The Relationship of Vitamin D Status to Cardiovascular Risk Factors and Amputation Risk in Veterans With Peripheral Arterial Disease

Gaddipati, Vamsi C.; Bailey, Beth A.; Kuriacose, Reena; Copeland, Rebecca; Manning, Todd; Peiris, Alan N.

doi:10.1016/j.jamda.2010.02.006

Cited by 40 publications

(20 citation statements)

References 31 publications

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“…It found that individuals who were vitamin D deficient had higher amputation rates when compared to individuals who were non-deficient. 35 Along with vitamin D deficiency, low hemoglobin levels have been linked with poorer outcomes for patients with IHD as well as heart failure. [36][37][38] In IHD patients, anemia is an independent predictor of both short and long term mortality.…”

Section: Discussionmentioning

confidence: 99%

Non-traumatic lower limb amputation in patients with end-stage renal failure on dialysis: an Australian perspective

et al. 2016

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Background: End-stage renal failure (ESRF) and dialysis have been identified as a risk factor for lower limb amputations (LLAs). High rate of ESRF amongst the Australian population has been reported, however till date no study has been published identifying magnitude and risk factors of LLA in subjects on renal dialysis. Objective: The study aims to document trends in the prevalence and identify risk factors of nontraumatic LLA in Australian patients on dialysis. Methods: A retrospective review of all patients (218) ] p¼ 0.01). 75% of the amputees had aboriginal heritage. We also identified higher HbA1c and CRP levels as well as low serum albumin, hemoglobin and vitamin D levels to have a strong association with LLAs (p < 0.05). Conclusion: There is high prevalence of LLAs amongst Australian indigenous patients with diabetes on dialysis in North Queensland. Other strongly associated risk factors include history of foot ulceration, foot deformity and peripheral neuropathy as well as high HbA1c levels and low serum albumin levels.

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Section: Discussionmentioning

confidence: 99%

Non-traumatic lower limb amputation in patients with end-stage renal failure on dialysis: an Australian perspective

et al. 2016

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“…The serum 25-hydroxyvitamin D (25(OH)D) level is the most widely used measurement to assess overall vitamin D status [5]. Serum 25(OH)D levels are inversely associated with several CVDs, including myocardial infarction (MI) [6,7], coronary artery disease (CAD), heart failure, atrial fibrillation, ventricular tachycardia [8], peripheral vascular disease (PVD) [8,9,10,11], stroke [8,12], incident coronary artery calcium (CAC) [13,14,15,16], cardiac valve and vascular calcification [17] and all CVDs [18]. …”

Section: Introductionmentioning

confidence: 99%

Does Sufficient Evidence Exist to Support a Causal Association between Vitamin D Status and Cardiovascular Disease Risk? An Assessment Using Hill’s Criteria for Causality

2014

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Serum 25-hydroxyvitamin D (25(OH)D) levels have been found to be inversely associated with both prevalent and incident cardiovascular disease (CVD) risk factors; dyslipidemia, hypertension and diabetes mellitus. This review looks for evidence of a causal association between low 25(OH)D levels and increased CVD risk. We evaluated journal articles in light of Hill’s criteria for causality in a biological system. The results of our assessment are as follows. Strength of association: many randomized controlled trials (RCTs), prospective and cross-sectional studies found statistically significant inverse associations between 25(OH)D levels and CVD risk factors. Consistency of observed association: most studies found statistically significant inverse associations between 25(OH)D levels and CVD risk factors in various populations, locations and circumstances. Temporality of association: many RCTs and prospective studies found statistically significant inverse associations between 25(OH)D levels and CVD risk factors. Biological gradient (dose-response curve): most studies assessing 25(OH)D levels and CVD risk found an inverse association exhibiting a linear biological gradient. Plausibility of biology: several plausible cellular-level causative mechanisms and biological pathways may lead from a low 25(OH)D level to increased risk for CVD with mediators, such as dyslipidemia, hypertension and diabetes mellitus. Experimental evidence: some well-designed RCTs found increased CVD risk factors with decreasing 25(OH)D levels. Analogy: the association between serum 25(OH)D levels and CVD risk is analogous to that between 25(OH)D levels and the risk of overall cancer, periodontal disease, multiple sclerosis and breast cancer. Conclusion: all relevant Hill criteria for a causal association in a biological system are satisfied to indicate a low 25(OH)D level as a CVD risk factor.

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“…Low vitamin D concentrations are associated with a higher likelihood of the occurrence of diabetic complications, such as cardiovascular disease [3], renal impairment [4] and peripheral arterial disease [5]. In addition, diabetic patients are a high risk category for developing vitamin D deficiency, which may potentially lead to diabetic complications.…”

Section: Introductionmentioning

confidence: 99%

Serum 25(OH) D in Diabetes Mellitus Type 2: Relation to Glycaemic Control

Al-Timimi

Ali

2013

JCDR

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Introduction: There is increasing evidence on association between vitamin D insufficiency and diabetes, but the impact of vitamin D status on glycaemic status and vice versa, has not been well reported. Our aim was to investigate the level of 25-hydroxyvitamin D(25(OH)D) and the prevalence of vitamin D abnormalities in patients with diabetes mellitus (DM) type2 and in those without diabetes; and to ascertain the impact of 25(OH)D levels on glycaemic control and vice versa.

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The Relationship of Vitamin D Status to Cardiovascular Risk Factors and Amputation Risk in Veterans With Peripheral Arterial Disease

Cited by 40 publications

References 31 publications

Non-traumatic lower limb amputation in patients with end-stage renal failure on dialysis: an Australian perspective

Non-traumatic lower limb amputation in patients with end-stage renal failure on dialysis: an Australian perspective

Does Sufficient Evidence Exist to Support a Causal Association between Vitamin D Status and Cardiovascular Disease Risk? An Assessment Using Hill’s Criteria for Causality

Serum 25(OH) D in Diabetes Mellitus Type 2: Relation to Glycaemic Control

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