The response of elderly community residents to request for brain donation: An interim report

Beardsall, Lynn; Barkley, Claire; O'Sullivan, Angela

doi:10.1002/gps.930070309

Cited by 17 publications

(15 citation statements)

References 9 publications

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“…In the present study, 92.8 % of the patients interviewed affirmed that they would consent to donate their brains for scientific research. This proportion is close to the proportions found in other studies that also investigated patients' interests in participating in this kind of study (Garrick et al 2009;Kuhta et al 2011;Beardsall et al 1992).…”

Section: Discussionsupporting

confidence: 84%

“…Close contact with an ill person, the desire to help people who suffer with the disease and understanding the necessity of scientific research for finding a cure positively influence their decision (Schmitt et al 2001;Garrick et al 2009;Beardsall et al 1992). In contrast, relatives consider it easier to decide about their own organs than about those of another family member (Azizi et al 2006;Garrick et al 2009), which may explain the difference between the consent rates within Group 2.…”

Section: Discussionmentioning

confidence: 90%

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Assessing families’ and patients’ attitudes toward brain donation for research purposes in a Brazilian population sample

et al. 2014

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The neuropathological examination of postmortem human brain tissue is an essential resource for the definitive diagnosis and research on neurodegenerative diseases. Due to the growing need of donated brains to supply the Brain Banks, the understanding of the factors associated with the consent for the donation in our context is an important aspect of the process of brain donation. The verbal answers and the donation consent rate were evaluated in three groups: 30 relatives of patients who underwent verification of the cause of death, 14 patients assisted at a neurology ambulatory outpatient clinic, and 18 patients' relatives. The donation consent rates were of 46.6, 92.8 and 88.8 %, respectively. The main reasons for refusal were the disagreement with the autopsy, philosophical and religious issues, objections from other family members, and the consideration of the wishes of the deceased. The consent was specially motivated by the interest in the advances of scientific knowledge, altruistic reasons and the personal experiences with the disease. Factors as the emotional fragility at the moment of death, the beliefs, family matters, and the lack of knowledge are key elements in the donation process. Future goals include the establishment of a brain donor program with the support of academic institutions, hospitals, scientists, community, patient's associations and autopsy assistants. Approaching patients and relatives in specialized ambulatories clinic during assistance is probably the most efficient mean of obtaining brains for research.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 90%

Assessing families’ and patients’ attitudes toward brain donation for research purposes in a Brazilian population sample

et al. 2014

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“…Samples were also available through the post-mortem study of brain tissue programme which was established at follow-up. This proce dure is described in detail elsewhere [29]. Briefly, assessed individu als were invited by liaison nurses to consider becoming brain tissue donors.…”

Section: The Parent Studymentioning

confidence: 99%

Apolipoprotein E Genotype in the Prediction of Cognitive Decline and Dementia in a Prospectively Studied Elderly Population

Brayne

Harrington²,

Wischik³

et al. 1996

Dement Geriatr Cogn Disord

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An increased apolipoprotein E (ApoE) type Ε4 allele frequency is associated with both sporadic and familial late-onset Alzheimer''s disease (AD). The age of onset of disease in patients homozygous for the Ε4 allele appears to be decreased by approximately 15 years compared with E2/3 individuals. In order to assess the influence of this allele on both dementia and cognitive decline in the elderly we have determined the ApoE genotype of 150 individuals over the age of 75 years who have taken part in a longitudinal study. Homozygosity for the Ε4 allele was rare. Of the 2 homozygotes, 1 was severely demented but the other did not receive a clinical diagnosis of dementia. The latter individual did demonstrate marked cognitive decline over a 28-month period. There was a consistent association between the presence of an Ε4 allele and both the clinical diagnosis of dementia and cognitive decline. These findings confirm a genetic heterogeneity in late-onset sporadic AD and prompt caution in the use of ApoE genotype to predict an elderly individual''s susceptibility to either dementia or cognitive decline.

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“…Approaching participants to raise the possibility of donation to the study's brain collection began shortly after the second full survey, known then as the Cambridge Project for Later Life (CPLL), focussing initially on those who had completed CAMDEX assessments. The recruitment methods and high rates of consent from participants, assent from relatives and successful collection have been previously reported after this initial phase [41]. Subsequently participants whose MMSE scores suggested normal to high cognitive function were also recruited to the brain donation programme to ensure the sample would reflect the full population spectrum.…”

Section: The Cohort Sample: Recruitment Assessments and Brain Donationmentioning

confidence: 99%

Neuropathological Correlates of Falling in the CC75C Population-Based Sample of the Older Old

Richardson¹,

Hunter²,

Dening³

et al. 2012

CAR

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Subclinical pathologies sharing a common vascular origin are associated with increased falling amongst people with no dementia, as are microinfarcts in those with dementia. Although further research is needed to address the mechanisms of falls and their neuropathological correlates, the findings from the current study would suggest that if cerebrovascular disease prevention reduces vascular neuropathology changes this may have direct benefits in reducing falls amongst older people with or without dementia.

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The response of elderly community residents to request for brain donation: An interim report

Cited by 17 publications

References 9 publications

Assessing families’ and patients’ attitudes toward brain donation for research purposes in a Brazilian population sample

Assessing families’ and patients’ attitudes toward brain donation for research purposes in a Brazilian population sample

Apolipoprotein E Genotype in the Prediction of Cognitive Decline and Dementia in a Prospectively Studied Elderly Population

Neuropathological Correlates of Falling in the CC75C Population-Based Sample of the Older Old

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