The Relationship Between Serum Selenium Concentration and Neutrophil Function in Peripheral Blood

Lee, Sangun; Takahashi, Ippei; Matsuzaka, Masashi; Yamai, Kiyonori; Danjo, Kazuma; Kumagai, Takako; Umeda, Takashi; Itai, Kazuyoshi; Nakaji, Shigeyuki

doi:10.1007/s12011-011-9108-8

Cited by 11 publications

(9 citation statements)

References 36 publications

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“…This suggests that there may have been a residual effect from the previous supplementation with the micronutrient in these individuals, thus justifying the sustained neutrophil count. Thus we can say that, as noted by other authors, 22,31,32 selenium usage is able to perform a beneficial role on the viability of neutrophils in patients undergoing conditions of increased oxidative stress, such as the patients we studied. It is noteworthy that new studies should be conducted to assess the function of these cells and identify whether this supplementation influences the chemotaxis and digestion of the material phagocytosed by the cell.…”

Section: Discussionsupporting

confidence: 75%

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Impact of Selenium Supplementation in Neutropenia and Immunoglobulin Production in Childhood Cancer Patients

Rocha

Vieira

Beltrame

et al. 2016

Journal of Medicinal Food

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Essential to human health, selenium (Se) has enzymatic functions of fundamental importance to human biology due to its effects on DNA damage repair, its antioxidant properties, and cancer prevention. The best studied relationships between Se and the immune system is its role in the functions of neutrophils and of lymphocytes. Despite these observations, it is not yet clear by which mechanism Se is able to modify the immune status. This was a double-blind, crossover study: Group 1 received Se and Group 2 received placebo (30 days). After this, Group 1 received placebo and Group 2 received Se (30 days). Every 30 days, blood samples were collected for white blood cell count, red blood cell count, and Ig level measurement (IgA, IgG, IgE, IgM). Of the 36 patients, 17 were suffering from leukemia/lymphomas (LL) and 19 from solid tumors (ST). In the ST group's leukogram, a significant increase in neutrophils was observed after Se usage (P = .0192). During the analyzed period, Se minimized the triggering of neutropenia cases in both groups. IgA and IgG levels in ST patients were significantly higher than those identified in LL patients after Se usage (P = .0051 and P = .0055). For IgA, a significant increase in its production, after Se usage, was observed in the ST group when compared to the LL (P = .0011). The same did not occur to the IgM and IgE immunoglobulins. In our study, the supplementation with Se reduced the neutropenic cases (LL and ST patients) and reduced IgG and IgA levels in LL and increased in ST group.

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Section: Discussionsupporting

confidence: 75%

“…21,22,32 The decrease in serum levels of selenium can not only lead to the fall in the number of circulating neutrophils but can also cause changes in lymphocyte functions due to a lower bioavailability of the micronutrient. Through studies …”

Section: Discussionmentioning

confidence: 99%

Impact of Selenium Supplementation in Neutropenia and Immunoglobulin Production in Childhood Cancer Patients

Rocha

Vieira

Beltrame

et al. 2016

Journal of Medicinal Food

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“…Although, no significant differences were reported in Se and in Zn in men, a trend to increase was evidenced suggesting a better antioxidant profile in people practicing more physical activity. Accordingly, it has been reported that participants with a lower serum Se concentration may be exposed to a greater chronic oxidative stress due to neutrophil reactive oxygen species production [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Trace element contents in toenails are related to regular physical activity in older adults

et al. 2017

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The aim was to assess the trace element contents in toenails of older adults and its association with regular physical activity. Cross-sectional multicentre study in Spain, collecting data from a random sample of 380 participants (54% female) aged 55–80 years (men) and 60–80 years (women) with no previously documented cardiovascular disease. Physical activity performed was measured using the Minnesota Leisure-time Physical Activity Questionnaire. The 25 most inactive and 25 most active individuals for each sex were selected for this study (final sample n = 100). Anthropometric measurements were performed and toenail samples collected for calcium (Ca), chromium (Cr), iron (Fe), cobalt (Co), nickel (Ni), zinc (Zn), selenium (Se) and mercury (Hg) analysis. Significant differences between sexes were reported in Ca concentrations, women having lower concentrations than men. No differences were reported in trace element contents between active and inactive men. Active women showed higher Ca, Cr, Fe, Co, and Zn and lower Hg contents than their inactive peers (all p<0.05). Inactive women showed lower Ca and Co levels (735.0 mg/kg and 4.5 μg/kg, respectively) than inactive men (1170.0 mg/kg and 7.9 μg/kg, respectively). Active women had lower Ca and higher levels of Cr (936.0 mg/kg and 1230.0 μg/kg, respectively) than active men (1070.0 mg/kg and 522.0 μg/kg, respectively). The present data added new information on the element contents in toenails of healthy Spanish older adults. The concentration of trace elements was similar in both sexes except for Ca which were lower in women. The trace element contents in women’s toenails, but not in men, were markedly influenced by physical activity, with higher levels of Ca and Fe and lower Hg among active females.

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“…Opsonization is a humoral immune response involving the complement system that facilitates the capture and uptake of foreign substances by neutrophils and other phagocytes. An increase in SOA causes neutrophil activation and stimulates the secretion of reactive oxygen species (ROS)[ 36 , 37 ], which is associated with physical stress[ 38 - 40 ]. Among ROS, superoxide anions (O 2- ) and hydrogen peroxide (H 2 O 2 ) induce DNA fragmentation in cells, causing inflammation and tissue damage[ 37 ].…”

Section: Assessment Of Physical Stress By Soamentioning

confidence: 99%

Assessment of physical stress during the perioperative period of endoscopic submucosal dissection

Chinda¹,

Shimoyama²

2022

WJG

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The advantage of endoscopic submucosal dissection (ESD) is that it is less invasive than surgery. ESD is one of the best treatments for older patients as surgery in this age group of patients is difficult. However, it is unclear how much lower the physical stress of ESD is compared with that of surgery. Thus, objective methods are required to assess physical stress in patients who have undergone ESD. The current review of ESD aimed to summarize the recent advancements in the assessment of physical stress during the perioperative period, focusing on changes in energy metabolism and serum opsonic activity (SOA). Based on metabolic changes, resting energy expenditure (REE) was measured using an indirect calorimeter. The stress factor calculated from the REE and the basal energy expenditure computed using the Harris-Benedict equation can be used to assess physical stress. SOA was assessed using the chemiluminescence method, wherein the use of chemiluminescent probes ( i.e. , lucigenin and luminol) allowed quantification of reactive oxygen species generated by neutrophils. Using an auto luminescence analyzer, the results were evaluated based on the maximum light emission and area under the emission curve. These quantifiable results revealed the minimal invasiveness of ESD.

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The Relationship Between Serum Selenium Concentration and Neutrophil Function in Peripheral Blood

Cited by 11 publications

References 36 publications

Impact of Selenium Supplementation in Neutropenia and Immunoglobulin Production in Childhood Cancer Patients

Impact of Selenium Supplementation in Neutropenia and Immunoglobulin Production in Childhood Cancer Patients

Trace element contents in toenails are related to regular physical activity in older adults

Assessment of physical stress during the perioperative period of endoscopic submucosal dissection

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