The Relationship Between Subclinical Ketosis and Ruminal Dysfunction in Dairy Cows

Abstract

ketosis is still an important problem which must be solved in dairy herds. early precise diagnosis and proper evaluation of the cause of the disease is essential for good management of ketosis on dairy farms. The aim of our work was to analyse the occurrence of rumen dysfunction in connection with subclinical ketosis in dairy herds and to evaluate the relationships between betahydroxybutyrate (bhb) concentration in blood and metabolic parameters in blood, urine and rumen fluid. We analysed the results of metabolic profile tests performed in dairy cattle herds from 1,338 cows. The concentration of BHB significantly correlated with glucose, NEFA (nonesterified fatty acids), bilirubin, AST (aspartate aminotransferase), GGT (γ-glutamyl transferase), urea, magnesium and calcium in blood serum and with following parameters of rumen fluid -acetate, propionate, butyrate, acetate/propionate and infusoria. Significant but weak correlations were found between BHB and urine parameters (pH, specific gravity, potassium, magnesium, chloride). subclinical ruminal acidosis was found in 23.1% and 16.7% of dairy cows with light (bhb 1.2-2 mmol/L) and more severe subclinical ketosis (BHB >2 mmol/L) and simple ruminal indigestion in 16.7% and 30%, respectively. on the basis of performed analysis we can conclude that rumen dysfunction is an important factor for the development of ketosis. Veterinary practitioners should suggest checking the feeding management in their diagnostic work with the aim to distinguish primary and secondary ketosis. only complex and precise diagnostic work allows applying correct and successful therapy not only for individual animals but also for herd health management.

Prevalence, risk factors and metabolic predictors associated with subclinical ketosis on dairy cattle in Batna, Eastern of Algeria

“…This finding supports previous research, which reported a good positive correlation between acetoacetate and total bilirubin (Kauppinen 1984;Ropstad et al 1989). Our findings regarding relations between BHBA and bilirubin but not between BHBA and ASAT are consistent with results reported by Pechová and Nečasová (2018).…”

Differences in the serum metabolome profile of dairy cows according to the BHB concentration revealed by proton nuclear magnetic resonance spectroscopy (1H-NMR)

“…As a first confirmation, Yanibada et al (2020) found in the plasma of dairy cows that dimethylsulfone and formate are inversely related to methane ruminal production. A second confirmation comes from acetate, a fatty acid produced during ruminal fermentation 30 , which was significantly increased in Group G2. This fatty acid is positively related to methanogenesis 31 and can be used by animals for energetic production when bound to coenzyme A 32 .…”

Healthy Cattle Microbiome and Dysbiosis in Diseased Phenotypes

“…The prognosis predicts intensive feeding of a high carbohydrate diet by cattle, leading to accumulation of short-chain fatty acids, lactic acid, and LPS in the rumen [120]. This results in an extreme drop of rumen pH reaching <5.8 for at least 3 h in a day [121]. There are two forms of ruminal acidosis; clinical (acute) and subclinical ruminal acidosis (SARA) [122].…”