The remineralizing effect of an essential oil fluoride mouthrinse in an intraoral caries test

Zero, Domenick T.; Zhang, J.Z.; Harper, D. Scott; Wu, Mingxin; Kelly, Sue; Waskow, J.; Hoffman, Mallory

doi:10.14219/jada.archive.2004.0157

Cited by 32 publications

(39 citation statements)

References 20 publications

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“…A further advantage of the study design is the incorporation of two lesion types. As seen previously, the B-lesions underwent [28] whereas the A-lesions underwent net remineralisation [24]. Since fluoride exerts its anti-caries effect by both reducing demineralisation and promoting remineralisation, it is advantageous to be able to study both phenomena simultaneously.…”

Section: Discussionmentioning

confidence: 76%

“…The in situ model design employed in this clinical study has previously been used as a surrogate predictor of clinical efficacy for caries [24,31]. The principal advantage of this model is that efficacy information on the early stages of the caries process can be obtained in a relatively short time-scale in well-controlled conditions.…”

Section: Discussionmentioning

confidence: 99%

“…These studies showed significant inhibition of fluoride-induced remineralisation by phytate and by zinc. In the current study, a protocol based on an established longer-term in situ caries model [24] was employed to examine the effects of phytate (at two concentrations, the primary focus of the study) and zinc (the secondary focus) separately and together in a regular fluoride toothpaste on remineralisation and prevention of further demineralisation of enamel.…”

Section: A C C E P T E Dmentioning

confidence: 99%

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Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model

Parkinson¹,

Burnett²,

Creeth³

et al. 2018

Journal of Dentistry

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Objectives: To compare and explore the dose-response of phytate-containing 1150 ppm fluoride toothpastes on model caries lesions and to determine the impact of zinc ions.Methods: This was a single-centre, randomised, blinded (examiner/laboratory analyst), sixtreatment, four-period crossover, in situ study in adults with a removable bilateral maxillary partial denture. Study treatments were toothpastes containing: 0.425% phytate/F; 0.85% phytate/F; 0.85% phytate/Zn/F; F-only; Zn/F and a 0% F placebo. Where present, F was 1150 ppm as NaF; Zn was 0.3% Clinical significance: Toothpastes may contain therapeutic or cosmetic agents that could interfere with fluoride's caries prevention efficacy. The present in situ caries study has demonstrated that phytate, added to provide enhanced extrinsic stain removal/prevention, and zinc, added to inhibit malodour, do not impair fluoride efficacy.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: A C C E P T E Dmentioning

confidence: 99%

See 1 more Smart Citation

Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model

Parkinson¹,

Burnett²,

Creeth³

et al. 2018

Journal of Dentistry

View full text Add to dashboard Cite

show abstract

“…100 µm apart from each other), and four using a Vickers diamond indenter using a 200 g load (approx. 150 µm apart from each other and in close proximity to the Knoop indentations), each with a dwelling time of 11 s. The respective indentation loads and number of indentations per specimen were chosen based on standard operating procedures and reflect those typically employed in the main author's laboratories [22,28]. Knoop and Vickers hardness numbers were derived from the respective indentation lengths (Knoop -length of the long diagonal, Vickers -mean of both diagonals) and recorded.…”

Section: Lesion Surface Microhardnessmentioning

confidence: 99%

Fluoride dose-response of human and bovine enamel artificial caries lesions under pH-cycling conditions

Lippert

Juthani

2015

Clin Oral Invest

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Objectives This laboratory study aimed to: a) compare the fluoride dose-response of different caries lesions created in human and bovine enamel (HE/BE) under pH-cycling conditions, and b) investigate the suitability of Knoop and Vickers surface microhardness (K-SMH/V-SMH) in comparison to transverse microradiography (TMR) to investigate lesion de-and remineralization.Materials and Methods Caries lesions were formed using three different protocols (Carbopol, hydroxyethylcellulose-HEC, methylcellulose-MeC) and assigned to 24 groups using V-SMH, based on a 2 (enamel types)×3 (lesion types)×4 (fluoride concentrations used during pH-cycling-simulating 0/250/1100/2800 ppm F as sodium fluoride dentifrices) factorial design. Changes in mineral content and structural integrity of lesions were determined before and after pH-cycling. Data were analyzed using three-way ANOVA.Results BE was more prone to demineralization than HE. Both enamel types showed similar responses to fluoride with BE showing more remineralization (as change in integrated mineral loss and lesion depth reduction), although differences between tissues were already present at lesion baseline. Carbopol and MeC lesions responded well to fluoride, whereas HEC lesions were almost inert. K-and V-SMH correlated well with each other and with the integrated mineral loss data, although better correlations were found for HE than for BE, and for MeC than for Carbopol lesions. Hardness data for HEC lesions correlated only with surface zone mineral density data.Conclusion BE is a suitable surrogate for HE under pH-cycling conditions. Clinical Relevance The in vitro modelling of dental caries is complex and requires knowledge of lesion behavior, analytical techniques and employed hard tissues.

