1968
DOI: 10.1083/jcb.39.1.169
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The Renewal of Protein in Retinal Rods and Cones

Abstract: The renewal of protein in retinal rods and cones has been analyzed by quantitative electron microscope radioautography in adult frogs injected with a mixture of radioactive amino acids. Protein synthesis occurs predominantly in the ergastoplasm, localized in the myoid region of the photoreceptor cells. Much of the newly formed protein next flows through the Golgi complex. In rods, a large proportion of the protein then moves past the mitochondria of the ellipsoid segment, passes through the connecting cilium i… Show more

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Cited by 371 publications
(146 citation statements)
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“…Rods and cones renew their outer segments continually [6,7]. Newly formed disks at the base of the outer segment progressively displace previously synthesized disks toward the apical end.…”
Section: Development Of Mouse Photoreceptorsmentioning
confidence: 99%
“…Rods and cones renew their outer segments continually [6,7]. Newly formed disks at the base of the outer segment progressively displace previously synthesized disks toward the apical end.…”
Section: Development Of Mouse Photoreceptorsmentioning
confidence: 99%
“…The process of photoreceptor disc shedding and renewal and the role for RPE in phagocytizing the shed discs have been known since the work of Young and colleagues (Young, 1967; Young and Bok, 1969;Young and Droz, 1968). Although some components involved in the process have been identified, the phagocytosis of outer segment discs by RPE cells remains poorly understood.…”
Section: Discussionmentioning
confidence: 99%
“…In fact, the length of the outer segments remains constant as a consequence of a well-regulated biogenesis of photoreceptor membranes in the inner segments coupled to phagocytosis of the shed tips. During photoreceptor outer segment renewal, proteins turn over and are continually replaced ( 37 ). In contrast, docosahexaenoic acid (DHA) and vitamin A from the opsin chromophore are recycled back from the RPE to inner segments through the interphotoreceptor matrix.…”
Section: The Maintenance Of Photoreceptor Cell Integritymentioning
confidence: 99%
“…RPE cells are the most active phagocytes of the body. In mammals, the circadian shedding and phagocytosis has been calculated to be complete after 10 days for one photoreceptor outer segment ( 36,37 ). In rhesus monkeys, every RPE cell interacts with 20-45 photoreceptor tips ( 38 ), and the human macula support the RPE/photoreceptor interaction in a ratio of 1 to 23 ( 39 ).…”
Section: The Maintenance Of Photoreceptor Cell Integritymentioning
confidence: 99%