The resistance to blood flow in the gastrocnemius of the dog during sustained and rhythmical isometric and isotonic contractions

Hirche, Hj.; Raff, W. K.; Grúň, Daniel

doi:10.1007/bf00587195

Cited by 23 publications

(9 citation statements)

References 6 publications

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“…With stronger contractions, however, the blood pres sure, heart rate, and cardiac output invariably continue to rise until muscular fatigue prohibits continued contraction. In keeping with earlier suppositions, it is now clear that stronger contractions can cause mechanical interference to blood flow to the muscle (8,19,20), and the resultant ischemia presumably contributes to the rapid development of fatigue. In general, the rate at which hemodynamic factors change during exertion and the final extent of their change are directly related to the strength of muscle contraction and inversely related to the time required to produce fatigue.…”

Section: Cardiov Ascular Effects Of Static Exercisementioning

confidence: 80%

Static (Isometric) Exercise and the Heart: Physiological and Clinical Considerations

Mitchell¹,

Wildenthal²

1974

Annu. Rev. Med.

164

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Section: Cardiov Ascular Effects Of Static Exercisementioning

confidence: 80%

Static (Isometric) Exercise and the Heart: Physiological and Clinical Considerations

Mitchell¹,

Wildenthal²

1974

Annu. Rev. Med.

164

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“…Indeed, the intramuscular pressure (IMP) is known to increase profoundly even during mild contractions, causing the vasculature to intermittently collapse and blood flow and shear stress to oscillate (Barcroft and Millen 1939; Hirche et al 1970; Radegran and Saltin 1998). Studies that used inflatable cuffs to mimic the action of contraction-induced oscillations in IMP advanced the notion that this mechanism can evoke vasodilation (Kirby et al 2007) and reduce regional arterial stiffness (Heffernan et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Impact of chronic intermittent external compressions on forearm blood flow capacity in humans

et al. 2010

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During dynamic exercise, the vasculature embedded within skeletal muscle intermittently collapses due to increased intramuscular pressure (IMP). The aim of this study was to ascertain whether oscillations in IMP during muscle contractions independently contribute to exercise training-induced increases in blood flow capacity (BFC). Based on IMP measurements during handgrip exercise, we attempted to mimic the action of repeated vascular compressions by using external inflatable cuffs. Thus, 24 healthy young male subjects underwent a 4-week program (5 days/week, 1 h/day) of application of external compressions of the non-dominant forearm, while the dominant limb served as an internal control. To evaluate the impact of compression pressures of different magnitudes, subjects were randomly assigned to one of three groups: 50, 100 and 150 mmHg of external compression. Prior to the intervention and after 2 and 4 weeks of treatment, we measured peak forearm blood flow (PBF) (Doppler ultrasound) and calculated peak vascular conductance (PVC) following 10 min of forearm ischemia. In the 50 and 100 mmHg groups, application of intermittent compressions did not alter PBF in either control or intervention forearms. In the 150 mmHg group, there was a trend (P = 0.04) for greater increases in PBF from baseline after 4 weeks in the intervention forearm compared to the control forearm (delta PBF: 4.2 ± 2.5 vs. −2.1 ± 2.0 (ml(100 ml)−1 min−1), in the intervention and control forearms, respectively), but the changes in PVC were not significant (P = 0.1). These findings suggest that repeated oscillations in IMP contribute minimally to exercise-induced increase in forearm BFC in healthy young humans.

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“…This interaction plays an important role in, for example, compartment syndrome, where blood perfusion decreases when intramuscular pressure increases (Reneman et al, 1980, Shrier andMagder, 1995). Reduced blood flow in muscle during tetanic contraction is also a result of this interaction (Barcroft and Miller, 1939, Hirche et al, 1970, Livingston and Resar, 1993. The exact mechanism of this interaction is not quite clear.…”

Section: Introductionmentioning

confidence: 99%

Mechanical blood-tissue interaction in contracting muscles

Vankan

Huyghe

Donkelaar

et al. 1998

Journal of Biomechanics

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A finite element (FE) model of blood perfused biological tissue has been developed. Blood perfusion is described by fluid flow through a series of 5 intercommunicating vascular compartments that are embedded in the tissue. Each compartment is characterized by a blood flow permeability tensor, blood volume fraction and vessel compliance. Local non-linear relationships between intra-extra vascular pressure difference and blood volume fraction, and between blood volume fraction and the permeability tensor, are included in the FE model. To test the implementation of these non-linear relations, FE results of blood perfusion in a piece of tissue that is subject to increased intramuscular pressure, are compared to results that are calculated with a lumped parameter (LP) model of blood perfusion. FE simulation of blood flow through a contracting rat calf muscle is performed. The FE model used in this simulation contains a transversely isotropic, non-linearly elastic description of deforming muscle tissue, in which local contraction stress is prescribed as a function of time. FE results of muscle tension, total arterial inflow and total venous outflow of the muscle during contraction, correspond to experimental results of an isometrically and tetanically contracting rat calf muscle.

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The resistance to blood flow in the gastrocnemius of the dog during sustained and rhythmical isometric and isotonic contractions

Cited by 23 publications

References 6 publications

Static (Isometric) Exercise and the Heart: Physiological and Clinical Considerations

Static (Isometric) Exercise and the Heart: Physiological and Clinical Considerations

Impact of chronic intermittent external compressions on forearm blood flow capacity in humans

Mechanical blood-tissue interaction in contracting muscles

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