The relationship between plasma and red cell concentrations of vitamins thiamine diphosphate, flavin adenine dinucleotide and pyridoxal 5-phosphate following elective knee arthroplasty

Gray, Andrew; McMillan, Donald C.; Wilson, Chris; Williamson, Cathy; O’Reilly, Denis St. J.; Talwar, Dinesh

doi:10.1016/j.clnu.2004.01.013

Cited by 50 publications

(33 citation statements)

References 9 publications

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“…We have recently shown that in apparently healthy individuals undergoing an acute inflammatory insult, circulating concentrations of vitamin E and carotenoids are transiently decreased, but when results were adjusted for the decrease in the lipid component of plasma (cholesterol) there were no significant alterations (28,29 ). In the present study we have shown that phylloquinone concentration in plasma responds similarly, falling transiently by almost 50% after an acute inflammatory insult.…”

Section: 33 )supporting

confidence: 50%

“…We also examined the relationship between phylloquinone and triglyceride concentrations in plasma to establish a phylloquinone population reference interval expressed as a ratio to the triglyceride concentration. Because systemic inflammatory response is associated with a decrease in plasma triglyceride concentrations (28 ) and may lower vitamin concentrations independently of tissue stores (28,29 ), we also examined the effect of acute systemic inflammatory response on phylloquinone concentrations in plasma.…”

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confidence: 99%

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HPLC Method for Plasma Vitamin K1: Effect of Plasma Triglyceride and Acute-Phase Response on Circulating Concentrations

et al. 2007

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Background:The plasma concentration of vitamin K 1 (phylloquinone) is the most reliable index for assessing vitamin K status. Our aim was to analytically validate an HPLC method for quantifying phylloquinone in plasma and to examine the effect of plasma triglyceride concentration on the phylloquinone reference interval. We also examined the effect of acute-phase response on phylloquinone concentration in plasma. Methods: Phylloquinone was extracted from fasting plasma samples by deproteinization and C18 solidphase extraction, separated by reversed-phase HPLC, and detected fluorometrically after postcolumn reduction with a platinum catalyst. We synthesized a novel internal calibrator, docosyl naphthoate. Results: The recovery of phylloquinone was >90%. Between-run imprecision was 8.7%-9.0%, and withinrun imprecision was 3.8%-7.0%. The linearity was up to 44.8 nmol/L, limit of detection 0.08 nmol/L, and limit of quantification 0.14 nmol/L. The correlation between plasma phylloquinone and triglyceride concentrations was r ‫؍‬ 0.7 in the reference population. The 95% reference interval for the phylloquinone:triglyceride ratio was 0.20 to 2.20 nmol/mmol. Plasma concentrations of C-reactive protein were significantly increased, whereas triglyceride and phylloquinone but not the phylloquinone:triglyceride ratio were transiently decreased >50% after surgery.

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Section: 33 )supporting

confidence: 50%

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confidence: 99%

HPLC Method for Plasma Vitamin K1: Effect of Plasma Triglyceride and Acute-Phase Response on Circulating Concentrations

et al. 2007

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“…A possible explanation might be that the use and turnover of plasma PLP increased or redistributed PLP from plasma to erythrocyte in an acute systemic inflammatory response (Talwar et al, 2003;Gray et al, 2004;Quasim et al, 2005); plasma PLP, therefore, was negatively associated with CRP level in our earlier study, which included critically ill patients (Huang et al, 2005), and in other studies (Friso et al, 2001(Friso et al, , 2004Kelly et al, 2004). However, RA is a chronic rather than acute inflammatory disease; our RA patients had not only adequate but also relatively high plasma PLP concentrations before the intervention (week 0).…”

Section: Discussionmentioning

confidence: 99%

Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis

Wei

et al. 2010

Eur J Clin Nutr

112

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Background/Objectives: The purpose of this study was to investigate whether vitamin B 6 supplementation had a beneficial effect on inflammatory and immune responses in patients with rheumatoid arthritis (RA). Subjects/Methods: This was a single-blind co-intervention study performed at the Division of Allergy, Immunology and Rheumatology of Chung Shan Medical University Hospital, Taiwan. Patients were diagnosed with RA according to the 1991 American College of Rheumatology criteria for RA. Patients were randomly allocated into two groups: control (5 mg/day folic acid only; n ¼ 15) or vitamin B 6 (5 mg/day folic acid plus 100 mg/day vitamin B 6 ; n ¼ 20) for 12 weeks. Plasma pyridoxal 5 0 -phosphate (PLP), serum folate, inflammatory parameters (that is, high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a)) and immune parameters (that is, white blood cell, total lymphocyte, T-cell (CD3), B-cell (CD19), T-helper cell (CD4), T-suppressor (CD8)) were measured on day 1 (week 0) and after 12 weeks (week 12) of the intervention. Results: In the group receiving vitamin B 6 , plasma IL-6 and TNF-a levels significantly decreased at week 12. There were no significant changes with respect to immune responses in both groups except for the percentage of total lymphocytes in the vitamin B 6 group when compared with week 0 and week 12. Plasma IL-6 level remained significantly inversely related to plasma PLP after adjusting for confounders (b ¼ À0.01, P ¼ 0.01). Conclusions: A large dose of vitamin B 6 supplementation (100 mg/day) suppressed pro-inflammatory cytokines (that is, IL-6 and TNF-a) in patients with RA.

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“…The increase in the percentage of T3 þ and T4 þ cells has been suggested to affect the differentiation of immature T cells to mature T cells by vitamin B 6 supplementation in healthy elderly (Talbott et al, 1987). In the study of Gray et al (2004), patients who underwent an elective knee arthroplasty had a significant increase in circulatory CRP concentrations and there was a significant fall in plasma PLP concentration but red cell PLP remained stable. This may be that critically ill patients were under severe stress during the systemic inflammatory response, which may have increased the turnover and utilization of plasma PLP, decreased hepatic PLP reserves (Louw et al, 1992), or redistributed PLP from plasma to erythrocyte (Talwar et al, 2003a;Gray et al, 2004;Quasim et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…In the study of Gray et al (2004), patients who underwent an elective knee arthroplasty had a significant increase in circulatory CRP concentrations and there was a significant fall in plasma PLP concentration but red cell PLP remained stable. This may be that critically ill patients were under severe stress during the systemic inflammatory response, which may have increased the turnover and utilization of plasma PLP, decreased hepatic PLP reserves (Louw et al, 1992), or redistributed PLP from plasma to erythrocyte (Talwar et al, 2003a;Gray et al, 2004;Quasim et al, 2005). Quasim et al (2005), therefore, suggested that direct measurements of red cell PLP are more responsive to supplementation than plasma measurements in the critically ill patients.…”

Section: Discussionmentioning

confidence: 99%

Vitamin B6 supplementation increases immune responses in critically ill patients

Cheng

Chang²,

Lee

et al. 2006

Eur J Clin Nutr

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The relationship between plasma and red cell concentrations of vitamins thiamine diphosphate, flavin adenine dinucleotide and pyridoxal 5-phosphate following elective knee arthroplasty

Cited by 50 publications

References 9 publications

HPLC Method for Plasma Vitamin K1: Effect of Plasma Triglyceride and Acute-Phase Response on Circulating Concentrations

HPLC Method for Plasma Vitamin K1: Effect of Plasma Triglyceride and Acute-Phase Response on Circulating Concentrations

Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis

Vitamin B6 supplementation increases immune responses in critically ill patients

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