with an odds ratio of 3.00 [3]. However, the mechanisms through which SCN accelerates atherosclerosis have not been well clarified.…”

The Acute Encephalopathy Induced by Intake of Sugihiratake Mushroom in the Patients with Renal Damage Might Be Associated with the Intoxication of Cyanide and Thiocyanate

“…H igh-dose Recently, the sodium iodide symporter, mediating active iodide transport into the thyroid, the lactating mammary gland and placenta, was found to be competitively inhibited by thiocyanate from maternal smoking for the intoxication of thiocyanate 25) . In addition, a recent study has also shown that the risk of cerebral infarction is significantly increased in individuals with high thiocyanate concentrations in the hemolyzed blood 26) .…”