The relative roles of hepatitis B and C viruses in the etiology of hepatocellular carcinoma in southern African blacks

Mc, Kew; Yu, Ming; Ma, Ketao; Coppin, A; Sarkin, A; Hodkinson, John

doi:10.1016/s0016-5085(97)70233-6

Cited by 141 publications

(91 citation statements)

References 3 publications

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“…This link was expected and is unquestionable, as has been reported previously [40] . Coinfection with HBV was also found as an additional etiological factor for HCC in the current study, which supports other published studies [42,43] . In two HCV-RNA-positive patients, HBV DNA was detected even in the absence of serological markers for HBV in serum.…”

Section: Discussionsupporting

confidence: 93%

Hepatitis C virus genotype 3a infection and hepatocellular carcinoma: Pakistan experience

Idrees¹,

Rafique²,

Rehman³

et al. 2009

WJG

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AIM:To assess the association between chronic hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) in Pakistan, and the genotype distribution among these HCC patients. METHODS:One hundred and sixty-one subjects with HCC were included in this study. Liver biopsy was performed on 145 of the patients; sixteen were excluded because they failed to fulfill the inclusion criteria. Qualitative polymerase chain reaction (PCR) was performed for hepatitis B virus and HCV. Samples positive for HCV RNA were genotyped using genotypespecific PCR and confirmed by HCV 5' noncoding region sequencing analysis. RESULTS:Chronic HCV infection was identified a major risk factor (63.44% of tested HCC patients) for the development of HCC. The time from HCV infection to appearance of cancer was 10-50 years. In the HCC patient population, broader distributions of genotypes were present with genotype 3a as the predominant genotype. Using the type-specific genotyping method, we found HCV genotype 3a in 40.96%, 3b in 15.66%, 1a in 9.63%, and 1b in 2.40% of HCC tissue samples. About 28% of cases were found with mixed genotypes. Two cases were unable to be genotyped because of low viral load. Sixty-six percent of treated patients with cirrhosis had an end of treatment response, but unfortunately they relapsed quickly when the treatment was discontinued, and HCC developed during a median 3.8 years. CONCLUSION:There was a strong association between chronic HCV infection and HCC in Pakistan, and between HCV genotype 3a and HCC.

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Section: Discussionsupporting

confidence: 93%

Hepatitis C virus genotype 3a infection and hepatocellular carcinoma: Pakistan experience

Idrees¹,

Rafique²,

Rehman³

et al. 2009

WJG

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“…1 Chronic hepatitis B (HBV) and C virus (HCV) infections 2 and repeated dietary exposure to the mycotoxin, aflatoxin B 1 , 3 are major risk factors for the tumor in this population, and membranous obstruction of the inferior vena cava is a minor causal association. 4 Although individuals suffering from hereditary hemochromatosis are at greatly increased risk for HCC, 5 dietary iron overload has not hitherto been considered to be an etiologic association of this tumor in Black Africans.…”

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confidence: 99%

Dietary iron overload as a risk factor for hepatocellular carcinoma in black africans

et al. 1998

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Although the iron-loading disease, hereditary hemochromatosis, has a strong causal association with hepatocellular carcinoma (HCC), the carcinogenic potential of dietary iron overload in Black Africans is not known. We investigated this potential by evaluating iron status, alcohol consumption, markers for hepatitis B (HBV) and C virus (HCV) infections, and exposure to dietary aflatoxin B 1 in 24 rural patients with this tumor, 48 race-, sex-, and age-matched hospital-based controls, and 75 related or unrelated close family members of the cancer patients. Iron overload was defined as a raised serum ferritin concentration in combination with a transferrin saturation H60%, and was confirmed histologically when possible. Among 24 patients and 48 hospital controls, the risk of developing HCC in the iron-loaded subjects was 10.6 (95% confidence limits of 1.

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“…[20][21][22] Although the number of patients studied was small, our findings support other reports of the high risk for hepatocellular carcinoma among patients with HBV and HCV coinfection compared with those with HBV or HCV infection alone. [5][6][7] We have shown that among liver transplant recipients with HBV and HCV coinfection, HDV infection is associated with the suppression of HCV replication after OLT. Further study of this intriguing observation may help understand the mechanisms of viral-viral interactions.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 Although HBV and HCV are independent risk factors for the development of hepatocellular carcinoma, together they have a synergistic effect that substantially increases their hepatocarcinogenesis. [5][6][7] The reported prevalence of HBV and HCV coinfection among patients undergoing orthotopic liver transplantation (OLT) has ranged from 2.7% to 10.7%. 8,9 After OLT, recurrence of HBV occurs commonly if hepatitis B immunoglobulin (HBIG) is not administered, and recurrence of HCV is universal.…”

Section: Study Of Liver Diseasesmentioning

confidence: 99%

Clinical and virologic outcomes of hepatitis B and C viral coinfection after liver transplantation: Effect of viral hepatitis D

et al. 2000

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Hepatitis B (HBV) and C viral (HCV) dual-infectionassociated liver disease is an uncommon indication for liver transplantation. The clinical and virologic outcomes in such patients have not been well studied. We retrospectively studied 13 patients with hepatitis B surface antigen (HBsAg) and antibody to HCV positivity who underwent orthotopic liver transplantation (OLT) and survived at least 30 days post-OLT. Antibody to hepatitis delta virus (HDV) was negative in 8 patients (group I) and positive in 5 patients (group II). Eleven of the 13 patients received standard hepatitis B immune prophylaxis, and they all remained HBsAg negative. All group I patients were HCV RNA positive after transplantation; in contrast, all group II patients were HCV RNA negative. Serum alanine aminotransferase levels were elevated in 88% (7 of 8) of the patients in group I compared with 20% (1 of 5 patients) in group II. None of the patients had graft loss from chronic rejection or recurrent hepatitis. Three patients had unsuspected hepatocellular carcinoma in the explant. We conclude that among liver transplant recipients with HBV and HCV coinfection, HDV infection is associated with the suppression of HCV replication and mild inflammatory activity after OLT.

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The relative roles of hepatitis B and C viruses in the etiology of hepatocellular carcinoma in southern African blacks

Cited by 141 publications

References 3 publications

Hepatitis C virus genotype 3a infection and hepatocellular carcinoma: Pakistan experience

Hepatitis C virus genotype 3a infection and hepatocellular carcinoma: Pakistan experience

Dietary iron overload as a risk factor for hepatocellular carcinoma in black africans

Clinical and virologic outcomes of hepatitis B and C viral coinfection after liver transplantation: Effect of viral hepatitis D

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