The responses of the catecholamines and ?-endorphin to brief maximal exercise in man

Brooks, S.; Burrin, Jacky M.; Cheetham, Mary E.; Hall, George; Yeo, T. H.; Williams, Clyde

doi:10.1007/bf00640668

Cited by 54 publications

(19 citation statements)

References 15 publications

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“…In the present study the reduced concentration of plasma catecholamines These observations may explain the high negative correlations between blood pH and plasma adrenaline concentrations that have been reported following short-term maximal continuous exercise (Cheetham et al, 19;Brooks et al, 1988;Nevill et al, 1989). Despite the high circulating levels of plasma adrenaline in the placebo condition, the degree of hyperglycaemia in venous blood was not different between experimental conditions.…”

Section: Discussionsupporting

confidence: 55%

Human muscle metabolism during intermittent maximal exercise

Gaitanos

Williams

Boobis

et al. 1993

Journal of Applied Physiology

755

591

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Eight male subjects volunteered to take part in this study. The exercise protocol consisted of ten 6-s maximal sprints with 30 s of recovery between each sprint on a cycle ergometer. Needle biopsy samples were taken from the vastus lateralis muscle before and after the first sprint and 10 s before and immediately after the tenth sprint. The energy required to sustain the high mean power output (MPO) that was generated over the first 6-s sprint (870.0 +/- 159.2 W) was provided by an equal contribution from phosphocreatine (PCr) degradation and anaerobic glycolysis. Indeed, within the first 6-s bout of maximal exercise PCr concentration had fallen by 57% and muscle lactate concentration had increased to 28.6 mmol/kg dry wt, confirming significant glycolytic activity. However, in the tenth sprint there was no change in muscle lactate concentration even though MPO was reduced only to 73% of that generated in the first sprint. This reduced glycogenolysis occurred despite the high plasma epinephrine concentration of 5.1 +/- 1.5 nmol/l after sprint 9. In face of a considerable reduction in the contribution of anaerobic glycogenolysis to ATP production, it was suggested that, during the last sprint, power output was supported by energy that was mainly derived from PCr degradation and an increased aerobic metabolism.

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Section: Discussionsupporting

confidence: 55%

Human muscle metabolism during intermittent maximal exercise

Gaitanos

Williams

Boobis

et al. 1993

Journal of Applied Physiology

755

591

View full text Add to dashboard Cite

show abstract

“…We have confirmed the results obtained in previous studies [9,36], which showed exercise to induce an increase of ~-endorphin, and have found that nifedipine-SR neither stimulates nor inhibits ~-endorphin release. The precise role of ~-endorphin is not clear.…”

Section: Discussionsupporting

confidence: 81%

Administration of slow-release nifedipine does not affect lactate threshold, hormone release during exercise, and quality of life in normal subjects

Handa

Mori

Tanaka

et al. 1992

Cardiovasc Drug Ther

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In a double-blind crossover study of 10 normal healthy subjects, we examined the effects of slow-release nifedipine (nifedipine-SR, 10 mg b.i.d) administration on exercise capacity, hormone levels during exercise, and quality of life (QOL) after a 2-week treatment. Two exercise tests, a progressive exercise test and a constant work-rate exercise test, were performed. Maximal oxygen uptake (VO2max) and blood lactate concentration were measured during the progressive exercise test and the exercise intensity corresponding to half lactate threshold (LT), LT, and 4 mmol/l of lactate concentration was determined. Subjects underwent 20 minutes of constant work-rate exercise at each work load, and blood lactate, plasma epinephrine, plasma norepinephrine, plasma renin activity, plasma aldosterone, atrial natriuretic peptide, plasma beta-endorphin, and met-enkephalin were measured. Taking nifedipine-SR had no effect on the responses of blood pressure, heart rate, VO2max, maximal work load, and LT compared to taking placebo. Blood lactate, plasma catecholamine, plasma renin activity, aldosterone, atrial natriuretic peptide, and beta-endorphin levels increased during exercise, and there was no difference between nifedipine-SR and placebo. Met-enkephalin did not increase with either treatment. In the QOL questionnaires, no differences were noted between the two treatments. These findings suggest nifedipine-SR to be a potentially useful drug in view of the lack of effect on exercise capacity, hormone release, and QOL.

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“…Nevertheless, it is obvious that both exercise duration and exercise intensity are important determinants of the plasma [CA] response in this type of exercise, as they have also been found in endurance exercise (Kjaer 1989 (Brooks et al 1988(Brooks et al , 1990Cheetham et al 1986;Gratas-Delamarche et al 1994;Schwarz and Kindermann 1990). …”

Section: Discussionmentioning

confidence: 98%

“…However, it has been found that the plasma [A] increase in heavy anaerobic exercise may be higher than in aerobic exercise (Kindermann et al 1982: Schwarz andKindermann 1990). Dierent maximal anaerobic activities such as sprinting (Cheetham et al 1986;Brooks et al 1988) and bicycling (Gaitanos et al 1993;Gratas-Delamarche et al 1994) as well as heavy resistance exercise training (Kraemer et al 1987) have indeed been found to elevate plasma [A] markedly.…”

Section: Introductionmentioning

confidence: 94%

Plasma catecholamine responses to four resistance exercise tests in men and women

et al. 1999

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The plasma adrenaline ([A]) and noradrenaline ([NA]) concentration responses of nine men and eight women were investigated in four resistance exercise tests (E80, E60, E40 and E20), in which the subjects had to perform a maximal number of bilateral knee extension-flexion movements at a given cycle pace of 0.5 Hz, but at different load levels (80%, 60%, 40% and 20% of 1 repetition maximum, respectively). The four test sessions were separated by a minimal interval of 3 rest days. The number of repetitions (Repmax), the total work (Wtot) done normalized for the lean body mass and the heart rate (HR) responses were similar in the two groups in each test. In addition, no differences were found between the two groups in [A] and [NA] either before or after the exercise tests. The postexercise [NA], both in the men [10.8 (SD 7.0) nmol x l(-1)] and in the women [11.7 (SD 7.4) nmol x l(-1)], was clearly the highest in E20, where also the Repmax, WtOt, the total amount of integrated electromyograph activity in the agonist muscles and the peak postexercise blood lactate concentration [men 8.3 (SD 1.6) vs women 7.3 (SD 0.9) mmol x l(-1), ns] were significantly higher than in the other tests. Although the postexercise [A] in E20 both in the men [7.1 (SD 6.0) nmol x l(-1)] and in the women [5.2 (SD 2.0) nmol x l(-1)] were higher than in E80 [men 3.1 (SD 4.2), women 2.1 (SD 2.0) nmol x l(-l)] (P < 0.05), they were not significantly different from E60 [men 3.6 (SD 1.9), women 4.0 (SD 3.3) nmol x l(-1)] and E40 [men 3.8 (SD 4.1), women 5.8 (SD 4.0) nmol x l(-1)] in either group. The present study did not indicate any sex differences in performance and in plasma catecholamine responses in different exhausting resistance exercise tests performed with the knee extensor muscles. In both groups the plasma [NA] response was clearly the largest in the longest exercise with the greatest amount of muscle activity and work done, and with the largest blood lactate response. The differences in the plasma [A] responses between the exercises tended to be somewhat smaller.

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The responses of the catecholamines and ?-endorphin to brief maximal exercise in man

Cited by 54 publications

References 15 publications

Human muscle metabolism during intermittent maximal exercise

Human muscle metabolism during intermittent maximal exercise

Administration of slow-release nifedipine does not affect lactate threshold, hormone release during exercise, and quality of life in normal subjects

Plasma catecholamine responses to four resistance exercise tests in men and women

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