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“…The present study investigated the interplay between fluoride dose and concentration in milk utilizing an established in situ caries model, 18 with the key features being the use of gauzecovered specimens mounted flush with the denture surface to facilitate plaque growth and retention, early, surface-softened caries lesions that mimic the onset of caries, and the simulation of a caries-prone stagnation area. Furthermore, no diet restrictions were imposed on the study subjects, and a mandibular partial denture, containing the specimens, was worn by the subjects 24 h a day including during meals.…”

Section: Discussionmentioning

confidence: 99%

An in situ caries study on the interplay between fluoride dose and concentration in milk

Lippert

Martínez-Mier

Zero

2014

Journal of Dentistry

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Objectives: This randomized, cross-over in situ study investigated the impact of sodium fluoride dose and concentration in milk on caries lesion rehardening, fluoridation and acid resistance.Methods: Twenty-eight subjects wore two gauze-covered enamel specimens with preformed lesions placed buccally on their mandibular partial dentures for three weeks. Participants used fluoride-free dentifrice throughout the study and consumed once daily one of the five study treatments: no fluoride in 200ml milk (0F-200), 1.5 or 3mg fluoride in either 100 (1.5F-100; 3F-100) or 200ml milk (1. 5F-200; 3F-200). After three weeks, specimens were retrieved. Knoop hardness was used to determine rehardening and resistance to a secondary acid challenge.Enamel fluoride uptake (EFU) was determined using a microbiopsy technique. were also more discerning than rehardening data. Conclusions:The present study has provided further evidence for the anti-caries benefits of fluoridated milk. Both fluoride dose and concentration appear to impact the cariostatic properties of fluoride in milk. IntroductionThe delivery of cariostatic amounts of fluoride through milk is not novel by any means as the first caries studies in children were conducted in the 1960s. Milk fluoridation has been recommended where fluoride concentration in the drinking water is suboptimal, for target groups with high caries prevalence and poor compliance for oral hygiene, in areas without or suboptimal water fluoridation and where school-or kindergarten-based programs to provide milk to children are already in place. 3,4Recent research has focused on determining if fluoride in milk follows a dose-response pattern and if an optimum fluoride concentration exists. However, results of laboratory [5][6][7] and in situ studies 8,9 into the anti-caries effects of different milk fluoride concentrations have been somewhat equivocal -benefits of fluoridated vs. non-fluoridated milk have been reported unanimously in vitro and in situ; although a clear fluoride dose-response relationship has yet to be established in situ. Likewise, there appears to be some disagreement with regards to an optimum fluoride concentration in milk as results obtained using a range of laboratory models led authors to different conclusions. 5-7Furthermore, the cariostatic properties of fluoride do not only depend on dose but also on concentration. 10While drawing parallels to conventional fluoride delivery vehicles, such as dentifrices and rinses, is not straightforward, especially considering their much higher fluoride concentrations in comparison to milk, a study on rinses demonstrated that, for a given fluoride dose, the main driving force for efficacy was fluoride concentration; i.e. rinsing with a smaller volume but higher fluoride concentration was more beneficial than rinsing with a larger volume but lower fluoride concentration.Therefore, the aims of the present in situ study were three-fold: a) the primary objective was to determine if a higher dose of fluoride in milk would provide a greater...

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The remineralizing effect of an essential oil fluoride mouthrinse in an intraoral caries test

Cited by 32 publications

References 20 publications

Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model

Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model

Fluoride dose-response of human and bovine enamel artificial caries lesions under pH-cycling conditions

An in situ caries study on the interplay between fluoride dose and concentration in milk

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