The Research Progress of Targeted Drug Delivery Systems

Abstract

Abstract. Targeted drug delivery system (DDS) means to selectively transport drugs to targeted tissues, organs, and cells through a variety of drugs carrier. It is usually designed to improve the pharmacological and therapeutic properties of conventional drugs and to overcome problems such as limited solubility, drug aggregation, poor bio distribution and lack of selectivity, controlling drug release carrier and to reduce normal tissue damage. With the characteristics of nontoxic and biodegradable, it can increase the retention of drug in lesion site and the permeability, improve the concentration of the drug in lesion site.at present, there are some kinds of DDS using at test phase, such as slow controlled release drug delivery system, targeted drug delivery systems, transdermal drug delivery system, adhesion dosing system and so on. This paper makes a review for DDS.

Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery

“…Chitosan and its derivatives have been exploited to fabricate targeted drug delivery systems to achieve the desired effect of drug at lower concentrations [65] by attaching various ligands, which include peptides, vitamins, hormones, carbohydrates, and proteins, as shown in Table 2. Receptor-mediated endocytosis is the primary route of uptake for targeted systems functionalized with ligands [66][67][68][69].…”

Herbonanoceuticals: A Novel Beginning in Drug Discovery and Therapeutics

“…Controlled drug delivery A targeted drug delivery system is intended to specifically transport medications to target tissues, organs, and cells through use of an assortment of drug transporters Controlled delivery of medications improved the drug delivery approaches Tiwari et al (2012) It is generally intended to enhance the pharmacological and remedial properties of traditional medications and to overcome problems such as limited solubility, drug aggregation, poor biodispersion, and absence of selectivity, controlling the drug delivery carrier and lessening associated tissue injury Controlled delivery controls the site and the rate of medication release Tiwari et al (2012) It can be intended to limit drug degradation, increment bioavailability, permit targeting of particular cells, and diminish the total amount of medication required; it can also control the delivery of medication to minimize lethality and unsafe reactions Conventional dosing regimens cause fluctuations in plasma drug concentrations; these changes depend upon what happens to the medication inside the body, such as its retention, dispersion, digestion, and discharge; controlled release eliminates such fluctuations in plasma drug concentrations Tiwari (2016); Allen and Cullis (2004) Targeted medications initially are mostly utilized as a part of disease treatment; optimization of the adequacy of a medication is of prime significance in the choice of a delivery system A controlled drug delivery system enhances patient compliance, particularly in long-term treatment for persistent infections Zhan et al (2017); Tiwari (2016) Targeted drug delivery is a strategy for administering medicine to a patient in a way that restricts the concentration of the medication to particular tissues These systems have advantages over conventional drug delivery systems, including limiting the time of medication release, safeguarding fragile medications, and increasing patient comfort and compliance Manish and Vimukta (2011); Zadbuke et al (2013) This improves the efficacy of the medication while reducing its side effects This reduces drug doses and dosing frequencies Tiwari (2016) Drug targeting is the delivery of drugs to receptors or organs or any other specific part of the body to which one wishes to deliver the drug exclusively Controlled drug delivery occurs when a polymer is combined with a drug or active agent such that the release from the bulk material is predesigned Manish and Vimukta (2011); Anupama et al (2016) Targeted delivery of the drugs enhance the efficacy of the drug to the target site and prevents adverse effects, and increases the bioavailability of the medication.…”

Dealing with Skin and Blood-Brain Barriers: The Unconventional Challenges of Mesoporous Silica Nanoparticles

“…To fulfill this need, the delivery of drugs is often committed to smart NPs that are able to recognize the target organs, tissues, and cells, overcoming problems such as limited solubility, molecular aggregation, poor biodistribution, and lack of selectivity [30].…”