The Relationship between TSH Values and Cardiovascular Risk Factors in Patients with Autoimmune Thyroiditis and Subclinical Hypothyroidism

Некрасова, Т. А.; Стронгин, Л Г; Леденцова, О. В.; Kasakova, L V

doi:10.14341/cet201410216-21

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…Efficient synthesis of thyroid hormones requires adequate iron status, as TPO only exhibits activity on the apical surface of thyroid cells after binding with the prosthetic heme group [11]. Observational studies have also reported a higher prevalence of iron deficiency and lower serum iron concentrations in patients with subclinical hypothyroidism or Hashimoto's thyroiditis compared to healthy controls [43,44]. However, our MR analysis did not reveal a direct causal relationship between iron status biomarkers and thyroid dysfunction (both dominant and subclinical).…”

Section: Replicated Analysescontrasting

confidence: 68%

“…Additionally, a study conducted in India by Das et al [53] revealed that small cell anemia ranked as the second most prevalent type of anemia among individuals with hypothyroidism, following normal cell normal pigmentary anemia. An initial animal study [13] demonstrated that supplementation of T3 in hypothyroid rats restored gastrointestinal iron absorption, while treatment with T4 for 1 year in women with subclinical hypothyroidism and iron deficiency was associated with a reduced incidence of anemia and slightly elevated levels of ferritin, iron, and Hb [44]. Furthermore, a recent study indicated that the utilization of a novel liquid L-T4 preparation can be concomitantly administered with iron salts without compromising absorption [45].…”

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confidence: 99%

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Iron status, thyroid dysfunction and iron deficiency anemia: a two-sample Mendelian randomization study

Huang,

Guo,

et al. 2023

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ObjectiveGiven the clinical association between thyroid dysfunction and iron deficiency anemia (IDA), as well as their shared association with iron status, this study aims to investigate the causal relationship between iron status and thyroid dysfunction, while also examining the risk of IDA in relation to thyroid dysfunction.MethodsA two-sample Mendelian randomization (MR) study was conducted to identify the causal relationship of iron status on thyroid dysfunction, as well as thyroid dysfunction on IDA. Large-scale European population-based GWAS databases were utilized (Genetics of Iron Status consortium, ThyroidOmics consortium, FinnGen consortium, and UK biobank). Inverse variance weighted (IVW) was used as the main analysis. In addition, we used weighted median and MR-Egger to enhance the robustness. Sensitivity analysis was conducted to evaluate the robustness of MR results.ResultsThe IVW estimates did not reveal any significant causal relationship between serum iron status markers and thyroid dysfunction. However, a significant causal relationship was observed between hypothyroidism and IDA (OR = 1.101, 95% CI = 1.048-1.157,p< 0.001). Repeated analyses also demonstrated a similar trend (OR = 1.023, 95% CI = 1.011-1.035,p< 0.001). Sensitivity analysis supported that the MR estimates were robust.ConclusionIn our MR study, an upregulation of the hypothyroidism-associated gene was found to be significantly associated with an elevated risk of IDA in the European population. These findings may offer novel therapeutic insights for clinicians managing patients with hypothyroidism, IDA, or their comorbidities.

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Section: Replicated Analysescontrasting

confidence: 68%

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confidence: 99%

Iron status, thyroid dysfunction and iron deficiency anemia: a two-sample Mendelian randomization study

Huang,

Guo,

et al. 2023

Preprint

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“…Гипотиреоз приводит к дистрофическим изменениям сердечной мышцы вследствие недостаточности коронарного кровотока и нарушений обмена веществ в миокарде. Клинически это проявляется кардиалгиями и дилатацией полостей сердца, наблюдается диастолическая дисфункция, которую диагностируют уже при СГ [8,9]. Повышение артериального давления (АД) при гипотиреозе встречается чаще, чем в общей популяции, а также увеличивается риск развития артериальной гипертензии (АГ) у пациентов с ИБС [10].…”

Section: сердечно-сосудистая системаunclassified

Hypothyroidism: find and neutralize

et al. 2021

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Hypothyroidism is one of the most common diseases of the endocrine system. It is more often recorded in older women. This disease is characterized by nonspecific symptoms and a blurred clinical picture. Patients often have many symptoms from various organs and systems. Because of this, hypothyroidism often remains unrecognized, and patients are not prescribed the necessary therapy on time. Doctors of various specialties should pay attention to the symptoms that may manifest as hypothyroidism. This is especially true for elderly patients. As a screening, the definition of thyroid-stimulating hormone (TSH) is used. First of all, attention should be paid to the pathology of the cardiovascular system, the presence of arterial hypertension, often diastolic and poorly controlled, a decrease in stroke volume and heart rate. Also, in hypothyroidism, lipid metabolism disorders, an earlier onset of atherosclerosis, a connection with metabolic syndrome and type 2 diabetes mellitus were noted. Therefore, it is recommended to diagnose hypothyroidism in patients with these diseases. Screening should also be done in the presence of neurological disorders, depressive and anxiety disorders, gastrointestinal diseases, and hematological disorders (anemias). The determination of TSH is included in the examination plan for infertility, and may also be necessary for other disorders of the reproductive system: menstrual irregularities in women and androgen deficiency in men. Treatment of overt hypothyroidism consists in the appointment of replacement therapy with levothyroxine. If subclinical hypothyroidism is detected, the question of treatment is decided individually and depends on the level of TSH, the patient’s age, and the clinical manifestations of the disease.

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Elimination of iodine deficiency is a concern for the health of the nation. An excursion into the history, scientific aspects and the current state of the legal regulation of the problem in Russia

Трошина

2022

Probl Endokrinol (Mosk)

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The article presents current data on the prevalence of thyroid diseases associated with iodine deficiency in Russia, focuses on the features of the comorbidity of iodine deficiency and autoimmune thyroid pathologies, methods for assessing the iodine supply of the population. Information about the study and prevention of iodine deficiency diseases (IDD) in the USSR and the Russian Federation is given. The history of legislative initiatives aimed at eliminating dietary iodine deficiency and preventing IDD is illustrated in detail. The ways of solving the problem of iodine deficiency at the present stage, both at the federal and regional levels, are proposed.

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The Relationship between TSH Values and Cardiovascular Risk Factors in Patients with Autoimmune Thyroiditis and Subclinical Hypothyroidism

Cited by 7 publications

References 7 publications

Iron status, thyroid dysfunction and iron deficiency anemia: a two-sample Mendelian randomization study

Iron status, thyroid dysfunction and iron deficiency anemia: a two-sample Mendelian randomization study

Hypothyroidism: find and neutralize

Elimination of iodine deficiency is a concern for the health of the nation. An excursion into the history, scientific aspects and the current state of the legal regulation of the problem in Russia

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